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The burden of chronic hepatitis B virus infection in Australia, 2011.
Aust N Z J Public Health. 2013 Oct; 37(5):416-22.AN

Abstract

OBJECTIVE

The number of Australians living with chronic hepatitis B (CHB) is thought to be increasing, as are adverse outcomes including cirrhosis and liver cancer, however, robust, up-to-date estimates of this burden are limited. Contemporary estimates of the prevalence of CHB in Australia are essential to guide appropriate public health and clinical responses.

METHODS

This study used census-based methodology attributing risk of CHB by country of birth and Aboriginal and Torres Strait Islander status, augmented with priority risk-group based estimates. Deterministic mathematical modelling was used for comparison and for validation of census-derived estimates.

RESULTS

An estimated 218,000 Australians (plausible range 192,000-284,000) are living with CHB, a significant increase over previous estimates. The prevalence derived using mathematical modelling was similar, at 204,000. Notable differences were observed by geographic area in both prevalence and the populations predominantly affected. It is estimated that only 56% of people living with CHB in Australia have been diagnosed and notified.

CONCLUSIONS

The prevalence of CHB in Australia is increasing, with 1% of the population now estimated to be affected. The majority of the burden is experienced by people born overseas in endemic areas, with more than 95% of new cases of CHB entering the population through migration.

IMPLICATIONS

It is imperative that more attention and greater resources are devoted to addressing CHB in Australia; to increase the proportion of Australians affected who have been diagnosed and who are on treatment, in accordance with the First National Hepatitis B Strategy.

Authors+Show Affiliations

Epidemiology Unit, WHO Regional Reference Laboratory for Hepatitis B, Victorian Infectious Diseases Reference Laboratory; University of Melbourne, Victoria National Policy and Education Division, Australasian Society for HIV Medicine, New South Wales Epidemiology Unit, WHO Regional Reference Laboratory for Hepatitis B, Victorian Infectious Diseases Reference Laboratory; University of Melbourne, Victoria.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

24090323

Citation

MacLachlan, Jennifer H., et al. "The Burden of Chronic Hepatitis B Virus Infection in Australia, 2011." Australian and New Zealand Journal of Public Health, vol. 37, no. 5, 2013, pp. 416-22.
MacLachlan JH, Allard N, Towell V, et al. The burden of chronic hepatitis B virus infection in Australia, 2011. Aust N Z J Public Health. 2013;37(5):416-22.
MacLachlan, J. H., Allard, N., Towell, V., & Cowie, B. C. (2013). The burden of chronic hepatitis B virus infection in Australia, 2011. Australian and New Zealand Journal of Public Health, 37(5), 416-22. https://doi.org/10.1111/1753-6405.12049
MacLachlan JH, et al. The Burden of Chronic Hepatitis B Virus Infection in Australia, 2011. Aust N Z J Public Health. 2013;37(5):416-22. PubMed PMID: 24090323.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The burden of chronic hepatitis B virus infection in Australia, 2011. AU - MacLachlan,Jennifer H, AU - Allard,Nicole, AU - Towell,Vanessa, AU - Cowie,Benjamin C, Y1 - 2013/03/20/ PY - 2013/10/5/entrez PY - 2013/10/5/pubmed PY - 2014/3/19/medline KW - epidemiology KW - hepatitis B KW - liver cancer KW - public health KW - viral hepatitis SP - 416 EP - 22 JF - Australian and New Zealand journal of public health JO - Aust N Z J Public Health VL - 37 IS - 5 N2 - OBJECTIVE: The number of Australians living with chronic hepatitis B (CHB) is thought to be increasing, as are adverse outcomes including cirrhosis and liver cancer, however, robust, up-to-date estimates of this burden are limited. Contemporary estimates of the prevalence of CHB in Australia are essential to guide appropriate public health and clinical responses. METHODS: This study used census-based methodology attributing risk of CHB by country of birth and Aboriginal and Torres Strait Islander status, augmented with priority risk-group based estimates. Deterministic mathematical modelling was used for comparison and for validation of census-derived estimates. RESULTS: An estimated 218,000 Australians (plausible range 192,000-284,000) are living with CHB, a significant increase over previous estimates. The prevalence derived using mathematical modelling was similar, at 204,000. Notable differences were observed by geographic area in both prevalence and the populations predominantly affected. It is estimated that only 56% of people living with CHB in Australia have been diagnosed and notified. CONCLUSIONS: The prevalence of CHB in Australia is increasing, with 1% of the population now estimated to be affected. The majority of the burden is experienced by people born overseas in endemic areas, with more than 95% of new cases of CHB entering the population through migration. IMPLICATIONS: It is imperative that more attention and greater resources are devoted to addressing CHB in Australia; to increase the proportion of Australians affected who have been diagnosed and who are on treatment, in accordance with the First National Hepatitis B Strategy. SN - 1753-6405 UR - https://www.unboundmedicine.com/medline/citation/24090323/The_burden_of_chronic_hepatitis_B_virus_infection_in_Australia_2011_ L2 - https://doi.org/10.1111/1753-6405.12049 DB - PRIME DP - Unbound Medicine ER -