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Age and psychological influences on immune responses to trivalent inactivated influenza vaccine in the meditation or exercise for preventing acute respiratory infection (MEPARI) trial.
Hum Vaccin Immunother. 2014; 10(1):83-91.HV

Abstract

BACKGROUND

Strategies to improve influenza vaccine protection among elderly individuals are an important research priority. Mindfulness-based stress reduction (MBSR) and exercise have been shown to affect aspects of immune function in some populations. We hypothesized that influenza vaccine responses may be enhanced with meditation or exercise training as compared with controls.

RESULTS

No differences in vaccine responses were found comparing control to MBSR or exercise. Individuals achieving seroprotective levels of influenza antibody ≥160 units had higher optimism, less anxiety, and lower perceived stress than the nonresponders. Age correlated with influenza antibody responses, but not with IFNγ or IL-10 production.

CONCLUSION

The MBSR and exercise training evaluated in this study failed to enhance immune responses to influenza vaccine. However, optimism, perceived stress, and anxiety were correlated in the expected directions with antibody responses to influenza vaccine.

METHODS

Healthy individuals≥50 y were randomly assigned to exercise (n=47) or MBSR (n=51) training or a waitlist control condition (n=51). Each participant received trivalent inactivated influenza vaccine after 6 weeks, and had blood draws prior to and 3 and 12 weeks after immunization. Serum influenza antibody, nasal immunoglobulin A, and peripheral blood mononuclear cell interferon-γ (IFNγ) and interleukin-10 (IL-10) concentrations were measured. Measures of optimism, perceived stress, and anxiety were obtained over the course of the study. Seroprotection was defined as an influenza antibody concentration≥160 units. Vaccine responses were compared using ANOVA, t tests, and Kruskal-Wallis tests. The correlation between vaccine responses and age was examined with the Pearson test.

Authors+Show Affiliations

School of Pharmacy; University of Wisconsin-Madison; Madison, WI USA.Harlow Center for Biological Psychology; University of Wisconsin-Madison; Madison, WI USA.Department of Medicine-Rheumatology Division; University of Wisconsin-Madison; School of Medicine and Public Health; Madison, WI USA.Department of Family Medicine; University of Wisconsin-Madison; School of Medicine and Public Health; Madison, WI USA.School of Nursing; University of Wisconsin-Madison; Madison, WI USA.Department of Family Medicine; University of Wisconsin-Madison; School of Medicine and Public Health; Madison, WI USA.Department of Family Medicine; University of Wisconsin-Madison; School of Medicine and Public Health; Madison, WI USA.

Pub Type(s)

Journal Article
Randomized Controlled Trial
Research Support, N.I.H., Extramural

Language

eng

PubMed ID

24096366

Citation

Hayney, Mary S., et al. "Age and Psychological Influences On Immune Responses to Trivalent Inactivated Influenza Vaccine in the Meditation or Exercise for Preventing Acute Respiratory Infection (MEPARI) Trial." Human Vaccines & Immunotherapeutics, vol. 10, no. 1, 2014, pp. 83-91.
Hayney MS, Coe CL, Muller D, et al. Age and psychological influences on immune responses to trivalent inactivated influenza vaccine in the meditation or exercise for preventing acute respiratory infection (MEPARI) trial. Hum Vaccin Immunother. 2014;10(1):83-91.
Hayney, M. S., Coe, C. L., Muller, D., Obasi, C. N., Backonja, U., Ewers, T., & Barrett, B. (2014). Age and psychological influences on immune responses to trivalent inactivated influenza vaccine in the meditation or exercise for preventing acute respiratory infection (MEPARI) trial. Human Vaccines & Immunotherapeutics, 10(1), 83-91. https://doi.org/10.4161/hv.26661
Hayney MS, et al. Age and Psychological Influences On Immune Responses to Trivalent Inactivated Influenza Vaccine in the Meditation or Exercise for Preventing Acute Respiratory Infection (MEPARI) Trial. Hum Vaccin Immunother. 2014;10(1):83-91. PubMed PMID: 24096366.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Age and psychological influences on immune responses to trivalent inactivated influenza vaccine in the meditation or exercise for preventing acute respiratory infection (MEPARI) trial. AU - Hayney,Mary S, AU - Coe,Christopher L, AU - Muller,Daniel, AU - Obasi,Chidi N, AU - Backonja,Uba, AU - Ewers,Tola, AU - Barrett,Bruce, Y1 - 2013/10/07/ PY - 2013/10/8/entrez PY - 2013/10/8/pubmed PY - 2015/1/6/medline KW - aging KW - antibody KW - body mass index KW - cytokine KW - exercise KW - influenza vaccine KW - interferon-γ KW - interleukin-10 KW - meditation KW - positive emotion KW - stress SP - 83 EP - 91 JF - Human vaccines & immunotherapeutics JO - Hum Vaccin Immunother VL - 10 IS - 1 N2 - BACKGROUND: Strategies to improve influenza vaccine protection among elderly individuals are an important research priority. Mindfulness-based stress reduction (MBSR) and exercise have been shown to affect aspects of immune function in some populations. We hypothesized that influenza vaccine responses may be enhanced with meditation or exercise training as compared with controls. RESULTS: No differences in vaccine responses were found comparing control to MBSR or exercise. Individuals achieving seroprotective levels of influenza antibody ≥160 units had higher optimism, less anxiety, and lower perceived stress than the nonresponders. Age correlated with influenza antibody responses, but not with IFNγ or IL-10 production. CONCLUSION: The MBSR and exercise training evaluated in this study failed to enhance immune responses to influenza vaccine. However, optimism, perceived stress, and anxiety were correlated in the expected directions with antibody responses to influenza vaccine. METHODS: Healthy individuals≥50 y were randomly assigned to exercise (n=47) or MBSR (n=51) training or a waitlist control condition (n=51). Each participant received trivalent inactivated influenza vaccine after 6 weeks, and had blood draws prior to and 3 and 12 weeks after immunization. Serum influenza antibody, nasal immunoglobulin A, and peripheral blood mononuclear cell interferon-γ (IFNγ) and interleukin-10 (IL-10) concentrations were measured. Measures of optimism, perceived stress, and anxiety were obtained over the course of the study. Seroprotection was defined as an influenza antibody concentration≥160 units. Vaccine responses were compared using ANOVA, t tests, and Kruskal-Wallis tests. The correlation between vaccine responses and age was examined with the Pearson test. SN - 2164-554X UR - https://www.unboundmedicine.com/medline/citation/24096366/Age_and_psychological_influences_on_immune_responses_to_trivalent_inactivated_influenza_vaccine_in_the_meditation_or_exercise_for_preventing_acute_respiratory_infection__MEPARI__trial_ L2 - http://www.tandfonline.com/doi/full/10.4161/hv.26661 DB - PRIME DP - Unbound Medicine ER -