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Antifungal dimeric chalcone derivative kamalachalcone E from Mallotus philippinensis.
Nat Prod Res. 2014; 28(4):245-50.NP

Abstract

From the red coloured extract (Kamala) prepared through acetone extraction of the fresh whole uncrushed fruits of Mallotus philippinensis, one new dimeric chalcone (1) along with three known compounds 1-(5,7-dihydroxy-2,2,6-trimethyl-2H-1-benzopyran-8-yl)-3-phenyl-2-propen-1-one (2), rottlerin (3) and 4'-hydroxyrottlerin (4) were isolated. The structure of compound 1 was elucidated by 1D and 2D NMR analyses that included HSQC, HMBC, COSY and ROESY experiments along with the literature comparison. Compounds 1-4 were evaluated for antifungal activity against different human pathogenic yeasts and filamentous fungi. The antiproliferative activity of the compounds was evaluated against Thp-1 cell lines. Compounds 1 and 2 both exhibited IC50 of 8, 4 and 16 μg/mL against Cryptococcus neoformans PRL518, C. neoformans ATCC32045 and Aspergillus fumigatus, respectively. Compound 4, at 100 μg/mL, showed 54% growth inhibition of Thp-1 cell lines.

Authors+Show Affiliations

a Division of Organic Chemistry, CSIR-National Chemical Laboratory , Pune 411008 , India.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

24099509

Citation

Kulkarni, Roshan R., et al. "Antifungal Dimeric Chalcone Derivative Kamalachalcone E From Mallotus Philippinensis." Natural Product Research, vol. 28, no. 4, 2014, pp. 245-50.
Kulkarni RR, Tupe SG, Gample SP, et al. Antifungal dimeric chalcone derivative kamalachalcone E from Mallotus philippinensis. Nat Prod Res. 2014;28(4):245-50.
Kulkarni, R. R., Tupe, S. G., Gample, S. P., Chandgude, M. G., Sarkar, D., Deshpande, M. V., & Joshi, S. P. (2014). Antifungal dimeric chalcone derivative kamalachalcone E from Mallotus philippinensis. Natural Product Research, 28(4), 245-50. https://doi.org/10.1080/14786419.2013.843178
Kulkarni RR, et al. Antifungal Dimeric Chalcone Derivative Kamalachalcone E From Mallotus Philippinensis. Nat Prod Res. 2014;28(4):245-50. PubMed PMID: 24099509.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Antifungal dimeric chalcone derivative kamalachalcone E from Mallotus philippinensis. AU - Kulkarni,Roshan R, AU - Tupe,Santosh G, AU - Gample,Suwarna P, AU - Chandgude,Macchindra G, AU - Sarkar,Dhiman, AU - Deshpande,Mukund V, AU - Joshi,Swati P, Y1 - 2013/10/07/ PY - 2013/10/9/entrez PY - 2013/10/9/pubmed PY - 2014/9/6/medline SP - 245 EP - 50 JF - Natural product research JO - Nat Prod Res VL - 28 IS - 4 N2 - From the red coloured extract (Kamala) prepared through acetone extraction of the fresh whole uncrushed fruits of Mallotus philippinensis, one new dimeric chalcone (1) along with three known compounds 1-(5,7-dihydroxy-2,2,6-trimethyl-2H-1-benzopyran-8-yl)-3-phenyl-2-propen-1-one (2), rottlerin (3) and 4'-hydroxyrottlerin (4) were isolated. The structure of compound 1 was elucidated by 1D and 2D NMR analyses that included HSQC, HMBC, COSY and ROESY experiments along with the literature comparison. Compounds 1-4 were evaluated for antifungal activity against different human pathogenic yeasts and filamentous fungi. The antiproliferative activity of the compounds was evaluated against Thp-1 cell lines. Compounds 1 and 2 both exhibited IC50 of 8, 4 and 16 μg/mL against Cryptococcus neoformans PRL518, C. neoformans ATCC32045 and Aspergillus fumigatus, respectively. Compound 4, at 100 μg/mL, showed 54% growth inhibition of Thp-1 cell lines. SN - 1478-6427 UR - https://www.unboundmedicine.com/medline/citation/24099509/Antifungal_dimeric_chalcone_derivative_kamalachalcone_E_from_Mallotus_philippinensis_ L2 - https://www.tandfonline.com/doi/full/10.1080/14786419.2013.843178 DB - PRIME DP - Unbound Medicine ER -