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Dissolution enhancement of cefdinir with hydroxypropyl-β-cyclodextrin.
Drug Dev Ind Pharm. 2013 Nov; 39(11):1638-43.DD

Abstract

The solid state properties and dissolution behavior of binary systems of cefdinir (CEF) with hydroxypropyl-β-cyclodextrin (HP-β-CD) were investigated. CEF-HP-β-CD interaction in the solution state was studied by phase-solubility analysis and demonstrates the ability of HP-β-CD to complex with CEF giving A(L) type profile with 65.28 ± 1.3 M⁻¹ stability constant. The freeze drying technique was adopted to prepare binary systems of CEF with HP-β-CD in 1:1 molar ratio. The solid inclusion was characterized by fourier transform infrared spectroscopy (FTIR), differential scanning calorimetry (DSC), X-ray powder diffractometry (XRD), and scanning electron microscopy (SEM). Aqueous solubility of CEF-HP-β-CD inclusion complex was 2.36-fold of pure CEF. The dissolution profiles of inclusion complexes were determined and compared with those of CEF alone and their physical mixtures. The dissolution rate of inclusion complex was superior than the CEF alone. These approaches indicated that CEF was able to form an inclusion complex with HP-β-CD, and the inclusion compounds exhibited different spectroscopic features and properties.

Authors+Show Affiliations

School of pharmacy, Guangdong Pharmaceutical University , Guangzhou , PR China.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

24087855

Citation

Guo, Bohong, et al. "Dissolution Enhancement of Cefdinir With Hydroxypropyl-β-cyclodextrin." Drug Development and Industrial Pharmacy, vol. 39, no. 11, 2013, pp. 1638-43.
Guo B, Zhong S, Li N, et al. Dissolution enhancement of cefdinir with hydroxypropyl-β-cyclodextrin. Drug Dev Ind Pharm. 2013;39(11):1638-43.
Guo, B., Zhong, S., Li, N., Li, X., Yi, J., & Jin, M. (2013). Dissolution enhancement of cefdinir with hydroxypropyl-β-cyclodextrin. Drug Development and Industrial Pharmacy, 39(11), 1638-43. https://doi.org/10.3109/03639045.2012.728231
Guo B, et al. Dissolution Enhancement of Cefdinir With Hydroxypropyl-β-cyclodextrin. Drug Dev Ind Pharm. 2013;39(11):1638-43. PubMed PMID: 24087855.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Dissolution enhancement of cefdinir with hydroxypropyl-β-cyclodextrin. AU - Guo,Bohong, AU - Zhong,Shufen, AU - Li,Niying, AU - Li,Xiaofang, AU - Yi,Jun, AU - Jin,Miaozhen, PY - 2013/10/4/entrez PY - 2013/10/4/pubmed PY - 2014/5/16/medline SP - 1638 EP - 43 JF - Drug development and industrial pharmacy JO - Drug Dev Ind Pharm VL - 39 IS - 11 N2 - The solid state properties and dissolution behavior of binary systems of cefdinir (CEF) with hydroxypropyl-β-cyclodextrin (HP-β-CD) were investigated. CEF-HP-β-CD interaction in the solution state was studied by phase-solubility analysis and demonstrates the ability of HP-β-CD to complex with CEF giving A(L) type profile with 65.28 ± 1.3 M⁻¹ stability constant. The freeze drying technique was adopted to prepare binary systems of CEF with HP-β-CD in 1:1 molar ratio. The solid inclusion was characterized by fourier transform infrared spectroscopy (FTIR), differential scanning calorimetry (DSC), X-ray powder diffractometry (XRD), and scanning electron microscopy (SEM). Aqueous solubility of CEF-HP-β-CD inclusion complex was 2.36-fold of pure CEF. The dissolution profiles of inclusion complexes were determined and compared with those of CEF alone and their physical mixtures. The dissolution rate of inclusion complex was superior than the CEF alone. These approaches indicated that CEF was able to form an inclusion complex with HP-β-CD, and the inclusion compounds exhibited different spectroscopic features and properties. SN - 1520-5762 UR - https://www.unboundmedicine.com/medline/citation/24087855/Dissolution_enhancement_of_cefdinir_with_hydroxypropyl_β_cyclodextrin_ L2 - https://www.tandfonline.com/doi/full/10.3109/03639045.2012.728231 DB - PRIME DP - Unbound Medicine ER -