TY - JOUR T1 - Prevalence and severity of oral disease in adults with chronic kidney disease: a systematic review of observational studies. AU - Ruospo,Marinella, AU - Palmer,Suetonia C, AU - Craig,Jonathan C, AU - Gentile,Giorgio, AU - Johnson,David W, AU - Ford,Pauline J, AU - Tonelli,Marcello, AU - Petruzzi,Massimo, AU - De Benedittis,Michele, AU - Strippoli,Giovanni F M, Y1 - 2013/09/29/ PY - 2013/10/2/entrez PY - 2013/10/2/pubmed PY - 2014/10/15/medline KW - chronic kidney disease KW - epidemiology KW - meta-analysis KW - oral health KW - periodontitis SP - 364 EP - 75 JF - Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association JO - Nephrol Dial Transplant VL - 29 IS - 2 N2 - BACKGROUND: Oral disease may be increased in people with chronic kidney disease (CKD) and, due to associations with inflammation and malnutrition, represents a potential modifiable risk factor for cardiovascular disease and mortality. We summarized the prevalence of oral disease in adults with CKD and explored any association between oral disease and mortality. METHODS: We used systematic review of observational studies evaluating oral health in adults with CKD identified in MEDLINE (through September 2012) without language restriction. We summarized prevalence and associations with all-cause and cardiovascular mortality using random-effects meta-analysis. We explored for sources of heterogeneity between studies using meta-regression. RESULTS: Eighty-eight studies in 125 populations comprising 11 340 adults were eligible. Edentulism affected one in five adults with CKD Stage 5D (dialysis) {20.6% [95% confidence interval (CI), 16.4-25.6]}. Periodontitis was more common in CKD Stage 5D [56.8% (CI, 39.3-72.8)] than less severe CKD [31.6% (CI, 19.0-47.6)], although data linking periodontitis with premature death were scant. One-quarter of patients with CKD Stage 5D reported never brushing their teeth [25.6% (CI, 10.2-51.1)] and a minority used dental floss [11.4% (CI, 6.2-19.8)]; oral pain was reported by one-sixth [18.7% (CI, 8.8-35.4)], while half of patients experienced a dry mouth [48.4% (CI, 37.5-59.5)]. Data for kidney transplant recipients and CKD Stages 1-5 were limited. CONCLUSIONS: Oral disease is common in adults with CKD, potentially reflects low use of preventative dental services, and may be an important determinant of health in this clinical setting. SN - 1460-2385 UR - https://www.unboundmedicine.com/medline/citation/24081863/Prevalence_and_severity_of_oral_disease_in_adults_with_chronic_kidney_disease:_a_systematic_review_of_observational_studies_ L2 - https://academic.oup.com/ndt/article-lookup/doi/10.1093/ndt/gft401 DB - PRIME DP - Unbound Medicine ER -