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Protective role of Artemisia afra aqueous extract on tissue antioxidant defense systems in streptozotocin-induced diabetic rats.

Abstract

Changes in antioxidant capacity in the body as a result of oxidative stress play an important role in the development of diabetic complications. The aim of this study was to evaluate the effect of aqueous extract of Artemisia afra Jacq. ex Willd. on antioxidant defense systems in the liver and kidney of streptozotocin-induced diabetic rats. Administration of the extract to diabetic rats for 21 days significantly reduced blood glucose levels and increased body weight. The diabetic animals exhibited decreased levels of glutathione reductase (GR), glutathione peroxidase (GPx), superoxide dismutase (SOD) and reduced glutathione (GSH) in the liver and kidney, which were restored to near normal levels following treatment with the herb. The increased levels of lipid peroxidation observed in the tissues of diabetic rats were also reverted back to near normalcy after administering the extract. These findings revealed the protective role of A. afra on tissues by reducing oxidative stress which could be attributed to its flavonoids content. The efficacy of the plant compared favourably well with glibenclamide, a standard hypoglycemic drug.

Authors+Show Affiliations

Phytomedicine Research Center, Department of Botany, University of Fort Hare, Alice 5700, South Africa.No affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

24082320

Citation

Afolayan, Anthony Jide, and Taofik Olatunde Sunmonu. "Protective Role of Artemisia Afra Aqueous Extract On Tissue Antioxidant Defense Systems in Streptozotocin-induced Diabetic Rats." African Journal of Traditional, Complementary, and Alternative Medicines : AJTCAM, vol. 10, no. 1, 2012, pp. 15-20.
Afolayan AJ, Sunmonu TO. Protective role of Artemisia afra aqueous extract on tissue antioxidant defense systems in streptozotocin-induced diabetic rats. Afr J Tradit Complement Altern Med. 2012;10(1):15-20.
Afolayan, A. J., & Sunmonu, T. O. (2012). Protective role of Artemisia afra aqueous extract on tissue antioxidant defense systems in streptozotocin-induced diabetic rats. African Journal of Traditional, Complementary, and Alternative Medicines : AJTCAM, 10(1), 15-20.
Afolayan AJ, Sunmonu TO. Protective Role of Artemisia Afra Aqueous Extract On Tissue Antioxidant Defense Systems in Streptozotocin-induced Diabetic Rats. Afr J Tradit Complement Altern Med. 2012;10(1):15-20. PubMed PMID: 24082320.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Protective role of Artemisia afra aqueous extract on tissue antioxidant defense systems in streptozotocin-induced diabetic rats. AU - Afolayan,Anthony Jide, AU - Sunmonu,Taofik Olatunde, Y1 - 2012/10/01/ PY - 2013/10/2/entrez PY - 2012/1/1/pubmed PY - 2014/4/9/medline KW - Artemisia afra KW - antioxidant KW - diabetes KW - flavonoids KW - free radicals KW - oxidative stress SP - 15 EP - 20 JF - African journal of traditional, complementary, and alternative medicines : AJTCAM JO - Afr J Tradit Complement Altern Med VL - 10 IS - 1 N2 - Changes in antioxidant capacity in the body as a result of oxidative stress play an important role in the development of diabetic complications. The aim of this study was to evaluate the effect of aqueous extract of Artemisia afra Jacq. ex Willd. on antioxidant defense systems in the liver and kidney of streptozotocin-induced diabetic rats. Administration of the extract to diabetic rats for 21 days significantly reduced blood glucose levels and increased body weight. The diabetic animals exhibited decreased levels of glutathione reductase (GR), glutathione peroxidase (GPx), superoxide dismutase (SOD) and reduced glutathione (GSH) in the liver and kidney, which were restored to near normal levels following treatment with the herb. The increased levels of lipid peroxidation observed in the tissues of diabetic rats were also reverted back to near normalcy after administering the extract. These findings revealed the protective role of A. afra on tissues by reducing oxidative stress which could be attributed to its flavonoids content. The efficacy of the plant compared favourably well with glibenclamide, a standard hypoglycemic drug. SN - 2505-0044 UR - https://www.unboundmedicine.com/medline/citation/24082320/Protective_role_of_Artemisia_afra_aqueous_extract_on_tissue_antioxidant_defense_systems_in_streptozotocin_induced_diabetic_rats_ L2 - https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24082320/ DB - PRIME DP - Unbound Medicine ER -