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Impact of botanical oils on polyunsaturated fatty acid metabolism and leukotriene generation in mild asthmatics.
Lipids Health Dis. 2013 Oct 02; 12:141.LH

Abstract

BACKGROUND

Dietary supplementation with botanical oils that contain n-6 and n-3 eighteen carbon chain (18C)-PUFA such as γ linolenic acid (GLA, 18:3n-6), stearidonic acid (SDA, 18:4n-3) and α linolenic acid (ALA, 18:3n-3) have been shown to impact PUFA metabolism, alter inflammatory processes including arachidonic acid (AA) metabolism and improve inflammatory disorders.

METHODS

The diet of mild asthmatics patients was supplemented for three weeks with varying doses of two botanical seed oils (borage oil [Borago officinalis, BO] and echium seed oil [Echium plantagineum; EO]) that contain SDA, ALA and GLA. A three week wash out period followed. The impact of these dietary manipulations was evaluated for several biochemical endpoints, including in vivo PUFA metabolism and ex vivo leukotriene generation from stimulated leukocytes.

RESULTS

Supplementation with several EO/BO combinations increased circulating 20-22 carbon (20-22C) PUFAs, including eicosapentaenoic acid (EPA), docosapentaenoic acid (DPA), and dihommo-gammalinolenic acid (DGLA), which have been shown to inhibit AA metabolism and inflammation without impacting circulating AA levels. BO/EO combinations also inhibited ex vivo leukotriene generation with some combinations attenuating cysteinyl leukotriene generation in stimulated basophils by >50% and in stimulated neutrophils by >35%.

CONCLUSIONS

This study shows that dietary supplementation with BO/EO alters 20-22C PUFA levels and attenuates leukotriene production in a manner consistent with a reduction in inflammation.

Authors+Show Affiliations

Department of Physiology/Pharmacology, Wake Forest School of Medicine, Medical Center Blvd, 27157, Winston-Salem, NC, USA. schilton@wakehealth.edu.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

24088297

Citation

Arm, Jonathan P., et al. "Impact of Botanical Oils On Polyunsaturated Fatty Acid Metabolism and Leukotriene Generation in Mild Asthmatics." Lipids in Health and Disease, vol. 12, 2013, p. 141.
Arm JP, Boyce JA, Wang L, et al. Impact of botanical oils on polyunsaturated fatty acid metabolism and leukotriene generation in mild asthmatics. Lipids Health Dis. 2013;12:141.
Arm, J. P., Boyce, J. A., Wang, L., Chhay, H., Zahid, M., Patil, V., Govindarajulu, U., Ivester, P., Weaver, K. L., Sergeant, S., Israel, E., & Chilton, F. H. (2013). Impact of botanical oils on polyunsaturated fatty acid metabolism and leukotriene generation in mild asthmatics. Lipids in Health and Disease, 12, 141. https://doi.org/10.1186/1476-511X-12-141
Arm JP, et al. Impact of Botanical Oils On Polyunsaturated Fatty Acid Metabolism and Leukotriene Generation in Mild Asthmatics. Lipids Health Dis. 2013 Oct 2;12:141. PubMed PMID: 24088297.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Impact of botanical oils on polyunsaturated fatty acid metabolism and leukotriene generation in mild asthmatics. AU - Arm,Jonathan P, AU - Boyce,Joshua A, AU - Wang,Lin, AU - Chhay,Heng, AU - Zahid,Muhammad, AU - Patil,Vaishali, AU - Govindarajulu,Usha, AU - Ivester,Priscilla, AU - Weaver,Kelly L, AU - Sergeant,Susan, AU - Israel,Elliot, AU - Chilton,Floyd H, Y1 - 2013/10/02/ PY - 2013/05/23/received PY - 2013/09/26/accepted PY - 2013/10/4/entrez PY - 2013/10/4/pubmed PY - 2014/7/9/medline SP - 141 EP - 141 JF - Lipids in health and disease JO - Lipids Health Dis VL - 12 N2 - BACKGROUND: Dietary supplementation with botanical oils that contain n-6 and n-3 eighteen carbon chain (18C)-PUFA such as γ linolenic acid (GLA, 18:3n-6), stearidonic acid (SDA, 18:4n-3) and α linolenic acid (ALA, 18:3n-3) have been shown to impact PUFA metabolism, alter inflammatory processes including arachidonic acid (AA) metabolism and improve inflammatory disorders. METHODS: The diet of mild asthmatics patients was supplemented for three weeks with varying doses of two botanical seed oils (borage oil [Borago officinalis, BO] and echium seed oil [Echium plantagineum; EO]) that contain SDA, ALA and GLA. A three week wash out period followed. The impact of these dietary manipulations was evaluated for several biochemical endpoints, including in vivo PUFA metabolism and ex vivo leukotriene generation from stimulated leukocytes. RESULTS: Supplementation with several EO/BO combinations increased circulating 20-22 carbon (20-22C) PUFAs, including eicosapentaenoic acid (EPA), docosapentaenoic acid (DPA), and dihommo-gammalinolenic acid (DGLA), which have been shown to inhibit AA metabolism and inflammation without impacting circulating AA levels. BO/EO combinations also inhibited ex vivo leukotriene generation with some combinations attenuating cysteinyl leukotriene generation in stimulated basophils by >50% and in stimulated neutrophils by >35%. CONCLUSIONS: This study shows that dietary supplementation with BO/EO alters 20-22C PUFA levels and attenuates leukotriene production in a manner consistent with a reduction in inflammation. SN - 1476-511X UR - https://www.unboundmedicine.com/medline/citation/24088297/Impact_of_botanical_oils_on_polyunsaturated_fatty_acid_metabolism_and_leukotriene_generation_in_mild_asthmatics_ L2 - https://lipidworld.biomedcentral.com/articles/10.1186/1476-511X-12-141 DB - PRIME DP - Unbound Medicine ER -