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Vitamin D insufficiency and deficiency with stages of chronic kidney disease in an Asian population.
BMC Nephrol. 2013 Oct 02; 14:206.BN

Abstract

BACKGROUND

Vitamin D insufficiency is associated with proteinuria and could be a risk factor for end-stage renal disease (ESRD). However, few studies have examined the significance of vitamin D insufficiency as a contributing factor for the development of ESRD in the Asian chronic kidney disease (CKD) population.

METHODS

Authors examined the relationship between vitamin D status and the staging of CKD using data from an outpatient clinic-based screening in 2,895 Thai CKD patients. Serum levels of 25-hydroxyvitamin D were analyzed according to CKD stages. Vitamin D deficiency and insufficiency were defined as a serum 25-hydroxyvitamin D concentration < 10 ng/mL and 10-30 ng/mL, respectively.

RESULTS

The mean (SD) 25-hydroxyvitamin D levels were significantly lower according to severity of renal impairment (CKD stage 3a: 27.84 ± 14.03 ng/mL, CKD stage 3b: 25.86 ± 11.14 ng/mL, CKD stage 4: 24.09 ± 11.65 and CKD stage 5: 20.82 ± 9.86 ng/mL, p<0.001). The prevalence of vitamin D deficiency/insufficiency was from CKD stage 3a, 3b, 4 to 5, 66.6%, 70.9%, 74.6%, and 84.7% (p<0.001). The odds ratio (95% CI) of vitamin D insufficiency/deficiency (serum 25-hydroxyvitamin D ≤ 30 ng/mL) and vitamin D deficiency (serum 25-hydroxyvitamin D < 10 ng/mL) for developing ESRD, after adjustment for age, gender, hemoglobin, serum albumin, calcium, phosphate and alkaline phosphatase were 2.19 (95% CI 1.07 to 4.48) and 16.76 (95% CI 4.89 to 57.49), respectively.

CONCLUSION

This study demonstrates that 25-hydroxyvitamin D insufficiency and deficiency are more common and associated with the level of kidney function in the Thai CKD population especially advanced stage of CKD.

Authors+Show Affiliations

Division of Nephrology, Department of Medicine, Phramongkutklao Hospital, Bangkok, Thailand. satirapoj@yahoo.com.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

24083392

Citation

Satirapoj, Bancha, et al. "Vitamin D Insufficiency and Deficiency With Stages of Chronic Kidney Disease in an Asian Population." BMC Nephrology, vol. 14, 2013, p. 206.
Satirapoj B, Limwannata P, Chaiprasert A, et al. Vitamin D insufficiency and deficiency with stages of chronic kidney disease in an Asian population. BMC Nephrol. 2013;14:206.
Satirapoj, B., Limwannata, P., Chaiprasert, A., Supasyndh, O., & Choovichian, P. (2013). Vitamin D insufficiency and deficiency with stages of chronic kidney disease in an Asian population. BMC Nephrology, 14, 206. https://doi.org/10.1186/1471-2369-14-206
Satirapoj B, et al. Vitamin D Insufficiency and Deficiency With Stages of Chronic Kidney Disease in an Asian Population. BMC Nephrol. 2013 Oct 2;14:206. PubMed PMID: 24083392.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Vitamin D insufficiency and deficiency with stages of chronic kidney disease in an Asian population. AU - Satirapoj,Bancha, AU - Limwannata,Pokkrong, AU - Chaiprasert,Amnart, AU - Supasyndh,Ouppatham, AU - Choovichian,Panbuppa, Y1 - 2013/10/02/ PY - 2013/07/05/received PY - 2013/10/01/accepted PY - 2013/10/3/entrez PY - 2013/10/3/pubmed PY - 2014/7/23/medline SP - 206 EP - 206 JF - BMC nephrology JO - BMC Nephrol VL - 14 N2 - BACKGROUND: Vitamin D insufficiency is associated with proteinuria and could be a risk factor for end-stage renal disease (ESRD). However, few studies have examined the significance of vitamin D insufficiency as a contributing factor for the development of ESRD in the Asian chronic kidney disease (CKD) population. METHODS: Authors examined the relationship between vitamin D status and the staging of CKD using data from an outpatient clinic-based screening in 2,895 Thai CKD patients. Serum levels of 25-hydroxyvitamin D were analyzed according to CKD stages. Vitamin D deficiency and insufficiency were defined as a serum 25-hydroxyvitamin D concentration < 10 ng/mL and 10-30 ng/mL, respectively. RESULTS: The mean (SD) 25-hydroxyvitamin D levels were significantly lower according to severity of renal impairment (CKD stage 3a: 27.84 ± 14.03 ng/mL, CKD stage 3b: 25.86 ± 11.14 ng/mL, CKD stage 4: 24.09 ± 11.65 and CKD stage 5: 20.82 ± 9.86 ng/mL, p<0.001). The prevalence of vitamin D deficiency/insufficiency was from CKD stage 3a, 3b, 4 to 5, 66.6%, 70.9%, 74.6%, and 84.7% (p<0.001). The odds ratio (95% CI) of vitamin D insufficiency/deficiency (serum 25-hydroxyvitamin D ≤ 30 ng/mL) and vitamin D deficiency (serum 25-hydroxyvitamin D < 10 ng/mL) for developing ESRD, after adjustment for age, gender, hemoglobin, serum albumin, calcium, phosphate and alkaline phosphatase were 2.19 (95% CI 1.07 to 4.48) and 16.76 (95% CI 4.89 to 57.49), respectively. CONCLUSION: This study demonstrates that 25-hydroxyvitamin D insufficiency and deficiency are more common and associated with the level of kidney function in the Thai CKD population especially advanced stage of CKD. SN - 1471-2369 UR - https://www.unboundmedicine.com/medline/citation/24083392/Vitamin_D_insufficiency_and_deficiency_with_stages_of_chronic_kidney_disease_in_an_Asian_population_ L2 - https://www.biomedcentral.com/1471-2369/14/206 DB - PRIME DP - Unbound Medicine ER -