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[Medicinal chemistry and pharmacology focused on cannabidiol, a major component of the fiber-type cannabis].
Yakugaku Zasshi. 2013; 133(10):1093-101.YZ

Abstract

Considerable attention has focused on cannabidiol (CBD), a major non-psychotropic constituent of fiber-type cannabis plant, and it has been reported to possess diverse biological activities. Although CBD is obtained from non-enzymatic decarboxylation of its parent molecule, cannabidiolic acid (CBDA), several studies have investigated whether CBDA itself is biologically active. In the present report, the author summarizes findings indicating that; 1) CBDA is a selective cyclooxygenase-2 (COX-2) inhibitor, and ii) CBDA possesses an anti-migrative potential for highly invasive cancer cells, apparently through a mechanism involving inhibition of cAMP-dependent protein kinase A, coupled with an activation of the small GTPase, RhoA. Further, the author introduces recent findings on the medicinal chemistry and pharmacology of the CBD derivative, CBD-2',6'-dimethyl ether (CBDD), that exhibits inhibitory activity toward 15-lipoxygenase (15-LOX), an enzyme responsible for the production of oxidized low-density lipoprotein (LDL). These studies establish CBD as both an important experimental tool and as a lead compound for pharmaceutical development. In this review, the author further discusses the potential uses of CBD and its derivatives in future medicines.

Authors+Show Affiliations

Department of Molecular Biology, Daiichi University of Pharmacy.

Pub Type(s)

English Abstract
Journal Article
Research Support, Non-U.S. Gov't
Review

Language

jpn

PubMed ID

24088353

Citation

Takeda, Shuso. "[Medicinal Chemistry and Pharmacology Focused On Cannabidiol, a Major Component of the Fiber-type Cannabis]." Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan, vol. 133, no. 10, 2013, pp. 1093-101.
Takeda S. [Medicinal chemistry and pharmacology focused on cannabidiol, a major component of the fiber-type cannabis]. Yakugaku Zasshi. 2013;133(10):1093-101.
Takeda, S. (2013). [Medicinal chemistry and pharmacology focused on cannabidiol, a major component of the fiber-type cannabis]. Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan, 133(10), 1093-101.
Takeda S. [Medicinal Chemistry and Pharmacology Focused On Cannabidiol, a Major Component of the Fiber-type Cannabis]. Yakugaku Zasshi. 2013;133(10):1093-101. PubMed PMID: 24088353.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Medicinal chemistry and pharmacology focused on cannabidiol, a major component of the fiber-type cannabis]. A1 - Takeda,Shuso, PY - 2013/10/4/entrez PY - 2013/10/4/pubmed PY - 2014/4/26/medline SP - 1093 EP - 101 JF - Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan JO - Yakugaku Zasshi VL - 133 IS - 10 N2 - Considerable attention has focused on cannabidiol (CBD), a major non-psychotropic constituent of fiber-type cannabis plant, and it has been reported to possess diverse biological activities. Although CBD is obtained from non-enzymatic decarboxylation of its parent molecule, cannabidiolic acid (CBDA), several studies have investigated whether CBDA itself is biologically active. In the present report, the author summarizes findings indicating that; 1) CBDA is a selective cyclooxygenase-2 (COX-2) inhibitor, and ii) CBDA possesses an anti-migrative potential for highly invasive cancer cells, apparently through a mechanism involving inhibition of cAMP-dependent protein kinase A, coupled with an activation of the small GTPase, RhoA. Further, the author introduces recent findings on the medicinal chemistry and pharmacology of the CBD derivative, CBD-2',6'-dimethyl ether (CBDD), that exhibits inhibitory activity toward 15-lipoxygenase (15-LOX), an enzyme responsible for the production of oxidized low-density lipoprotein (LDL). These studies establish CBD as both an important experimental tool and as a lead compound for pharmaceutical development. In this review, the author further discusses the potential uses of CBD and its derivatives in future medicines. SN - 1347-5231 UR - https://www.unboundmedicine.com/medline/citation/24088353/[Medicinal_chemistry_and_pharmacology_focused_on_cannabidiol_a_major_component_of_the_fiber_type_cannabis]_ L2 - http://joi.jlc.jst.go.jp/DN/JST.JSTAGE/yakushi/13-00196?from=PubMed&lang=en DB - PRIME DP - Unbound Medicine ER -