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Fabrication of novel nanofiber scaffolds from gum tragacanth/poly(vinyl alcohol) for wound dressing application: in vitro evaluation and antibacterial properties.
Mater Sci Eng C Mater Biol Appl 2013; 33(8):4935-43MS

Abstract

Gum tragacanth (GT) is one of the most widely used natural gums which has found applications in many areas because of its attractive features such as biodegradability, nontoxic nature, natural availability, higher resistance to microbial attacks and long shelf-life properties. GT and poly(vinyl alcohol) (PVA) were dissolved in deionized water in different ratios i.e., 0/100, 30/70, 60/40, 50/50, 40/60, 70/30, 0/100 mass ratio of GT/PVA. Nanofibers were produced from these solutions using electrospinning technique. The effect of different electrospinning parameters such as extrusion rate of polymer solutions, solution concentration, electrode spacing distance and applied voltage on the morphology of nanofibers was examined. The antibacterial activity of nanofibers and GT solution against Staphylococcus aureus and Pseudomonas aeruginosa was examined and these nanofibers showed good antibacterial property against Gram-negative bacteria. FTIR data showed that these two polymers may be having hydrogen bonding interactions. DSC data revealed that the exothermic peak at about 194°C for PVA shifted to a lower temperature in GT/PVA blend. Human fibroblast cells adhered and proliferated well on the GT/PVA nanofiber scaffolds. MTT assay was carried out on the GT/PVA nanofiber to investigate the proliferation rate of fibroblast cells on the scaffolds.

Authors+Show Affiliations

Textile Engineering Department, Amirkabir University of Technology, Tehran, Iran.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

24094207

Citation

Ranjbar-Mohammadi, Marziyeh, et al. "Fabrication of Novel Nanofiber Scaffolds From Gum Tragacanth/poly(vinyl Alcohol) for Wound Dressing Application: in Vitro Evaluation and Antibacterial Properties." Materials Science & Engineering. C, Materials for Biological Applications, vol. 33, no. 8, 2013, pp. 4935-43.
Ranjbar-Mohammadi M, Bahrami SH, Joghataei MT. Fabrication of novel nanofiber scaffolds from gum tragacanth/poly(vinyl alcohol) for wound dressing application: in vitro evaluation and antibacterial properties. Mater Sci Eng C Mater Biol Appl. 2013;33(8):4935-43.
Ranjbar-Mohammadi, M., Bahrami, S. H., & Joghataei, M. T. (2013). Fabrication of novel nanofiber scaffolds from gum tragacanth/poly(vinyl alcohol) for wound dressing application: in vitro evaluation and antibacterial properties. Materials Science & Engineering. C, Materials for Biological Applications, 33(8), pp. 4935-43. doi:10.1016/j.msec.2013.08.016.
Ranjbar-Mohammadi M, Bahrami SH, Joghataei MT. Fabrication of Novel Nanofiber Scaffolds From Gum Tragacanth/poly(vinyl Alcohol) for Wound Dressing Application: in Vitro Evaluation and Antibacterial Properties. Mater Sci Eng C Mater Biol Appl. 2013 Dec 1;33(8):4935-43. PubMed PMID: 24094207.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Fabrication of novel nanofiber scaffolds from gum tragacanth/poly(vinyl alcohol) for wound dressing application: in vitro evaluation and antibacterial properties. AU - Ranjbar-Mohammadi,Marziyeh, AU - Bahrami,S Hajir, AU - Joghataei,M T, Y1 - 2013/08/28/ PY - 2013/04/21/received PY - 2013/07/01/revised PY - 2013/08/13/accepted PY - 2013/10/8/entrez PY - 2013/10/8/pubmed PY - 2014/5/7/medline KW - Antibacterial KW - Electrospinning KW - Gum tragacanth KW - Nanofiber SP - 4935 EP - 43 JF - Materials science & engineering. C, Materials for biological applications JO - Mater Sci Eng C Mater Biol Appl VL - 33 IS - 8 N2 - Gum tragacanth (GT) is one of the most widely used natural gums which has found applications in many areas because of its attractive features such as biodegradability, nontoxic nature, natural availability, higher resistance to microbial attacks and long shelf-life properties. GT and poly(vinyl alcohol) (PVA) were dissolved in deionized water in different ratios i.e., 0/100, 30/70, 60/40, 50/50, 40/60, 70/30, 0/100 mass ratio of GT/PVA. Nanofibers were produced from these solutions using electrospinning technique. The effect of different electrospinning parameters such as extrusion rate of polymer solutions, solution concentration, electrode spacing distance and applied voltage on the morphology of nanofibers was examined. The antibacterial activity of nanofibers and GT solution against Staphylococcus aureus and Pseudomonas aeruginosa was examined and these nanofibers showed good antibacterial property against Gram-negative bacteria. FTIR data showed that these two polymers may be having hydrogen bonding interactions. DSC data revealed that the exothermic peak at about 194°C for PVA shifted to a lower temperature in GT/PVA blend. Human fibroblast cells adhered and proliferated well on the GT/PVA nanofiber scaffolds. MTT assay was carried out on the GT/PVA nanofiber to investigate the proliferation rate of fibroblast cells on the scaffolds. SN - 1873-0191 UR - https://www.unboundmedicine.com/medline/citation/24094207/Fabrication_of_novel_nanofiber_scaffolds_from_gum_tragacanth/poly_vinyl_alcohol__for_wound_dressing_application:_in_vitro_evaluation_and_antibacterial_properties_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0928-4931(13)00479-7 DB - PRIME DP - Unbound Medicine ER -