Gestational diabetes and type 2 diabetes in reproductive-aged women with polycystic ovary syndrome.
CONTEXTPolycystic ovary syndrome (PCOS) affects 6%-21% of women. PCOS has been associated with an increased risk of dysglycemia including gestational diabetes mellitus (GDM) and type 2 diabetes mellitus (T2DM).
OBJECTIVEThe objective of the study was to assess the prevalence of dysglycemia and the impact of obesity in young reproductive-aged women with and without PCOS in a community-based cohort.
DESIGNThis was a cross-sectional analysis of data from a large longitudinal study (the Australian Longitudinal Study on Women's Health).
SETTINGThe setting for the study was the general community.
PARTICIPANTSWomen were randomly selected from the national health insurance database. Standardized data collection occurred at five survey time points (years 1996, 2000, 2003, 2006, and 2009). Data from survey 4 (2006, n = 9145, 62% of original cohort aged 18-23 y) were examined for this study.
MAIN OUTCOME MEASURESSelf-reported PCOS, GDM, and T2DM were measured.
RESULTSIn women aged 28-33 years, PCOS prevalence was 5.8% [95% confidence interval (CI) 5.3%-6.4%]. The prevalence of GDM (in women reporting prior pregnancy) and T2DM was 11.2% and 5.1% in women with PCOS and 3.8% and 0.3% in women without PCOS, respectively (P for both < .001). PCOS was associated with an increased odds of GDM and T2DM. After adjusting for age, body mass index, hypertension, smoking, and demographic factors, the odds of GDM (odds ratio 2.1, 95% CI 1.1-3.9, P = .02) and T2DM (odds ratio 8.8, 95% CI 3.9-20.1, P < .001) remained increased in women reporting PCOS.
CONCLUSIONSIn a large community-based cohort of reproductive-aged women, PCOS was independently associated with a higher risk of GDM and T2DM, independent of body mass index. Aggressive screening, prevention, and management of dysglycemia is clearly warranted in women with PCOS.
Monash Centre for Health Research and Implementation, School of Public Health and Preventive Medicine, (A.E.J., S.R., S.Z., L.M., H.J.T.), Monash University, and Southern Health, Clayton, Victoria 3168, Australia; and The Robinson Institute (L.M.), University of Adelaide, North Adelaide, SA 5006, Australia., , ,
Body Mass Index
Diabetes Mellitus, Type 2
Polycystic Ovary Syndrome
Pregnancy in Diabetics
Pub Type(s)Journal Article
Research Support, Non-U.S. Gov't