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Anti-hyperglycemic and hypolipidemic effects of Cistanche tubulosa in type 2 diabetic db/db mice.
J Ethnopharmacol. 2013 Dec 12; 150(3):935-45.JE

Abstract

ETHNOPHARMACOLOGICAL RELEVANCE

The dried succulent stem of Cistanche tubulosa (Schenk) R. Wight is one component of traditional Chinese medicine prescriptions for diabetes. However, there have been no modern scientific reports to confirm this traditional claim for the Cistanche species until now. Thus, we investigated the effects of Cistanche tubulosa on glucose homeostasis and serum lipids in male BKS.Cg-Dock7(m) +/+ Lepr(db)/J (db/db) mice, a model of type 2 diabetes.

MATERIALS AND METHODS

The verbascoside and echinacoside contents of Cistanche tubulosa powder were evaluated using HPLC. The total phenolic content, polysaccharide content and antioxidant activity of Cistanche tubulosa powder were also evaluated. Then, different doses of Cistanche tubulosa (equivalent to 120.9, 72.6 or 24.2mg verbascoside/kg) were administered orally once daily for 45 days to male db/db mice. Age matched db/+ mice were used as normal controls. Body weight, fasting blood glucose, postprandial blood glucose and insulin tolerance test were measured during the experiment. At the time of sacrifice, blood was collected for measurement of insulin level, the homeostatic model assessment of insulin resistance (HOMA-IR), and total cholesterol, triglyceride, HDL-c, LDL-c and VLDL-c levels; liver and muscle were harvested for measurement of glycogen levels.

RESULTS

Cistanche tubulosa significantly suppressed the elevated fasting blood glucose and postprandial blood glucose levels, improved insulin resistance and dyslipidemia, and suppressed body weight loss in db/db mice. However, Cistanche tubulosa did not significantly affect serum insulin levels or hepatic and muscle glycogen levels.

CONCLUSION

This study provides scientific evidence for the traditional use of Cistanche tubulosa to treat diabetes, suggesting that Cistanche tubulosa has the potential for development into a functional food ingredient or drug to prevent hyperglycemia and treat hyperlipidemia.

Authors+Show Affiliations

Food and Health Engineering Research Center of State Education Ministry, School of Life Sciences, Sun Yat-sen University, Guangzhou 510275, PR China. Electronic address: wentingxiong8@gmail.com.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

24095831

Citation

Xiong, Wen-Ting, et al. "Anti-hyperglycemic and Hypolipidemic Effects of Cistanche Tubulosa in Type 2 Diabetic Db/db Mice." Journal of Ethnopharmacology, vol. 150, no. 3, 2013, pp. 935-45.
Xiong WT, Gu L, Wang C, et al. Anti-hyperglycemic and hypolipidemic effects of Cistanche tubulosa in type 2 diabetic db/db mice. J Ethnopharmacol. 2013;150(3):935-45.
Xiong, W. T., Gu, L., Wang, C., Sun, H. X., & Liu, X. (2013). Anti-hyperglycemic and hypolipidemic effects of Cistanche tubulosa in type 2 diabetic db/db mice. Journal of Ethnopharmacology, 150(3), 935-45. https://doi.org/10.1016/j.jep.2013.09.027
Xiong WT, et al. Anti-hyperglycemic and Hypolipidemic Effects of Cistanche Tubulosa in Type 2 Diabetic Db/db Mice. J Ethnopharmacol. 2013 Dec 12;150(3):935-45. PubMed PMID: 24095831.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Anti-hyperglycemic and hypolipidemic effects of Cistanche tubulosa in type 2 diabetic db/db mice. AU - Xiong,Wen-Ting, AU - Gu,Li, AU - Wang,Chao, AU - Sun,Hong-Xia, AU - Liu,Xin, Y1 - 2013/10/01/ PY - 2013/03/28/received PY - 2013/07/22/revised PY - 2013/09/10/accepted PY - 2013/10/8/entrez PY - 2013/10/8/pubmed PY - 2014/8/26/medline KW - AB KW - Anti-hyperglycemic effect KW - BW KW - CT KW - Cistanche tubulosa KW - DM KW - Diabetes mellitus KW - FBG KW - FINS KW - Fasting Serum Insulin Level KW - HDL-c KW - HOMA-IR KW - Homeostatic Model Assessment of Insulin Resistance KW - Hypolipidemic effect KW - ITT KW - LDL-c KW - PPRC KW - PhGs KW - Pharmacopoeia of the People's Republic of China KW - RG KW - TC KW - TG KW - Type 2 diabetes KW - VLDL-c KW - acarbose KW - body weight KW - fasting blood glucose KW - high-density lipoprotein cholesterol KW - insulin tolerance test KW - low-density lipoprotein cholesterol KW - phenylethanoid glycosides KW - rosiglitazone KW - total cholesterol KW - triglycerides KW - very low-density lipoprotein cholesterol SP - 935 EP - 45 JF - Journal of ethnopharmacology JO - J Ethnopharmacol VL - 150 IS - 3 N2 - ETHNOPHARMACOLOGICAL RELEVANCE: The dried succulent stem of Cistanche tubulosa (Schenk) R. Wight is one component of traditional Chinese medicine prescriptions for diabetes. However, there have been no modern scientific reports to confirm this traditional claim for the Cistanche species until now. Thus, we investigated the effects of Cistanche tubulosa on glucose homeostasis and serum lipids in male BKS.Cg-Dock7(m) +/+ Lepr(db)/J (db/db) mice, a model of type 2 diabetes. MATERIALS AND METHODS: The verbascoside and echinacoside contents of Cistanche tubulosa powder were evaluated using HPLC. The total phenolic content, polysaccharide content and antioxidant activity of Cistanche tubulosa powder were also evaluated. Then, different doses of Cistanche tubulosa (equivalent to 120.9, 72.6 or 24.2mg verbascoside/kg) were administered orally once daily for 45 days to male db/db mice. Age matched db/+ mice were used as normal controls. Body weight, fasting blood glucose, postprandial blood glucose and insulin tolerance test were measured during the experiment. At the time of sacrifice, blood was collected for measurement of insulin level, the homeostatic model assessment of insulin resistance (HOMA-IR), and total cholesterol, triglyceride, HDL-c, LDL-c and VLDL-c levels; liver and muscle were harvested for measurement of glycogen levels. RESULTS: Cistanche tubulosa significantly suppressed the elevated fasting blood glucose and postprandial blood glucose levels, improved insulin resistance and dyslipidemia, and suppressed body weight loss in db/db mice. However, Cistanche tubulosa did not significantly affect serum insulin levels or hepatic and muscle glycogen levels. CONCLUSION: This study provides scientific evidence for the traditional use of Cistanche tubulosa to treat diabetes, suggesting that Cistanche tubulosa has the potential for development into a functional food ingredient or drug to prevent hyperglycemia and treat hyperlipidemia. SN - 1872-7573 UR - https://www.unboundmedicine.com/medline/citation/24095831/Anti_hyperglycemic_and_hypolipidemic_effects_of_Cistanche_tubulosa_in_type_2_diabetic_db/db_mice_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0378-8741(13)00674-0 DB - PRIME DP - Unbound Medicine ER -