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Maternal fat intake during pregnancy and wheeze and eczema in Japanese infants: the Kyushu Okinawa Maternal and Child Health Study.
Ann Epidemiol. 2013 Nov; 23(11):674-80.AE

Abstract

PURPOSE

This cohort study examined the relationship between maternal intake of individual fatty acids, meat, and fish during pregnancy and the risk of wheeze and eczema in children aged 23-29 months because epidemiologic evidence on this topic is inconclusive.

METHODS

Subjects were 1354 Japanese mother-child pairs. Data on maternal intake during pregnancy were assessed with a validated diet history questionnaire. Data on symptoms of wheeze and eczema were based on criteria of the International Study of Asthma and Allergies in Childhood.

RESULTS

Significant inverse exposure-response relationships were observed between maternal intake of eicosapentaenoic acid (EPA) and EPA plus docosahexaenoic acid (DHA) during pregnancy and infantile wheeze although the adjusted odds ratios between extreme quartiles fell just short of the significance level. No such inverse relationships were detected for infantile eczema. Maternal intake of total fat, saturated fatty acids, monounsaturated fatty acids, total n-3 polyunsaturated fatty acids (PUFA), α-linolenic acid, DHA, total n-6 PUFA, linoleic acid, arachidonic acid, cholesterol, fish, and meat and the ratio of n-3 to n-6 PUFA consumption were not significantly related to infantile wheeze or eczema.

CONCLUSIONS

Higher maternal intake of EPA and EPA plus DHA during pregnancy may reduce the risk of infantile wheeze.

Authors+Show Affiliations

Department of Preventive Medicine and Public Health, Faculty of Medicine, Fukuoka University, Fukuoka, Japan. Electronic address: miyake-y@fukuoka-u.ac.jp.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

24094480

Citation

Miyake, Yoshihiro, et al. "Maternal Fat Intake During Pregnancy and Wheeze and Eczema in Japanese Infants: the Kyushu Okinawa Maternal and Child Health Study." Annals of Epidemiology, vol. 23, no. 11, 2013, pp. 674-80.
Miyake Y, Tanaka K, Okubo H, et al. Maternal fat intake during pregnancy and wheeze and eczema in Japanese infants: the Kyushu Okinawa Maternal and Child Health Study. Ann Epidemiol. 2013;23(11):674-80.
Miyake, Y., Tanaka, K., Okubo, H., Sasaki, S., & Arakawa, M. (2013). Maternal fat intake during pregnancy and wheeze and eczema in Japanese infants: the Kyushu Okinawa Maternal and Child Health Study. Annals of Epidemiology, 23(11), 674-80. https://doi.org/10.1016/j.annepidem.2013.08.004
Miyake Y, et al. Maternal Fat Intake During Pregnancy and Wheeze and Eczema in Japanese Infants: the Kyushu Okinawa Maternal and Child Health Study. Ann Epidemiol. 2013;23(11):674-80. PubMed PMID: 24094480.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Maternal fat intake during pregnancy and wheeze and eczema in Japanese infants: the Kyushu Okinawa Maternal and Child Health Study. AU - Miyake,Yoshihiro, AU - Tanaka,Keiko, AU - Okubo,Hitomi, AU - Sasaki,Satoshi, AU - Arakawa,Masashi, Y1 - 2013/10/02/ PY - 2013/05/09/received PY - 2013/08/05/revised PY - 2013/08/26/accepted PY - 2013/10/8/entrez PY - 2013/10/8/pubmed PY - 2013/12/24/medline KW - Docosahexaenoic acid KW - Eczema KW - Eicosapentaenoic acid KW - Intake KW - Japanese KW - Pregnancy KW - Wheezing SP - 674 EP - 80 JF - Annals of epidemiology JO - Ann Epidemiol VL - 23 IS - 11 N2 - PURPOSE: This cohort study examined the relationship between maternal intake of individual fatty acids, meat, and fish during pregnancy and the risk of wheeze and eczema in children aged 23-29 months because epidemiologic evidence on this topic is inconclusive. METHODS: Subjects were 1354 Japanese mother-child pairs. Data on maternal intake during pregnancy were assessed with a validated diet history questionnaire. Data on symptoms of wheeze and eczema were based on criteria of the International Study of Asthma and Allergies in Childhood. RESULTS: Significant inverse exposure-response relationships were observed between maternal intake of eicosapentaenoic acid (EPA) and EPA plus docosahexaenoic acid (DHA) during pregnancy and infantile wheeze although the adjusted odds ratios between extreme quartiles fell just short of the significance level. No such inverse relationships were detected for infantile eczema. Maternal intake of total fat, saturated fatty acids, monounsaturated fatty acids, total n-3 polyunsaturated fatty acids (PUFA), α-linolenic acid, DHA, total n-6 PUFA, linoleic acid, arachidonic acid, cholesterol, fish, and meat and the ratio of n-3 to n-6 PUFA consumption were not significantly related to infantile wheeze or eczema. CONCLUSIONS: Higher maternal intake of EPA and EPA plus DHA during pregnancy may reduce the risk of infantile wheeze. SN - 1873-2585 UR - https://www.unboundmedicine.com/medline/citation/24094480/Maternal_fat_intake_during_pregnancy_and_wheeze_and_eczema_in_Japanese_infants:_the_Kyushu_Okinawa_Maternal_and_Child_Health_Study_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1047-2797(13)00344-X DB - PRIME DP - Unbound Medicine ER -