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A new stress model, a scream sound, alters learning and monoamine levels in rat brain.
Physiol Behav 2014; 123:105-13PB

Abstract

Most existing animal models for stress involve the simultaneous application of physical and psychological stress factors. In the current study, we described and used a novel psychological stress model (scream sound stress). To study the validity of it, we carried out acute and chronic scream sound stress. First, adult Sprague-Dawley (SD) rats were randomly divided into white noise, stress and background groups. The white noise group and stress group were treated with white noise and scream sound for 4h in the morning respectively. Compared with white noise and background groups, exposure to acute scream sound increased corticosterone (CORT) level and decreased latency in Morris water maze (MWM) test. The levels of noradrenaline (NE), dopamine (DA), 5-hydroxytryptamine (5-HT), 3,4-dihydroxyphenylacetic acid (DOPAC), homovanillic acid (HVA) and 5-hydroxyindoleacetic acid (5-HIAA) were altered in the striatum, hypothalamus and hippocampus of stress rats. Second, adult SD rats were randomly divided into background and stress groups, which were treated with scream sound for three weeks. Exposure to chronic scream sound suppressed body weight gain, increased corticosterone (CORT) level, influenced the morphology of adrenal gland, improved spleen and thymus indices, and decreased latency in MWM test. NE, DA, DOPAC, HVA and 5-HIAA levels were also altered in the brain of stress rats. Our results suggested that scream sound, as a novel stressor, facilitated learning ability, as well as altered monoamine levels in the rat brain. Moreover, scream sound is easy to apply and can be applied in more animals at the same time.

Authors+Show Affiliations

Department of Genetics and Molecular Biology, Xi'an Jiaotong University College of Medicine, Xi'an, Shaanxi, China.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

24096192

Citation

Hu, Lili, et al. "A New Stress Model, a Scream Sound, Alters Learning and Monoamine Levels in Rat Brain." Physiology & Behavior, vol. 123, 2014, pp. 105-13.
Hu L, Yang J, Song T, et al. A new stress model, a scream sound, alters learning and monoamine levels in rat brain. Physiol Behav. 2014;123:105-13.
Hu, L., Yang, J., Song, T., Hou, N., Liu, Y., Zhao, X., ... Huang, C. (2014). A new stress model, a scream sound, alters learning and monoamine levels in rat brain. Physiology & Behavior, 123, pp. 105-13. doi:10.1016/j.physbeh.2013.09.010.
Hu L, et al. A New Stress Model, a Scream Sound, Alters Learning and Monoamine Levels in Rat Brain. Physiol Behav. 2014 Jan 17;123:105-13. PubMed PMID: 24096192.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - A new stress model, a scream sound, alters learning and monoamine levels in rat brain. AU - Hu,Lili, AU - Yang,Juan, AU - Song,Tusheng, AU - Hou,Ni, AU - Liu,Yong, AU - Zhao,Xiaoge, AU - Zhang,Dianzeng, AU - Wang,Lumin, AU - Wang,Tao, AU - Huang,Chen, Y1 - 2013/10/02/ PY - 2013/04/19/received PY - 2013/08/25/revised PY - 2013/09/23/accepted PY - 2013/10/8/entrez PY - 2013/10/8/pubmed PY - 2014/7/18/medline KW - 3,4-dihydroxyphenylacetic acid KW - 3,4-dihydroxyphenylacetic acid/dopamine KW - 5-HIAA KW - 5-HT KW - 5-hydroxyindoleacetic acid KW - 5-hydroxytryptamine KW - ANOVA KW - Brain KW - CORT KW - DA KW - DOPAC KW - DOPAC/DA KW - HPA KW - HPLC-ECD KW - HVA KW - Learning KW - Monoamine KW - NE (NA) KW - Scream sound stress KW - ZF KW - ZG KW - ZR KW - analysis of variance KW - corticosterone KW - dopamine KW - high performance liquid chromatography with electrochemical detector KW - homovanillic acid KW - hypothalamus pituitary adrenal KW - norepinephrine, noradrenaline KW - zona fasciculata KW - zona glomerulosa KW - zona reticularis SP - 105 EP - 13 JF - Physiology & behavior JO - Physiol. Behav. VL - 123 N2 - Most existing animal models for stress involve the simultaneous application of physical and psychological stress factors. In the current study, we described and used a novel psychological stress model (scream sound stress). To study the validity of it, we carried out acute and chronic scream sound stress. First, adult Sprague-Dawley (SD) rats were randomly divided into white noise, stress and background groups. The white noise group and stress group were treated with white noise and scream sound for 4h in the morning respectively. Compared with white noise and background groups, exposure to acute scream sound increased corticosterone (CORT) level and decreased latency in Morris water maze (MWM) test. The levels of noradrenaline (NE), dopamine (DA), 5-hydroxytryptamine (5-HT), 3,4-dihydroxyphenylacetic acid (DOPAC), homovanillic acid (HVA) and 5-hydroxyindoleacetic acid (5-HIAA) were altered in the striatum, hypothalamus and hippocampus of stress rats. Second, adult SD rats were randomly divided into background and stress groups, which were treated with scream sound for three weeks. Exposure to chronic scream sound suppressed body weight gain, increased corticosterone (CORT) level, influenced the morphology of adrenal gland, improved spleen and thymus indices, and decreased latency in MWM test. NE, DA, DOPAC, HVA and 5-HIAA levels were also altered in the brain of stress rats. Our results suggested that scream sound, as a novel stressor, facilitated learning ability, as well as altered monoamine levels in the rat brain. Moreover, scream sound is easy to apply and can be applied in more animals at the same time. SN - 1873-507X UR - https://www.unboundmedicine.com/medline/citation/24096192/A_new_stress_model_a_scream_sound_alters_learning_and_monoamine_levels_in_rat_brain_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0031-9384(13)00307-7 DB - PRIME DP - Unbound Medicine ER -