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Change in heart rate variability precedes the occurrence of periodic leg movements during sleep: an observational study.
BMC Neurol. 2013 Oct 06; 13:139.BN

Abstract

BACKGROUND

Several reports have described that individual periodic leg movements during sleep (PLMS) activities are associated with autonomic nervous system activity occurring shortly before each PLMS activity. Nevertheless, no study has investigated dynamic changes of autonomic nervous system activity before the onset of PLMS. This study detected changes in heart rate variability (HRV) at the onset of the period with PLMS using complex demodulation method.

METHODS

This study enrolled 14 patients diagnosed as having idiopathic PLMS disorder (PLMD). In periods with and without PLMS during sleep stage 2, HRV-related variables and the spectral power of fluctuation of a high frequency (HF) band (FHFB) were analyzed and compared. The changes of those parameters during transition from the period without PLMS to that with PLMS were explored.

RESULTS

Spectral power in the low frequency (LF) band and very low frequency (VLF) band were higher in the period with PLMS. Additionally, the average frequency in FHFB was higher. The frequency in this band fluctuated during the period with PLMS with remarkable elevation of FHFB. Moreover, spectral powers in FHFB, LF, and VLF were remarkably elevated shortly before the beginning of the period with PLMS (FHFB, -65 s; LF, -53 s; and VLF, -45 s).

CONCLUSIONS

Elevation of sympathetic nervous system activity and mean frequency fluctuation in an HF band can occur several tens of seconds before the period with PLMS. Dynamic changes in the autonomic nervous system activity might be related to the vulnerability to PLMS occurrence during the night.

Authors+Show Affiliations

Department of Somnology, Tokyo Medical University, 1-24-6, Yoyogi, Shibuya-ku Tokyo, Japan. taeko_ssi@yahoo.co.jp.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

24093585

Citation

Sasai, Taeko, et al. "Change in Heart Rate Variability Precedes the Occurrence of Periodic Leg Movements During Sleep: an Observational Study." BMC Neurology, vol. 13, 2013, p. 139.
Sasai T, Matsuura M, Inoue Y. Change in heart rate variability precedes the occurrence of periodic leg movements during sleep: an observational study. BMC Neurol. 2013;13:139.
Sasai, T., Matsuura, M., & Inoue, Y. (2013). Change in heart rate variability precedes the occurrence of periodic leg movements during sleep: an observational study. BMC Neurology, 13, 139. https://doi.org/10.1186/1471-2377-13-139
Sasai T, Matsuura M, Inoue Y. Change in Heart Rate Variability Precedes the Occurrence of Periodic Leg Movements During Sleep: an Observational Study. BMC Neurol. 2013 Oct 6;13:139. PubMed PMID: 24093585.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Change in heart rate variability precedes the occurrence of periodic leg movements during sleep: an observational study. AU - Sasai,Taeko, AU - Matsuura,Masato, AU - Inoue,Yuichi, Y1 - 2013/10/06/ PY - 2013/06/12/received PY - 2013/09/18/accepted PY - 2013/10/8/entrez PY - 2013/10/8/pubmed PY - 2014/4/5/medline SP - 139 EP - 139 JF - BMC neurology JO - BMC Neurol VL - 13 N2 - BACKGROUND: Several reports have described that individual periodic leg movements during sleep (PLMS) activities are associated with autonomic nervous system activity occurring shortly before each PLMS activity. Nevertheless, no study has investigated dynamic changes of autonomic nervous system activity before the onset of PLMS. This study detected changes in heart rate variability (HRV) at the onset of the period with PLMS using complex demodulation method. METHODS: This study enrolled 14 patients diagnosed as having idiopathic PLMS disorder (PLMD). In periods with and without PLMS during sleep stage 2, HRV-related variables and the spectral power of fluctuation of a high frequency (HF) band (FHFB) were analyzed and compared. The changes of those parameters during transition from the period without PLMS to that with PLMS were explored. RESULTS: Spectral power in the low frequency (LF) band and very low frequency (VLF) band were higher in the period with PLMS. Additionally, the average frequency in FHFB was higher. The frequency in this band fluctuated during the period with PLMS with remarkable elevation of FHFB. Moreover, spectral powers in FHFB, LF, and VLF were remarkably elevated shortly before the beginning of the period with PLMS (FHFB, -65 s; LF, -53 s; and VLF, -45 s). CONCLUSIONS: Elevation of sympathetic nervous system activity and mean frequency fluctuation in an HF band can occur several tens of seconds before the period with PLMS. Dynamic changes in the autonomic nervous system activity might be related to the vulnerability to PLMS occurrence during the night. SN - 1471-2377 UR - https://www.unboundmedicine.com/medline/citation/24093585/Change_in_heart_rate_variability_precedes_the_occurrence_of_periodic_leg_movements_during_sleep:_an_observational_study_ L2 - https://bmcneurol.biomedcentral.com/articles/10.1186/1471-2377-13-139 DB - PRIME DP - Unbound Medicine ER -