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Fruit and vegetable intake and breast cancer risk defined by estrogen and progesterone receptor status: the Japan Public Health Center-based Prospective Study.
Cancer Causes Control 2013; 24(12):2117-28CC

Abstract

BACKGROUND

Epidemiological evidence for the impact of fruit and vegetable intake on breast cancer risk among the Japanese populations is scarce.

OBJECTIVE

The purpose of this study was to evaluate the association between fruit and vegetable intake and breast cancer risk among 47,289 Japanese women.

DESIGN

The study was conducted under a population-based prospective cohort design. Dietary assessment was performed using a validated food frequency questionnaire. A Cox proportional hazards regression model was used to calculate relative risks (RRs) and their corresponding 95 % confidence intervals (CIs).

RESULTS

During an average of 10.2 years of follow-up, 452 cases of breast cancer were newly diagnosed. No association with breast cancer risk was seen for intake of total fruits and vegetables, cruciferous vegetables, green-leaf vegetables, yellow vegetables, or tomato products in overall or postmenopausal women. Cruciferous vegetable intake was associated with a statistically significant decrease in risk of premenopausal breast cancer [multivariable-RRQ4 vs. Q1 = 0.64 (95 % CI = 0.38-1.10; p trend = .046)] and showed a marginally inverse association with ER+ PR+ tumors [RRper 100 g increment = 0.64 (95 % CI = 0.41-1.00)]. In contrast, positive associations were seen between intake of total fruits and citrus fruits and breast cancer risk in overall and premenopausal women. However, these associations for fruit were all attenuated with additional adjustment for vitamin C intake.

CONCLUSIONS

Our results suggest an overall null association between total fruit and vegetable intake and breast cancer risk. Intake of cruciferous vegetable showed a statistically significant association with a decreased risk of breast cancer among premenopausal women.

Authors+Show Affiliations

Division of Medical Nutrition, Department of Medical Healthcare, Tokyo Healthcare University, 3-11-3 Setagaya, Setagaya-ku, Tokyo, Japan, r-suzuki@thcu.ac.jp.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

24091793

Citation

Suzuki, Reiko, et al. "Fruit and Vegetable Intake and Breast Cancer Risk Defined By Estrogen and Progesterone Receptor Status: the Japan Public Health Center-based Prospective Study." Cancer Causes & Control : CCC, vol. 24, no. 12, 2013, pp. 2117-28.
Suzuki R, Iwasaki M, Hara A, et al. Fruit and vegetable intake and breast cancer risk defined by estrogen and progesterone receptor status: the Japan Public Health Center-based Prospective Study. Cancer Causes Control. 2013;24(12):2117-28.
Suzuki, R., Iwasaki, M., Hara, A., Inoue, M., Sasazuki, S., Sawada, N., ... Tsugane, S. (2013). Fruit and vegetable intake and breast cancer risk defined by estrogen and progesterone receptor status: the Japan Public Health Center-based Prospective Study. Cancer Causes & Control : CCC, 24(12), pp. 2117-28. doi:10.1007/s10552-013-0289-7.
Suzuki R, et al. Fruit and Vegetable Intake and Breast Cancer Risk Defined By Estrogen and Progesterone Receptor Status: the Japan Public Health Center-based Prospective Study. Cancer Causes Control. 2013;24(12):2117-28. PubMed PMID: 24091793.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Fruit and vegetable intake and breast cancer risk defined by estrogen and progesterone receptor status: the Japan Public Health Center-based Prospective Study. AU - Suzuki,Reiko, AU - Iwasaki,Motoki, AU - Hara,Azusa, AU - Inoue,Manami, AU - Sasazuki,Shizuka, AU - Sawada,Norie, AU - Yamaji,Taiki, AU - Shimazu,Taichi, AU - Tsugane,Shoichiro, AU - ,, Y1 - 2013/10/04/ PY - 2013/05/13/received PY - 2013/09/11/accepted PY - 2013/10/5/entrez PY - 2013/10/5/pubmed PY - 2014/6/20/medline SP - 2117 EP - 28 JF - Cancer causes & control : CCC JO - Cancer Causes Control VL - 24 IS - 12 N2 - BACKGROUND: Epidemiological evidence for the impact of fruit and vegetable intake on breast cancer risk among the Japanese populations is scarce. OBJECTIVE: The purpose of this study was to evaluate the association between fruit and vegetable intake and breast cancer risk among 47,289 Japanese women. DESIGN: The study was conducted under a population-based prospective cohort design. Dietary assessment was performed using a validated food frequency questionnaire. A Cox proportional hazards regression model was used to calculate relative risks (RRs) and their corresponding 95 % confidence intervals (CIs). RESULTS: During an average of 10.2 years of follow-up, 452 cases of breast cancer were newly diagnosed. No association with breast cancer risk was seen for intake of total fruits and vegetables, cruciferous vegetables, green-leaf vegetables, yellow vegetables, or tomato products in overall or postmenopausal women. Cruciferous vegetable intake was associated with a statistically significant decrease in risk of premenopausal breast cancer [multivariable-RRQ4 vs. Q1 = 0.64 (95 % CI = 0.38-1.10; p trend = .046)] and showed a marginally inverse association with ER+ PR+ tumors [RRper 100 g increment = 0.64 (95 % CI = 0.41-1.00)]. In contrast, positive associations were seen between intake of total fruits and citrus fruits and breast cancer risk in overall and premenopausal women. However, these associations for fruit were all attenuated with additional adjustment for vitamin C intake. CONCLUSIONS: Our results suggest an overall null association between total fruit and vegetable intake and breast cancer risk. Intake of cruciferous vegetable showed a statistically significant association with a decreased risk of breast cancer among premenopausal women. SN - 1573-7225 UR - https://www.unboundmedicine.com/medline/citation/24091793/Fruit_and_vegetable_intake_and_breast_cancer_risk_defined_by_estrogen_and_progesterone_receptor_status:_the_Japan_Public_Health_Center_based_Prospective_Study_ L2 - https://doi.org/10.1007/s10552-013-0289-7 DB - PRIME DP - Unbound Medicine ER -