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Anodal transcranial direct current stimulation (tDCS) over the motor cortex increases sympathetic nerve activity.
Brain Stimul 2014 Jan-Feb; 7(1):97-104BS

Abstract

BACKGROUND

Transcranial direct current stimulation (tDCS) is currently being investigated as a non-invasive neuromodulation therapy for a range of conditions including stroke rehabilitation. tDCS affects not only the area underlying the electrodes but also other areas of the cortex and subcortical structures. This could lead to unintended alteration in brain functions such as autonomic control.

OBJECTIVE

We investigated the potential effects of tDCS on cardiovascular autonomic function in healthy volunteers.

METHODS

Anodal (n = 14) or cathodal (n = 8) tDCS at 1 mA was applied over the primary motor cortex with the second electrode placed on the contralateral supraorbital region. Subjects visited the department twice and received active or sham tDCS for 15 min. Heart rate, blood pressure and respiration were recorded at baseline, during tDCS and after stimulation. Heart rate variability (HRV) was calculated using spectral analysis of beat-to-beat intervals derived from ECG data. Microneurography was also used to record muscle sympathetic nerve activity (MSNA; n = 5).

RESULTS

Anodal tDCS caused a significant shift in HRV toward sympathetic predominance (P = 0.017), whereas there was no significant change in the cathodal or sham groups. Microneurography results also showed a significant increase in MSNA during anodal tDCS that continued post-stimulation.

CONCLUSIONS

Anodal tDCS of the motor cortex shifts autonomic nervous system balance toward sympathetic dominance due at least in part to an increase in sympathetic output. These results suggest further investigation is warranted on tDCS use in patient groups with potential autonomic dysfunction, such as stroke patients.

Authors+Show Affiliations

School of Biomedical Sciences, University of Leeds, Garstang Building, Leeds LS2 9JT, UK.Institute of Psychological Sciences, University of Leeds, Leeds LS2 9JT, UK.Institute of Psychological Sciences, University of Leeds, Leeds LS2 9JT, UK.School of Biomedical Sciences, University of Leeds, Garstang Building, Leeds LS2 9JT, UK.School of Biomedical Sciences, University of Leeds, Garstang Building, Leeds LS2 9JT, UK. Electronic address: J.Deuchars@leeds.ac.uk.

Pub Type(s)

Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

24080439

Citation

Clancy, Jennifer A., et al. "Anodal Transcranial Direct Current Stimulation (tDCS) Over the Motor Cortex Increases Sympathetic Nerve Activity." Brain Stimulation, vol. 7, no. 1, 2014, pp. 97-104.
Clancy JA, Johnson R, Raw R, et al. Anodal transcranial direct current stimulation (tDCS) over the motor cortex increases sympathetic nerve activity. Brain Stimul. 2014;7(1):97-104.
Clancy, J. A., Johnson, R., Raw, R., Deuchars, S. A., & Deuchars, J. (2014). Anodal transcranial direct current stimulation (tDCS) over the motor cortex increases sympathetic nerve activity. Brain Stimulation, 7(1), pp. 97-104. doi:10.1016/j.brs.2013.08.005.
Clancy JA, et al. Anodal Transcranial Direct Current Stimulation (tDCS) Over the Motor Cortex Increases Sympathetic Nerve Activity. Brain Stimul. 2014;7(1):97-104. PubMed PMID: 24080439.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Anodal transcranial direct current stimulation (tDCS) over the motor cortex increases sympathetic nerve activity. AU - Clancy,Jennifer A, AU - Johnson,Robyn, AU - Raw,Rachael, AU - Deuchars,Susan A, AU - Deuchars,Jim, Y1 - 2013/09/18/ PY - 2013/05/08/received PY - 2013/08/19/revised PY - 2013/08/23/accepted PY - 2013/10/2/entrez PY - 2013/10/2/pubmed PY - 2014/8/26/medline KW - Autonomic nervous system KW - Microneurography KW - Sympathetic nerve activity KW - Transcranial direct current stimulation (tDCS) SP - 97 EP - 104 JF - Brain stimulation JO - Brain Stimul VL - 7 IS - 1 N2 - BACKGROUND: Transcranial direct current stimulation (tDCS) is currently being investigated as a non-invasive neuromodulation therapy for a range of conditions including stroke rehabilitation. tDCS affects not only the area underlying the electrodes but also other areas of the cortex and subcortical structures. This could lead to unintended alteration in brain functions such as autonomic control. OBJECTIVE: We investigated the potential effects of tDCS on cardiovascular autonomic function in healthy volunteers. METHODS: Anodal (n = 14) or cathodal (n = 8) tDCS at 1 mA was applied over the primary motor cortex with the second electrode placed on the contralateral supraorbital region. Subjects visited the department twice and received active or sham tDCS for 15 min. Heart rate, blood pressure and respiration were recorded at baseline, during tDCS and after stimulation. Heart rate variability (HRV) was calculated using spectral analysis of beat-to-beat intervals derived from ECG data. Microneurography was also used to record muscle sympathetic nerve activity (MSNA; n = 5). RESULTS: Anodal tDCS caused a significant shift in HRV toward sympathetic predominance (P = 0.017), whereas there was no significant change in the cathodal or sham groups. Microneurography results also showed a significant increase in MSNA during anodal tDCS that continued post-stimulation. CONCLUSIONS: Anodal tDCS of the motor cortex shifts autonomic nervous system balance toward sympathetic dominance due at least in part to an increase in sympathetic output. These results suggest further investigation is warranted on tDCS use in patient groups with potential autonomic dysfunction, such as stroke patients. SN - 1876-4754 UR - https://www.unboundmedicine.com/medline/citation/24080439/Anodal_transcranial_direct_current_stimulation__tDCS__over_the_motor_cortex_increases_sympathetic_nerve_activity_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1935-861X(13)00275-1 DB - PRIME DP - Unbound Medicine ER -