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Green tea catechins: a fresh flavor to anticancer therapy.
Apoptosis. 2014 Jan; 19(1):1-18.A

Abstract

Green tea catechins have been extensively studied for their cancer preventive effects. Accumulating evidence has shown that green tea catechins, like (-)-epigallocatechin-3-gallate, have strong anti-oxidant activity and affect several signal transduction pathways relevant to cancer development. Here, we review the biological properties of green tea catechins and the molecular mechanisms of their anticancer effects, including the suppression of cancer cell proliferation, induction of apoptosis, and inhibition of tumor metastasis and angiogenesis. We summarize the efficacy of a single catechin and the synergetic effects of multiple catechins. We also discuss the enhanced anticancer effects of green tea catechins when they are combined with anticancer drugs. The information present in this review might promote the development of strategy for the co-administration of green tea catechins with other anticancer drugs to increase the potency of currently available anticancer medicine. This new strategy should in turn lower the cytotoxicity and cost of anticancer treatment.

Authors+Show Affiliations

School of Life Sciences and Key Laboratory of Bio-resources, Ministry of Education, Sichuan University, Chengdu, 610064, China.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

24081390

Citation

Yu, Yang, et al. "Green Tea Catechins: a Fresh Flavor to Anticancer Therapy." Apoptosis : an International Journal On Programmed Cell Death, vol. 19, no. 1, 2014, pp. 1-18.
Yu Y, Deng Y, Lu BM, et al. Green tea catechins: a fresh flavor to anticancer therapy. Apoptosis. 2014;19(1):1-18.
Yu, Y., Deng, Y., Lu, B. M., Liu, Y. X., Li, J., & Bao, J. K. (2014). Green tea catechins: a fresh flavor to anticancer therapy. Apoptosis : an International Journal On Programmed Cell Death, 19(1), 1-18. https://doi.org/10.1007/s10495-013-0908-5
Yu Y, et al. Green Tea Catechins: a Fresh Flavor to Anticancer Therapy. Apoptosis. 2014;19(1):1-18. PubMed PMID: 24081390.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Green tea catechins: a fresh flavor to anticancer therapy. AU - Yu,Yang, AU - Deng,Yuan, AU - Lu,Bang-Min, AU - Liu,Yong-Xi, AU - Li,Jian, AU - Bao,Jin-Ku, PY - 2013/10/2/entrez PY - 2013/10/2/pubmed PY - 2014/9/3/medline SP - 1 EP - 18 JF - Apoptosis : an international journal on programmed cell death JO - Apoptosis VL - 19 IS - 1 N2 - Green tea catechins have been extensively studied for their cancer preventive effects. Accumulating evidence has shown that green tea catechins, like (-)-epigallocatechin-3-gallate, have strong anti-oxidant activity and affect several signal transduction pathways relevant to cancer development. Here, we review the biological properties of green tea catechins and the molecular mechanisms of their anticancer effects, including the suppression of cancer cell proliferation, induction of apoptosis, and inhibition of tumor metastasis and angiogenesis. We summarize the efficacy of a single catechin and the synergetic effects of multiple catechins. We also discuss the enhanced anticancer effects of green tea catechins when they are combined with anticancer drugs. The information present in this review might promote the development of strategy for the co-administration of green tea catechins with other anticancer drugs to increase the potency of currently available anticancer medicine. This new strategy should in turn lower the cytotoxicity and cost of anticancer treatment. SN - 1573-675X UR - https://www.unboundmedicine.com/medline/citation/24081390/Green_tea_catechins:_a_fresh_flavor_to_anticancer_therapy_ L2 - https://doi.org/10.1007/s10495-013-0908-5 DB - PRIME DP - Unbound Medicine ER -