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Effects of accelerated senescence on learning and memory, locomotion and anxiety-like behavior in APP/PS1 mouse model of Alzheimer's disease.

Abstract

Alzheimer's disease (AD) is characterized by a deficit in motor and spatial learning-memory and alteration of non-cognitive behavior. The generation of transgenic mice with presence of AD pathologies that cause learning and memory deficits has led to improved understanding of the behavioral and pathophysiological processes underlying AD. A novel APP/PS1 mouse model in the senescence accelerated mouse prone 8 (SAMP8) background--SAMP8 APP/PS1 was generated. To assess the behavioral and other AD-related changes in this SAMP8 APP/PS1 model, the present report covers a phenotypical analysis of this model for working memory, spatial memory, motor performance and anxiety-like behavior. SAMP8 APP/PS1 mice showed motor and spatial memory impairments, together with an increase of locomotor activity and lower anxiety-like behavior at 9months old. In contrast, C57 APP/PS1 and SAMP8 wild type mice were inconspicuous in all of these tasks and properties except C57 APP/PS1 mice which showed motor memory impairment in the shuttle box task at 9 months old. Standard senescence-associated beta-galactosidase (SA-beta-GAL) staining and amyloid beta (Aβ) immunohistochemistry showed more severe pathological changes in the SAMP8 APP/PS1 mice. SAMP8 APP/PS1 mice exhibited earlier deficits in their non-cognitive and cognitive behaviors which are coincident in the AD patient and the results suggest that this new type of mice might be a better model for studying the age-related dementia of the Alzheimer type and for assessing the potential therapeutic agents for AD.

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  • Authors+Show Affiliations

    ,

    School of Pharmacy, Shanghai Jiao Tong University, 200240 Shanghai, China.

    , , , , , ,

    Source

    Journal of the neurological sciences 335:1-2 2013 Dec 15 pg 145-54

    MeSH

    Aging
    Alzheimer Disease
    Amyloid beta-Peptides
    Amyloid beta-Protein Precursor
    Animals
    Anxiety
    Disease Models, Animal
    Escape Reaction
    Exploratory Behavior
    Gait Disorders, Neurologic
    Genotype
    Humans
    Learning Disorders
    Maze Learning
    Mice
    Mice, Inbred C57BL
    Mice, Transgenic
    Presenilin-1

    Pub Type(s)

    Journal Article
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    24095271

    Citation

    Lok, Kenghoe, et al. "Effects of Accelerated Senescence On Learning and Memory, Locomotion and Anxiety-like Behavior in APP/PS1 Mouse Model of Alzheimer's Disease." Journal of the Neurological Sciences, vol. 335, no. 1-2, 2013, pp. 145-54.
    Lok K, Zhao H, Zhang C, et al. Effects of accelerated senescence on learning and memory, locomotion and anxiety-like behavior in APP/PS1 mouse model of Alzheimer's disease. J Neurol Sci. 2013;335(1-2):145-54.
    Lok, K., Zhao, H., Zhang, C., He, N., Shen, H., Wang, Z., ... Yin, M. (2013). Effects of accelerated senescence on learning and memory, locomotion and anxiety-like behavior in APP/PS1 mouse model of Alzheimer's disease. Journal of the Neurological Sciences, 335(1-2), pp. 145-54. doi:10.1016/j.jns.2013.09.018.
    Lok K, et al. Effects of Accelerated Senescence On Learning and Memory, Locomotion and Anxiety-like Behavior in APP/PS1 Mouse Model of Alzheimer's Disease. J Neurol Sci. 2013 Dec 15;335(1-2):145-54. PubMed PMID: 24095271.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Effects of accelerated senescence on learning and memory, locomotion and anxiety-like behavior in APP/PS1 mouse model of Alzheimer's disease. AU - Lok,Kenghoe, AU - Zhao,Hong, AU - Zhang,Can, AU - He,Na, AU - Shen,Hanlin, AU - Wang,Zejian, AU - Zhao,Wenjuan, AU - Yin,Ming, Y1 - 2013/09/21/ PY - 2013/05/13/received PY - 2013/09/12/revised PY - 2013/09/13/accepted PY - 2013/10/8/entrez PY - 2013/10/8/pubmed PY - 2014/7/8/medline KW - AD KW - APP KW - APP/PS1 KW - Alzheimer's disease KW - Anxiety KW - Aβ KW - CS KW - Learning–memory KW - Locomotor KW - NFTs KW - PS1 KW - PS2 KW - SAMP8 KW - Senescence KW - TBS KW - UCS KW - amyloid beta KW - amyloid precursor protein KW - conditioned stimulus KW - neurofibrillary tangles KW - presenilin 1 KW - presenilin 2 KW - senescence accelerated mouse prone 8 KW - tris-buffered saline KW - unconditioned stimulus SP - 145 EP - 54 JF - Journal of the neurological sciences JO - J. Neurol. Sci. VL - 335 IS - 1-2 N2 - Alzheimer's disease (AD) is characterized by a deficit in motor and spatial learning-memory and alteration of non-cognitive behavior. The generation of transgenic mice with presence of AD pathologies that cause learning and memory deficits has led to improved understanding of the behavioral and pathophysiological processes underlying AD. A novel APP/PS1 mouse model in the senescence accelerated mouse prone 8 (SAMP8) background--SAMP8 APP/PS1 was generated. To assess the behavioral and other AD-related changes in this SAMP8 APP/PS1 model, the present report covers a phenotypical analysis of this model for working memory, spatial memory, motor performance and anxiety-like behavior. SAMP8 APP/PS1 mice showed motor and spatial memory impairments, together with an increase of locomotor activity and lower anxiety-like behavior at 9months old. In contrast, C57 APP/PS1 and SAMP8 wild type mice were inconspicuous in all of these tasks and properties except C57 APP/PS1 mice which showed motor memory impairment in the shuttle box task at 9 months old. Standard senescence-associated beta-galactosidase (SA-beta-GAL) staining and amyloid beta (Aβ) immunohistochemistry showed more severe pathological changes in the SAMP8 APP/PS1 mice. SAMP8 APP/PS1 mice exhibited earlier deficits in their non-cognitive and cognitive behaviors which are coincident in the AD patient and the results suggest that this new type of mice might be a better model for studying the age-related dementia of the Alzheimer type and for assessing the potential therapeutic agents for AD. SN - 1878-5883 UR - https://www.unboundmedicine.com/medline/citation/24095271/Effects_of_accelerated_senescence_on_learning_and_memory_locomotion_and_anxiety_like_behavior_in_APP/PS1_mouse_model_of_Alzheimer's_disease_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0022-510X(13)02927-4 DB - PRIME DP - Unbound Medicine ER -