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3-T breast magnetic resonance imaging in patients with suspicious microcalcifications on mammography.
Eur Radiol. 2014 Mar; 24(3):603-9.ER

Abstract

OBJECTIVE

To investigate the diagnostic value of 3-Tesla (T) breast MRI in patients presenting with microcalcifications on mammography.

METHODS

Between January 2006 and May 2009, 123 patients with mammographically detected BI-RADS 3–5 microcalcifications underwent 3-T breast MRI before undergoing breast biopsy. All MRIs of the histopathologically confirmed index lesions were reviewed by two breast radiologists. The detection rate of invasive carcinoma and ductal carcinoma in situ (DCIS) was evaluated, as well as the added diagnostic value of MRI over mammography and breast ultrasound.

RESULTS

At pathology, 40/123 (33%) lesions proved malignant; 28 (70%) DCIS and 12 (30%) invasive carcinoma. Both observers detected all invasive malignancies at MRI, as well as 79% (observer 1) and 86% (observer 2) of in situ lesions. MRI in addition to conventional imaging led to a significant increase in area under the receiver operating characteristic (ROC) curve from 0.67 (95% CI 0.56–0.79) to 0.79 (95% CI 0.70–0.88, observer 1) and to 0.80 (95% CI 0.71–0.89, observer 2), respectively.

CONCLUSIONS

3-T breast MRI was shown to add significant value to conventional imaging in patients presenting with suspicious microcalcifications on mammography.

KEY POINTS

• 3-T MRI is increasingly used for breast imaging in clinical practice. • On 3-T breast MRI up to 86% of DCIS lesions are detected. • 3-T MRI increases the diagnostic value in patients with mammographically detected microcalcifications.

Authors

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Pub Type(s)

Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

24078055

Citation

Stehouwer, B L., et al. "3-T Breast Magnetic Resonance Imaging in Patients With Suspicious Microcalcifications On Mammography." European Radiology, vol. 24, no. 3, 2014, pp. 603-9.
Stehouwer BL, Merckel LG, Verkooijen HM, et al. 3-T breast magnetic resonance imaging in patients with suspicious microcalcifications on mammography. Eur Radiol. 2014;24(3):603-9.
Stehouwer, B. L., Merckel, L. G., Verkooijen, H. M., Peters, N. H., Mann, R. M., Duvivier, K. M., Mali, W. P., Peeters, P. H., Veldhuis, W. B., & van den Bosch, M. A. (2014). 3-T breast magnetic resonance imaging in patients with suspicious microcalcifications on mammography. European Radiology, 24(3), 603-9.
Stehouwer BL, et al. 3-T Breast Magnetic Resonance Imaging in Patients With Suspicious Microcalcifications On Mammography. Eur Radiol. 2014;24(3):603-9. PubMed PMID: 24078055.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - 3-T breast magnetic resonance imaging in patients with suspicious microcalcifications on mammography. AU - Stehouwer,B L, AU - Merckel,L G, AU - Verkooijen,H M, AU - Peters,N H G M, AU - Mann,R M, AU - Duvivier,K M, AU - Mali,W P Th M, AU - Peeters,P H M, AU - Veldhuis,W B, AU - van den Bosch,M A A J, PY - 2013/07/02/received PY - 2013/09/06/accepted PY - 2013/08/30/revised PY - 2013/10/1/entrez PY - 2013/10/1/pubmed PY - 2014/9/24/medline SP - 603 EP - 9 JF - European radiology JO - Eur Radiol VL - 24 IS - 3 N2 - OBJECTIVE: To investigate the diagnostic value of 3-Tesla (T) breast MRI in patients presenting with microcalcifications on mammography. METHODS: Between January 2006 and May 2009, 123 patients with mammographically detected BI-RADS 3–5 microcalcifications underwent 3-T breast MRI before undergoing breast biopsy. All MRIs of the histopathologically confirmed index lesions were reviewed by two breast radiologists. The detection rate of invasive carcinoma and ductal carcinoma in situ (DCIS) was evaluated, as well as the added diagnostic value of MRI over mammography and breast ultrasound. RESULTS: At pathology, 40/123 (33%) lesions proved malignant; 28 (70%) DCIS and 12 (30%) invasive carcinoma. Both observers detected all invasive malignancies at MRI, as well as 79% (observer 1) and 86% (observer 2) of in situ lesions. MRI in addition to conventional imaging led to a significant increase in area under the receiver operating characteristic (ROC) curve from 0.67 (95% CI 0.56–0.79) to 0.79 (95% CI 0.70–0.88, observer 1) and to 0.80 (95% CI 0.71–0.89, observer 2), respectively. CONCLUSIONS: 3-T breast MRI was shown to add significant value to conventional imaging in patients presenting with suspicious microcalcifications on mammography. KEY POINTS: • 3-T MRI is increasingly used for breast imaging in clinical practice. • On 3-T breast MRI up to 86% of DCIS lesions are detected. • 3-T MRI increases the diagnostic value in patients with mammographically detected microcalcifications. SN - 1432-1084 UR - https://www.unboundmedicine.com/medline/citation/24078055/3_T_breast_magnetic_resonance_imaging_in_patients_with_suspicious_microcalcifications_on_mammography_ L2 - https://dx.doi.org/10.1007/s00330-013-3029-1 DB - PRIME DP - Unbound Medicine ER -