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Cyclo(L-Pro-D-Arg): a new antibacterial and antitumour diketopiperazine from Bacillus cereus associated with a rhabditid entomopathogenic.
Folia Microbiol (Praha). 2014 May; 59(3):197-202.FM

Abstract

In continuation of our search for new antimicrobial secondary metabolites from Bacillus cereus associated with rhabditid entomopathogenic nematode, a new microbial diketopiperazine, cyclo(L-Pro-D-Arg), was isolated from the ethyl acetate extract of fermented modified nutrient broth. The chemical structures of the isolated compounds were identified based on their 1D, 2D NMR and high-resolution electrospray ionisation-mass spectroscopy data. Antibacterial activity of the compound was determined by minimum inhibitory concentration and disc diffusion method against medically important bacteria, and the compound was recorded to have significant antibacterial activity against test bacteria. The highest activity was recorded against Klebsiella pneumoniae (1 μg/mL). Cyclo(L-Pro-D-Arg) was recorded to have significant antitumor activity against HeLa cells (IC50 value 50 μg/mL), and this compound was recorded to have no cytotoxicity against normal monkey kidney cells (VERO) up to 100 μg/mL). To the best of our knowledge, this is the first time that cyclo(L-Pro-D-Arg) has been isolated from a microbial natural source.

Authors+Show Affiliations

Division of Crop Protection/Division of Crop Utilisation, Central Tuber Crops Research Institute, Sreekariyam, Thiruvananthapuram, 695017, India, micronishanth@rediffmail.com.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

24097052

Citation

Kumar, S Nishanth, et al. "Cyclo(L-Pro-D-Arg): a New Antibacterial and Antitumour Diketopiperazine From Bacillus Cereus Associated With a Rhabditid Entomopathogenic." Folia Microbiologica, vol. 59, no. 3, 2014, pp. 197-202.
Kumar SN, Mohandas C, Nambisan B, et al. Cyclo(L-Pro-D-Arg): a new antibacterial and antitumour diketopiperazine from Bacillus cereus associated with a rhabditid entomopathogenic. Folia Microbiol (Praha). 2014;59(3):197-202.
Kumar, S. N., Mohandas, C., Nambisan, B., Sreerag, R. S., & Jayaprakas, C. A. (2014). Cyclo(L-Pro-D-Arg): a new antibacterial and antitumour diketopiperazine from Bacillus cereus associated with a rhabditid entomopathogenic. Folia Microbiologica, 59(3), 197-202. https://doi.org/10.1007/s12223-013-0282-2
Kumar SN, et al. Cyclo(L-Pro-D-Arg): a New Antibacterial and Antitumour Diketopiperazine From Bacillus Cereus Associated With a Rhabditid Entomopathogenic. Folia Microbiol (Praha). 2014;59(3):197-202. PubMed PMID: 24097052.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Cyclo(L-Pro-D-Arg): a new antibacterial and antitumour diketopiperazine from Bacillus cereus associated with a rhabditid entomopathogenic. AU - Kumar,S Nishanth, AU - Mohandas,C, AU - Nambisan,Bala, AU - Sreerag,R S, AU - Jayaprakas,C A, Y1 - 2013/10/05/ PY - 2013/06/06/received PY - 2013/09/20/accepted PY - 2013/10/8/entrez PY - 2013/10/8/pubmed PY - 2015/1/24/medline SP - 197 EP - 202 JF - Folia microbiologica JO - Folia Microbiol (Praha) VL - 59 IS - 3 N2 - In continuation of our search for new antimicrobial secondary metabolites from Bacillus cereus associated with rhabditid entomopathogenic nematode, a new microbial diketopiperazine, cyclo(L-Pro-D-Arg), was isolated from the ethyl acetate extract of fermented modified nutrient broth. The chemical structures of the isolated compounds were identified based on their 1D, 2D NMR and high-resolution electrospray ionisation-mass spectroscopy data. Antibacterial activity of the compound was determined by minimum inhibitory concentration and disc diffusion method against medically important bacteria, and the compound was recorded to have significant antibacterial activity against test bacteria. The highest activity was recorded against Klebsiella pneumoniae (1 μg/mL). Cyclo(L-Pro-D-Arg) was recorded to have significant antitumor activity against HeLa cells (IC50 value 50 μg/mL), and this compound was recorded to have no cytotoxicity against normal monkey kidney cells (VERO) up to 100 μg/mL). To the best of our knowledge, this is the first time that cyclo(L-Pro-D-Arg) has been isolated from a microbial natural source. SN - 1874-9356 UR - https://www.unboundmedicine.com/medline/citation/24097052/Cyclo_L_Pro_D_Arg_:_a_new_antibacterial_and_antitumour_diketopiperazine_from_Bacillus_cereus_associated_with_a_rhabditid_entomopathogenic_ L2 - https://dx.doi.org/10.1007/s12223-013-0282-2 DB - PRIME DP - Unbound Medicine ER -