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Blood trace minerals concentrations and oxidative stress in patients with obstructive sleep apnea.
J Nutr Health Aging 2013; 17(8):639-44JN

Abstract

BACKGROUND

Obstructive sleep apnea (OSA) is associated with increased oxidative stress. Certain essential trace minerals have shown to play an important role in the maintenance of redox homeostasis. We determined the concentrations of trace minerals in OSA patients and assessed their relationships to OSA severity as indicated by the apnea/ hypopnea index (AHI).

METHODS

We enrolled 44 patients with newly diagnosed mild to moderate OSA and 20 without OSA. The following parameters were measured: polysomnographic values of nocturnal sleep; plasma trace minerals zinc (Zn), copper (Cu), iron (Fe), and erythrocyte selenium (Se); oxidative stress status; and plasma high-sensitivity C-reactive protein (hs-CRP) and tumor necrosis factor-α (TNF-α).

RESULTS

Compared to controls matched for age, gender, and body mass index, OSA patients had lower concentrations of plasma Zn and erythrocyte Se and higher plasma concentrations of Cu and Fe. OSA patients had significantly higher plasma concentrations of hs-CRP, TNF-α, and malondialdehyde (MDA), and lower erythrocyte antioxidant enzyme glutathione peroxidase (GPx) and superoxide dismutase activities. Significant differences in all the above parameters were also found in patients with moderate OSA compared to those with mild OSA. Furthermore, AHI values correlated significantly with neck circumference, GPx activity, and MDA, hs-CRP, and TNF-α concentrations in OSA patients. AHI values were also negatively associated with concentrations of plasma Zn and erythrocyte Se, but were positively linked to plasma concentrations of Fe and Cu.

CONCLUSIONS

Abnormal concentrations of these trace minerals may reflect oxidative damage and inflammatory response, thus increasing the severity of OSA.

Authors+Show Affiliations

Po-Jen Liu, Department of Otolaryngology and Nutrition and Naturopathic center, Cheng-Ching Hospital, Taiwan Boulevard, Taichung 407, Taiwan, Republic of China. xz48899959@gmail.com, Tel:886-4-2463-2000 ext. 53664, Fax:886-4-2463-5961.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

24097016

Citation

Chen, P C., et al. "Blood Trace Minerals Concentrations and Oxidative Stress in Patients With Obstructive Sleep Apnea." The Journal of Nutrition, Health & Aging, vol. 17, no. 8, 2013, pp. 639-44.
Chen PC, Guo CH, Tseng CJ, et al. Blood trace minerals concentrations and oxidative stress in patients with obstructive sleep apnea. J Nutr Health Aging. 2013;17(8):639-44.
Chen, P. C., Guo, C. H., Tseng, C. J., Wang, K. C., & Liu, P. J. (2013). Blood trace minerals concentrations and oxidative stress in patients with obstructive sleep apnea. The Journal of Nutrition, Health & Aging, 17(8), pp. 639-44. doi:10.1007/s12603-013-0023-x.
Chen PC, et al. Blood Trace Minerals Concentrations and Oxidative Stress in Patients With Obstructive Sleep Apnea. J Nutr Health Aging. 2013;17(8):639-44. PubMed PMID: 24097016.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Blood trace minerals concentrations and oxidative stress in patients with obstructive sleep apnea. AU - Chen,P C, AU - Guo,C H, AU - Tseng,C J, AU - Wang,K C, AU - Liu,P J, PY - 2013/10/8/entrez PY - 2013/10/8/pubmed PY - 2014/4/22/medline SP - 639 EP - 44 JF - The journal of nutrition, health & aging JO - J Nutr Health Aging VL - 17 IS - 8 N2 - BACKGROUND: Obstructive sleep apnea (OSA) is associated with increased oxidative stress. Certain essential trace minerals have shown to play an important role in the maintenance of redox homeostasis. We determined the concentrations of trace minerals in OSA patients and assessed their relationships to OSA severity as indicated by the apnea/ hypopnea index (AHI). METHODS: We enrolled 44 patients with newly diagnosed mild to moderate OSA and 20 without OSA. The following parameters were measured: polysomnographic values of nocturnal sleep; plasma trace minerals zinc (Zn), copper (Cu), iron (Fe), and erythrocyte selenium (Se); oxidative stress status; and plasma high-sensitivity C-reactive protein (hs-CRP) and tumor necrosis factor-α (TNF-α). RESULTS: Compared to controls matched for age, gender, and body mass index, OSA patients had lower concentrations of plasma Zn and erythrocyte Se and higher plasma concentrations of Cu and Fe. OSA patients had significantly higher plasma concentrations of hs-CRP, TNF-α, and malondialdehyde (MDA), and lower erythrocyte antioxidant enzyme glutathione peroxidase (GPx) and superoxide dismutase activities. Significant differences in all the above parameters were also found in patients with moderate OSA compared to those with mild OSA. Furthermore, AHI values correlated significantly with neck circumference, GPx activity, and MDA, hs-CRP, and TNF-α concentrations in OSA patients. AHI values were also negatively associated with concentrations of plasma Zn and erythrocyte Se, but were positively linked to plasma concentrations of Fe and Cu. CONCLUSIONS: Abnormal concentrations of these trace minerals may reflect oxidative damage and inflammatory response, thus increasing the severity of OSA. SN - 1760-4788 UR - https://www.unboundmedicine.com/medline/citation/24097016/Blood_trace_minerals_concentrations_and_oxidative_stress_in_patients_with_obstructive_sleep_apnea_ L2 - http://www.diseaseinfosearch.org/result/6636 DB - PRIME DP - Unbound Medicine ER -