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Usefulness of metabolic syndrome score in the prediction of angiographic coronary artery disease severity according to the presence of diabetes mellitus: relation with inflammatory markers and adipokines.
Cardiovasc Diabetol. 2013 Oct 02; 12:140.CD

Abstract

BACKGROUND

It is a matter of debate whether metabolic syndrome (MS) improves cardiovascular risk prediction beyond the risk associated with its individual components. The present study examined the association of MS score with high sensitivity C-reactive protein (hs-CRP), interleukin-6 (IL-6), resistin, adiponectin, and angiographic coronary artery disease (CAD) severity according to the presence of DM. In addition, the predictive value of various clinical and biochemical parameters were analyzed, including the MS score for angiographic CAD.

METHODS

The study enrolled 363 consecutive patients (196 men, 62 ± 11 years of age) who underwent coronary angiography for evaluation of chest pain. Blood samples were taken prior to elective coronary angiography. MS was defined by the National Cholesterol Education Program criteria, with MS score defined as the numbers of MS components. CAD was defined as > 50% luminal diameter stenosis of at least one major epicardial coronary artery. CAD severity was assessed using the Gensini score.

RESULTS

Of the 363 patients studied, 174 (48%) had CAD and 178 (49%) were diagnosed with MS. When the patients were divided into 4 subgroups according to MS score (0-1, 2, 3, 4-5), IL-6 levels and the CAD severity as assessed by the Gensini score increased as MS scores increased. In contrast, adiponectin levels decreased significantly as MS scores increased. When subjects were divided into two groups according to the presence of DM, the relationships between MS score and IL-6, adiponectin, and Gensini score were maintained only in patients without DM. Age, smoking, DM, MS score, and adiponectin independently predicted angiographic CAD in the whole population. However, age is the only predictor for angiographic CAD in patients with DM.

CONCLUSIONS

In the presence of DM, neither adipokines nor MS score predicted angiographic CAD. However, in non-diabetic patients, IL-6 and adiponectin showed progressive changes according to MS score, and MS score was an independent predictor of CAD in patients without DM.

Authors+Show Affiliations

Cardiology Division, Department of Internal Medicine, Gangnam Severance Hospital, Yonsei University College of Medicine, 211 Eonju-ro, Gangnam-gu, Seoul 135-720, Korea. cardioblues@yuhs.ac.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Evaluation Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

24088407

Citation

Kim, Jong-Youn, et al. "Usefulness of Metabolic Syndrome Score in the Prediction of Angiographic Coronary Artery Disease Severity According to the Presence of Diabetes Mellitus: Relation With Inflammatory Markers and Adipokines." Cardiovascular Diabetology, vol. 12, 2013, p. 140.
Kim JY, Choi EY, Mun HS, et al. Usefulness of metabolic syndrome score in the prediction of angiographic coronary artery disease severity according to the presence of diabetes mellitus: relation with inflammatory markers and adipokines. Cardiovasc Diabetol. 2013;12:140.
Kim, J. Y., Choi, E. Y., Mun, H. S., Min, P. K., Yoon, Y. W., Lee, B. K., Hong, B. K., Rim, S. J., & Kwon, H. M. (2013). Usefulness of metabolic syndrome score in the prediction of angiographic coronary artery disease severity according to the presence of diabetes mellitus: relation with inflammatory markers and adipokines. Cardiovascular Diabetology, 12, 140. https://doi.org/10.1186/1475-2840-12-140
Kim JY, et al. Usefulness of Metabolic Syndrome Score in the Prediction of Angiographic Coronary Artery Disease Severity According to the Presence of Diabetes Mellitus: Relation With Inflammatory Markers and Adipokines. Cardiovasc Diabetol. 2013 Oct 2;12:140. PubMed PMID: 24088407.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Usefulness of metabolic syndrome score in the prediction of angiographic coronary artery disease severity according to the presence of diabetes mellitus: relation with inflammatory markers and adipokines. AU - Kim,Jong-Youn, AU - Choi,Eui-Young, AU - Mun,Hee-Sun, AU - Min,Pil-Ki, AU - Yoon,Young-Won, AU - Lee,Byoung Kwon, AU - Hong,Bum-Kee, AU - Rim,Se-Joong, AU - Kwon,Hyuck Moon, Y1 - 2013/10/02/ PY - 2013/07/12/received PY - 2013/09/25/accepted PY - 2013/10/4/entrez PY - 2013/10/4/pubmed PY - 2014/5/8/medline SP - 140 EP - 140 JF - Cardiovascular diabetology JO - Cardiovasc Diabetol VL - 12 N2 - BACKGROUND: It is a matter of debate whether metabolic syndrome (MS) improves cardiovascular risk prediction beyond the risk associated with its individual components. The present study examined the association of MS score with high sensitivity C-reactive protein (hs-CRP), interleukin-6 (IL-6), resistin, adiponectin, and angiographic coronary artery disease (CAD) severity according to the presence of DM. In addition, the predictive value of various clinical and biochemical parameters were analyzed, including the MS score for angiographic CAD. METHODS: The study enrolled 363 consecutive patients (196 men, 62 ± 11 years of age) who underwent coronary angiography for evaluation of chest pain. Blood samples were taken prior to elective coronary angiography. MS was defined by the National Cholesterol Education Program criteria, with MS score defined as the numbers of MS components. CAD was defined as > 50% luminal diameter stenosis of at least one major epicardial coronary artery. CAD severity was assessed using the Gensini score. RESULTS: Of the 363 patients studied, 174 (48%) had CAD and 178 (49%) were diagnosed with MS. When the patients were divided into 4 subgroups according to MS score (0-1, 2, 3, 4-5), IL-6 levels and the CAD severity as assessed by the Gensini score increased as MS scores increased. In contrast, adiponectin levels decreased significantly as MS scores increased. When subjects were divided into two groups according to the presence of DM, the relationships between MS score and IL-6, adiponectin, and Gensini score were maintained only in patients without DM. Age, smoking, DM, MS score, and adiponectin independently predicted angiographic CAD in the whole population. However, age is the only predictor for angiographic CAD in patients with DM. CONCLUSIONS: In the presence of DM, neither adipokines nor MS score predicted angiographic CAD. However, in non-diabetic patients, IL-6 and adiponectin showed progressive changes according to MS score, and MS score was an independent predictor of CAD in patients without DM. SN - 1475-2840 UR - https://www.unboundmedicine.com/medline/citation/24088407/Usefulness_of_metabolic_syndrome_score_in_the_prediction_of_angiographic_coronary_artery_disease_severity_according_to_the_presence_of_diabetes_mellitus:_relation_with_inflammatory_markers_and_adipokines_ L2 - https://cardiab.biomedcentral.com/articles/10.1186/1475-2840-12-140 DB - PRIME DP - Unbound Medicine ER -