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Dairy products consumption and risk of type 2 diabetes: systematic review and dose-response meta-analysis.
PLoS One 2013; 8(9):e73965Plos

Abstract

BACKGROUND

The consumption of dairy products may influence the risk of type 2 diabetes mellitus (T2DM), but inconsistent findings have been reported. Moreover, large variation in the types of dairy intake has not yet been fully explored.

METHODS AND RESULTS

We conducted a systematic review and meta-analysis to clarify the dose-response association of dairy products intake and T2DM risk. We searched PubMed, EMBASE and Scopus for studies of dairy products intake and T2DM risk published up to the end of October 2012. Random-effects models were used to estimate summary relative risk (RR) statistics. Dose-response relations were evaluated using data from different dairy products in each study. We included 14 articles of cohort studies that reported RR estimates and 95% confidence intervals (95% CIs) of T2DM with dairy products intake. We found an inverse linear association of consumption of total dairy products (13 studies), low-fat dairy products (8 studies), cheese (7 studies) and yogurt (7 studies) and risk of T2DM. The pooled RRs were 0.94 (95% CI 0.91-0.97) and 0.88 (0.84-0.93) for 200 g/day total and low-fat dairy consumption, respectively. The pooled RRs were 0.80 (0.69-0.93) and 0.91 (0.82-1.00) for 30 g/d cheese and 50 g/d yogurt consumption, respectively. We also found a nonlinear association of total and low-fat dairy intake and T2DM risk, and the inverse association appeared to be strongest within 200 g/d intake.

CONCLUSION

A modest increase in daily intake of dairy products such as low fat dairy, cheese and yogurt may contribute to the prevention of T2DM, which needs confirmation in randomized controlled trials.

Authors+Show Affiliations

Department of Cardiology, The Second Affiliated Hospital, Xi'an Jiaotong University School of Medicine, Xi'an, Shaanxi, P.R. China ; Key Laboratory of Environment and Genes Related to Diseases (Xi'an Jiaotong University), Ministry of Education, Xi'an, Shaanxi, P. R. China.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Meta-Analysis
Research Support, Non-U.S. Gov't
Review
Systematic Review

Language

eng

PubMed ID

24086304

Citation

Gao, Dengfeng, et al. "Dairy Products Consumption and Risk of Type 2 Diabetes: Systematic Review and Dose-response Meta-analysis." PloS One, vol. 8, no. 9, 2013, pp. e73965.
Gao D, Ning N, Wang C, et al. Dairy products consumption and risk of type 2 diabetes: systematic review and dose-response meta-analysis. PLoS ONE. 2013;8(9):e73965.
Gao, D., Ning, N., Wang, C., Wang, Y., Li, Q., Meng, Z., ... Li, Q. (2013). Dairy products consumption and risk of type 2 diabetes: systematic review and dose-response meta-analysis. PloS One, 8(9), pp. e73965. doi:10.1371/journal.pone.0073965.
Gao D, et al. Dairy Products Consumption and Risk of Type 2 Diabetes: Systematic Review and Dose-response Meta-analysis. PLoS ONE. 2013;8(9):e73965. PubMed PMID: 24086304.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Dairy products consumption and risk of type 2 diabetes: systematic review and dose-response meta-analysis. AU - Gao,Dengfeng, AU - Ning,Ning, AU - Wang,Congxia, AU - Wang,Yuhuan, AU - Li,Qing, AU - Meng,Zhe, AU - Liu,Yang, AU - Li,Qiang, Y1 - 2013/09/27/ PY - 2013/03/01/received PY - 2013/07/25/accepted PY - 2013/10/3/entrez PY - 2013/10/3/pubmed PY - 2014/7/19/medline SP - e73965 EP - e73965 JF - PloS one JO - PLoS ONE VL - 8 IS - 9 N2 - BACKGROUND: The consumption of dairy products may influence the risk of type 2 diabetes mellitus (T2DM), but inconsistent findings have been reported. Moreover, large variation in the types of dairy intake has not yet been fully explored. METHODS AND RESULTS: We conducted a systematic review and meta-analysis to clarify the dose-response association of dairy products intake and T2DM risk. We searched PubMed, EMBASE and Scopus for studies of dairy products intake and T2DM risk published up to the end of October 2012. Random-effects models were used to estimate summary relative risk (RR) statistics. Dose-response relations were evaluated using data from different dairy products in each study. We included 14 articles of cohort studies that reported RR estimates and 95% confidence intervals (95% CIs) of T2DM with dairy products intake. We found an inverse linear association of consumption of total dairy products (13 studies), low-fat dairy products (8 studies), cheese (7 studies) and yogurt (7 studies) and risk of T2DM. The pooled RRs were 0.94 (95% CI 0.91-0.97) and 0.88 (0.84-0.93) for 200 g/day total and low-fat dairy consumption, respectively. The pooled RRs were 0.80 (0.69-0.93) and 0.91 (0.82-1.00) for 30 g/d cheese and 50 g/d yogurt consumption, respectively. We also found a nonlinear association of total and low-fat dairy intake and T2DM risk, and the inverse association appeared to be strongest within 200 g/d intake. CONCLUSION: A modest increase in daily intake of dairy products such as low fat dairy, cheese and yogurt may contribute to the prevention of T2DM, which needs confirmation in randomized controlled trials. SN - 1932-6203 UR - https://www.unboundmedicine.com/medline/citation/24086304/Dairy_products_consumption_and_risk_of_type_2_diabetes:_systematic_review_and_dose_response_meta_analysis_ L2 - http://dx.plos.org/10.1371/journal.pone.0073965 DB - PRIME DP - Unbound Medicine ER -