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Gestational diabetes and type 2 diabetes in reproductive-aged women with polycystic ovary syndrome.

Abstract

CONTEXT

Polycystic ovary syndrome (PCOS) affects 6%-21% of women. PCOS has been associated with an increased risk of dysglycemia including gestational diabetes mellitus (GDM) and type 2 diabetes mellitus (T2DM).

OBJECTIVE

The objective of the study was to assess the prevalence of dysglycemia and the impact of obesity in young reproductive-aged women with and without PCOS in a community-based cohort.

DESIGN

This was a cross-sectional analysis of data from a large longitudinal study (the Australian Longitudinal Study on Women's Health).

SETTING

The setting for the study was the general community.

PARTICIPANTS

Women were randomly selected from the national health insurance database. Standardized data collection occurred at five survey time points (years 1996, 2000, 2003, 2006, and 2009). Data from survey 4 (2006, n = 9145, 62% of original cohort aged 18-23 y) were examined for this study.

MAIN OUTCOME MEASURES

Self-reported PCOS, GDM, and T2DM were measured.

RESULTS

In women aged 28-33 years, PCOS prevalence was 5.8% [95% confidence interval (CI) 5.3%-6.4%]. The prevalence of GDM (in women reporting prior pregnancy) and T2DM was 11.2% and 5.1% in women with PCOS and 3.8% and 0.3% in women without PCOS, respectively (P for both < .001). PCOS was associated with an increased odds of GDM and T2DM. After adjusting for age, body mass index, hypertension, smoking, and demographic factors, the odds of GDM (odds ratio 2.1, 95% CI 1.1-3.9, P = .02) and T2DM (odds ratio 8.8, 95% CI 3.9-20.1, P < .001) remained increased in women reporting PCOS.

CONCLUSIONS

In a large community-based cohort of reproductive-aged women, PCOS was independently associated with a higher risk of GDM and T2DM, independent of body mass index. Aggressive screening, prevention, and management of dysglycemia is clearly warranted in women with PCOS.

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  • Authors+Show Affiliations

    ,

    Monash Centre for Health Research and Implementation, School of Public Health and Preventive Medicine, (A.E.J., S.R., S.Z., L.M., H.J.T.), Monash University, and Southern Health, Clayton, Victoria 3168, Australia; and The Robinson Institute (L.M.), University of Adelaide, North Adelaide, SA 5006, Australia.

    , , ,

    Source

    MeSH

    Adolescent
    Adult
    Body Mass Index
    Cohort Studies
    Cross-Sectional Studies
    Diabetes Mellitus, Type 2
    Diabetes, Gestational
    Female
    Humans
    Obesity
    Polycystic Ovary Syndrome
    Pregnancy
    Pregnancy in Diabetics
    Young Adult

    Pub Type(s)

    Journal Article
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    24081730

    Citation

    Joham, A E., et al. "Gestational Diabetes and Type 2 Diabetes in Reproductive-aged Women With Polycystic Ovary Syndrome." The Journal of Clinical Endocrinology and Metabolism, vol. 99, no. 3, 2014, pp. E447-52.
    Joham AE, Ranasinha S, Zoungas S, et al. Gestational diabetes and type 2 diabetes in reproductive-aged women with polycystic ovary syndrome. J Clin Endocrinol Metab. 2014;99(3):E447-52.
    Joham, A. E., Ranasinha, S., Zoungas, S., Moran, L., & Teede, H. J. (2014). Gestational diabetes and type 2 diabetes in reproductive-aged women with polycystic ovary syndrome. The Journal of Clinical Endocrinology and Metabolism, 99(3), pp. E447-52. doi:10.1210/jc.2013-2007.
    Joham AE, et al. Gestational Diabetes and Type 2 Diabetes in Reproductive-aged Women With Polycystic Ovary Syndrome. J Clin Endocrinol Metab. 2014;99(3):E447-52. PubMed PMID: 24081730.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Gestational diabetes and type 2 diabetes in reproductive-aged women with polycystic ovary syndrome. AU - Joham,A E, AU - Ranasinha,S, AU - Zoungas,S, AU - Moran,L, AU - Teede,H J, Y1 - 2013/09/30/ PY - 2013/10/2/entrez PY - 2013/10/2/pubmed PY - 2014/7/16/medline SP - E447 EP - 52 JF - The Journal of clinical endocrinology and metabolism JO - J. Clin. Endocrinol. Metab. VL - 99 IS - 3 N2 - CONTEXT: Polycystic ovary syndrome (PCOS) affects 6%-21% of women. PCOS has been associated with an increased risk of dysglycemia including gestational diabetes mellitus (GDM) and type 2 diabetes mellitus (T2DM). OBJECTIVE: The objective of the study was to assess the prevalence of dysglycemia and the impact of obesity in young reproductive-aged women with and without PCOS in a community-based cohort. DESIGN: This was a cross-sectional analysis of data from a large longitudinal study (the Australian Longitudinal Study on Women's Health). SETTING: The setting for the study was the general community. PARTICIPANTS: Women were randomly selected from the national health insurance database. Standardized data collection occurred at five survey time points (years 1996, 2000, 2003, 2006, and 2009). Data from survey 4 (2006, n = 9145, 62% of original cohort aged 18-23 y) were examined for this study. MAIN OUTCOME MEASURES: Self-reported PCOS, GDM, and T2DM were measured. RESULTS: In women aged 28-33 years, PCOS prevalence was 5.8% [95% confidence interval (CI) 5.3%-6.4%]. The prevalence of GDM (in women reporting prior pregnancy) and T2DM was 11.2% and 5.1% in women with PCOS and 3.8% and 0.3% in women without PCOS, respectively (P for both < .001). PCOS was associated with an increased odds of GDM and T2DM. After adjusting for age, body mass index, hypertension, smoking, and demographic factors, the odds of GDM (odds ratio 2.1, 95% CI 1.1-3.9, P = .02) and T2DM (odds ratio 8.8, 95% CI 3.9-20.1, P < .001) remained increased in women reporting PCOS. CONCLUSIONS: In a large community-based cohort of reproductive-aged women, PCOS was independently associated with a higher risk of GDM and T2DM, independent of body mass index. Aggressive screening, prevention, and management of dysglycemia is clearly warranted in women with PCOS. SN - 1945-7197 UR - https://www.unboundmedicine.com/medline/citation/24081730/Gestational_diabetes_and_type_2_diabetes_in_reproductive_aged_women_with_polycystic_ovary_syndrome_ L2 - https://academic.oup.com/jcem/article-lookup/doi/10.1210/jc.2013-2007 DB - PRIME DP - Unbound Medicine ER -