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Inverse association between circulating vitamin D and mortality--dependent on sex and cause of death?
Nutr Metab Cardiovasc Dis. 2013 Oct; 23(10):960-6.NM

Abstract

BACKGROUND AND AIMS

In various populations, vitamin D deficiency is associated with chronic diseases and mortality. We examined the association between concentration of circulating 25-hydroxyvitamin D [25(OH)D], a marker of vitamin D status, and all-cause as well as cause-specific mortality.

METHODS AND RESULTS

The study included 3404 participants of the general adult Swiss population, who were recruited between November 1988 and June 1989 and followed-up until the end of 2008. Circulating 25(OH)D was measured by protein-bound assay. Cox proportional hazards regression was used to examine the association between 25(OH)D concentration and all-cause and cause-specific mortality adjusting for sex, age, season, diet, nationality, blood pressure, and smoking status. Per 10 ng/mL increase in 25(OH)D concentration, all-cause mortality decreased by 20% (HR = 0.83; 95% CI 0.74-0.92). 25(OH)D concentration was inversely associated with cardiovascular mortality in women (HR = 0.68, 95% CI 0.46-1.00 per 10 ng/mL increase), but not in men (HR = 0.97; 95% CI 0.77-1.23). In contrast, 25(OH)D concentration was inversely associated with cancer mortality in men (HR = 0.72, 95% CI 0.57-0.91 per 10 ng/mL increase), but not in women (HR = 1.14, 95% CI 0.93-1.39). Multivariate adjustment only slightly modified the 25(OH)D-mortality association.

CONCLUSION

25(OH)D was similarly inversely related to all-cause mortality in men and women. However, we observed opposite effects in women and men with respect to cardiovascular and cancer mortality.

Links

Publisher Full Text (DOI)

Authors+Show Affiliations

Rohrmann S
Division of Cancer Epidemiology and Prevention, Institute of Social and Preventive Medicine, University of Zurich, Zurich, Switzerland; Unit of Demography and Health Statistics, Institute of Social and Preventive Medicine, University of Zurich, Zurich, Switzerland. Electronic address: sabine.rohrmann@ifspm.uzh.ch.
Braun J
No affiliation info available
Bopp M
No affiliation info available
Faeh D
No affiliation info available
Swiss National Cohort (SNC)
No affiliation info available

MeSH

25-Hydroxyvitamin D 2AdultAgedAgingCalcifediolCardiovascular DiseasesCohort StudiesFemaleFollow-Up StudiesHumansLongitudinal StudiesMaleMiddle AgedMortalityNeoplasmsProportional Hazards ModelsRisk FactorsSex CharacteristicsSwitzerlandVitamin D Deficiency

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

24095147

Citation

Rohrmann, S, et al. "Inverse Association Between Circulating Vitamin D and Mortality--dependent On Sex and Cause of Death?" Nutrition, Metabolism, and Cardiovascular Diseases : NMCD, vol. 23, no. 10, 2013, pp. 960-6.
Rohrmann S, Braun J, Bopp M, et al. Inverse association between circulating vitamin D and mortality--dependent on sex and cause of death? Nutr Metab Cardiovasc Dis. 2013;23(10):960-6.
Rohrmann, S., Braun, J., Bopp, M., & Faeh, D. (2013). Inverse association between circulating vitamin D and mortality--dependent on sex and cause of death? Nutrition, Metabolism, and Cardiovascular Diseases : NMCD, 23(10), 960-6. https://doi.org/10.1016/j.numecd.2013.05.005
Rohrmann S, et al. Inverse Association Between Circulating Vitamin D and Mortality--dependent On Sex and Cause of Death. Nutr Metab Cardiovasc Dis. 2013;23(10):960-6. PubMed PMID: 24095147.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Inverse association between circulating vitamin D and mortality--dependent on sex and cause of death? AU - Rohrmann,S, AU - Braun,J, AU - Bopp,M, AU - Faeh,D, AU - ,, Y1 - 2013/10/03/ PY - 2012/12/10/received PY - 2013/05/02/revised PY - 2013/05/25/accepted PY - 2013/10/8/entrez PY - 2013/10/8/pubmed PY - 2014/6/18/medline KW - MONICA KW - Mortality KW - Switzerland KW - Vitamin D SP - 960 EP - 6 JF - Nutrition, metabolism, and cardiovascular diseases : NMCD JO - Nutr Metab Cardiovasc Dis VL - 23 IS - 10 N2 - BACKGROUND AND AIMS: In various populations, vitamin D deficiency is associated with chronic diseases and mortality. We examined the association between concentration of circulating 25-hydroxyvitamin D [25(OH)D], a marker of vitamin D status, and all-cause as well as cause-specific mortality. METHODS AND RESULTS: The study included 3404 participants of the general adult Swiss population, who were recruited between November 1988 and June 1989 and followed-up until the end of 2008. Circulating 25(OH)D was measured by protein-bound assay. Cox proportional hazards regression was used to examine the association between 25(OH)D concentration and all-cause and cause-specific mortality adjusting for sex, age, season, diet, nationality, blood pressure, and smoking status. Per 10 ng/mL increase in 25(OH)D concentration, all-cause mortality decreased by 20% (HR = 0.83; 95% CI 0.74-0.92). 25(OH)D concentration was inversely associated with cardiovascular mortality in women (HR = 0.68, 95% CI 0.46-1.00 per 10 ng/mL increase), but not in men (HR = 0.97; 95% CI 0.77-1.23). In contrast, 25(OH)D concentration was inversely associated with cancer mortality in men (HR = 0.72, 95% CI 0.57-0.91 per 10 ng/mL increase), but not in women (HR = 1.14, 95% CI 0.93-1.39). Multivariate adjustment only slightly modified the 25(OH)D-mortality association. CONCLUSION: 25(OH)D was similarly inversely related to all-cause mortality in men and women. However, we observed opposite effects in women and men with respect to cardiovascular and cancer mortality. SN - 1590-3729 UR - https://www.unboundmedicine.com/medline/citation/24095147/Inverse_association_between_circulating_vitamin_D_and_mortality__dependent_on_sex_and_cause_of_death DB - PRIME DP - Unbound Medicine ER -