Tags

Type your tag names separated by a space and hit enter

Association between Helicobacter pylori infection and pancreatic cancer development: a meta-analysis.
PLoS One. 2013; 8(9):e75559.Plos

Abstract

BACKGROUND

Pancreatic cancer is one of the most troublesome malignancies with dismal prognosis. H. pylori has been recognized as a type I carcinogen. Several studies have evaluated the association between H. pylori infection and pancreatic cancer development, however, the conclusions are inconsistent.

METHODS

Literature search was carried out in PubMed, EMBASE, Cochrane Library and CNKI databases to identify eligible researches. We performed overall meta-analysis of all studies included and subgroup analysis based on regional distribution. Quality of the studies (assessed by Newcastle-Ottawa quality assessment scale for case-control studies) and CagA+ strains of H. pylori were taken into consideration, and we conducted additional analyses including high-quality researches and those concerning CagA+ H. pylori respectively.

RESULTS

9 studies involving 3033 subjects (1083 pancreatic cancer cases, 1950 controls) were included. Summary OR and 95%CI of the overall meta-analysis of all included studies were 1.47 and 1.22-1.77, pooled data of the 4 high-quality studies were OR 1.28, 95%CI 1.01-1.63. OR of the 5 studies examined CagA+ strains was 1.42, corresponding 95%CI was 0.79 to 2.57. Summary estimates of subgroup analysis based on regional distribution are as follows, Europe group: OR 1.56, 95%CI 1.15-2.10; East Asia group: OR 2.01, 95%CI 1.33-3.02; North America group: OR 1.17, 95%CI 0.87-1.58. There was not obvious heterogeneity across the 9 studies. No publication bias was detected.

CONCLUSION

H. pylori infection is significantly, albeit weakly, associated with pancreatic cancer development. The association is prominent in Europe and East Asia, but not in North America. CagA+ H. pylori strains appear not to be associated with pancreatic cancer. However, more studies, especially prospective studies, are needed to validate our results.

Authors+Show Affiliations

Department of Hepatobiliary Surgery, Wuxi People's Hospital of Nanjing Medical University, Wuxi, Jiangsu Province, China ; Second Department of Hepatobiliary Surgery, Zhujiang Hospital of Southern Medical University, Guangzhou, Guangdong Province, China.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Meta-Analysis

Language

eng

PubMed ID

24086571

Citation

Xiao, Mingjia, et al. "Association Between Helicobacter Pylori Infection and Pancreatic Cancer Development: a Meta-analysis." PloS One, vol. 8, no. 9, 2013, pp. e75559.
Xiao M, Wang Y, Gao Y. Association between Helicobacter pylori infection and pancreatic cancer development: a meta-analysis. PLoS One. 2013;8(9):e75559.
Xiao, M., Wang, Y., & Gao, Y. (2013). Association between Helicobacter pylori infection and pancreatic cancer development: a meta-analysis. PloS One, 8(9), e75559. https://doi.org/10.1371/journal.pone.0075559
Xiao M, Wang Y, Gao Y. Association Between Helicobacter Pylori Infection and Pancreatic Cancer Development: a Meta-analysis. PLoS One. 2013;8(9):e75559. PubMed PMID: 24086571.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Association between Helicobacter pylori infection and pancreatic cancer development: a meta-analysis. AU - Xiao,Mingjia, AU - Wang,Yiming, AU - Gao,Yi, Y1 - 2013/09/26/ PY - 2013/06/07/received PY - 2013/08/14/accepted PY - 2013/10/3/entrez PY - 2013/10/3/pubmed PY - 2014/7/16/medline SP - e75559 EP - e75559 JF - PloS one JO - PLoS One VL - 8 IS - 9 N2 - BACKGROUND: Pancreatic cancer is one of the most troublesome malignancies with dismal prognosis. H. pylori has been recognized as a type I carcinogen. Several studies have evaluated the association between H. pylori infection and pancreatic cancer development, however, the conclusions are inconsistent. METHODS: Literature search was carried out in PubMed, EMBASE, Cochrane Library and CNKI databases to identify eligible researches. We performed overall meta-analysis of all studies included and subgroup analysis based on regional distribution. Quality of the studies (assessed by Newcastle-Ottawa quality assessment scale for case-control studies) and CagA+ strains of H. pylori were taken into consideration, and we conducted additional analyses including high-quality researches and those concerning CagA+ H. pylori respectively. RESULTS: 9 studies involving 3033 subjects (1083 pancreatic cancer cases, 1950 controls) were included. Summary OR and 95%CI of the overall meta-analysis of all included studies were 1.47 and 1.22-1.77, pooled data of the 4 high-quality studies were OR 1.28, 95%CI 1.01-1.63. OR of the 5 studies examined CagA+ strains was 1.42, corresponding 95%CI was 0.79 to 2.57. Summary estimates of subgroup analysis based on regional distribution are as follows, Europe group: OR 1.56, 95%CI 1.15-2.10; East Asia group: OR 2.01, 95%CI 1.33-3.02; North America group: OR 1.17, 95%CI 0.87-1.58. There was not obvious heterogeneity across the 9 studies. No publication bias was detected. CONCLUSION: H. pylori infection is significantly, albeit weakly, associated with pancreatic cancer development. The association is prominent in Europe and East Asia, but not in North America. CagA+ H. pylori strains appear not to be associated with pancreatic cancer. However, more studies, especially prospective studies, are needed to validate our results. SN - 1932-6203 UR - https://www.unboundmedicine.com/medline/citation/24086571/Association_between_Helicobacter_pylori_infection_and_pancreatic_cancer_development:_a_meta_analysis_ L2 - https://dx.plos.org/10.1371/journal.pone.0075559 DB - PRIME DP - Unbound Medicine ER -