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Omega-3 polyunsaturated fatty acids for major depressive disorder.
Expert Opin Investig Drugs. 2013 Dec; 22(12):1519-34.EO

Abstract

INTRODUCTION

Omega-3 polyunsaturated fatty acids (omega-3 PUFAs) are not synthesized by the human body; they must be derived from dietary sources and they have been known to be involved with neurological, cardiovascular, cerebrovascular, autoimmune and metabolic diseases, and cognitive disorder as well as mood disorders.

AREAS COVERED

A number of epidemiological and preclinical studies have proven the potential benefit and critical role of omega-3 PUFA in the development and management of major depressive disorder (MDD). In addition, recently independent clinical trials and meta-analyses have also provided superidority of omega-3 PUFA over placebo as monotherapy or augmentation agent in the treatment of MDD. This article presents a brief overview of the evidence to date about the clinical application and biological mechanisms of omega-3 PUFA in the treatment of MDD.

EXPERT OPINION

Given the potential action mechanism, clinical benefits and currently available clinical trial data, omega-3 PUFAs may deserve greater attention and wider application for treatment of MDD. However, the practical utility of omega-3 PUFA as one of promising alternative agent for treatment of MDD still have many questions unresolved to be fully addressed in near future.

Authors+Show Affiliations

China Medical University, School of Medicine & Graduate Institute of Neural and Cognitive Sciences , Taichung , Taiwan.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

24083675

Citation

Su, Kuan-Pin, et al. "Omega-3 Polyunsaturated Fatty Acids for Major Depressive Disorder." Expert Opinion On Investigational Drugs, vol. 22, no. 12, 2013, pp. 1519-34.
Su KP, Wang SM, Pae CU. Omega-3 polyunsaturated fatty acids for major depressive disorder. Expert Opin Investig Drugs. 2013;22(12):1519-34.
Su, K. P., Wang, S. M., & Pae, C. U. (2013). Omega-3 polyunsaturated fatty acids for major depressive disorder. Expert Opinion On Investigational Drugs, 22(12), 1519-34. https://doi.org/10.1517/13543784.2013.836487
Su KP, Wang SM, Pae CU. Omega-3 Polyunsaturated Fatty Acids for Major Depressive Disorder. Expert Opin Investig Drugs. 2013;22(12):1519-34. PubMed PMID: 24083675.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Omega-3 polyunsaturated fatty acids for major depressive disorder. AU - Su,Kuan-Pin, AU - Wang,Sheng-Min, AU - Pae,Chi-Un, Y1 - 2013/10/02/ PY - 2013/10/3/entrez PY - 2013/10/3/pubmed PY - 2014/6/18/medline SP - 1519 EP - 34 JF - Expert opinion on investigational drugs JO - Expert Opin Investig Drugs VL - 22 IS - 12 N2 - INTRODUCTION: Omega-3 polyunsaturated fatty acids (omega-3 PUFAs) are not synthesized by the human body; they must be derived from dietary sources and they have been known to be involved with neurological, cardiovascular, cerebrovascular, autoimmune and metabolic diseases, and cognitive disorder as well as mood disorders. AREAS COVERED: A number of epidemiological and preclinical studies have proven the potential benefit and critical role of omega-3 PUFA in the development and management of major depressive disorder (MDD). In addition, recently independent clinical trials and meta-analyses have also provided superidority of omega-3 PUFA over placebo as monotherapy or augmentation agent in the treatment of MDD. This article presents a brief overview of the evidence to date about the clinical application and biological mechanisms of omega-3 PUFA in the treatment of MDD. EXPERT OPINION: Given the potential action mechanism, clinical benefits and currently available clinical trial data, omega-3 PUFAs may deserve greater attention and wider application for treatment of MDD. However, the practical utility of omega-3 PUFA as one of promising alternative agent for treatment of MDD still have many questions unresolved to be fully addressed in near future. SN - 1744-7658 UR - https://www.unboundmedicine.com/medline/citation/24083675/Omega_3_polyunsaturated_fatty_acids_for_major_depressive_disorder_ L2 - https://www.tandfonline.com/doi/full/10.1517/13543784.2013.836487 DB - PRIME DP - Unbound Medicine ER -