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Treatment of hypomagnesemia.
Am J Kidney Dis 2014; 63(4):691-5AJ

Abstract

Serum magnesium concentration is determined by the interplay of intestinal absorption and renal excretion. Hypomagnesemia can occur as a result of insufficient magnesium intake, increased gastrointestinal or renal loss, or redistribution from extracellular to intracellular compartments. A number of drugs are known to cause hypomagnesemia, including proton pump inhibitors (PPIs). We report the case of a patient with symptomatic hypomagnesemia due to short bowel syndrome and PPI therapy. Investigations revealed low 24-hour urinary magnesium excretion and secondary hypocalcemia. PPI treatment was withdrawn and the patient was managed with intravenous and oral magnesium and calcium replacement. This teaching case provides an evidence-based discussion of the treatment of hypomagnesemia.

Authors+Show Affiliations

Department of Endocrinology, Queen Elizabeth Hospital, Edgbaston, Birmingham, United Kingdom.Department of Endocrinology, Queen Elizabeth Hospital, Edgbaston, Birmingham, United Kingdom. Electronic address: neil.gittoes@uhb.nhs.uk.

Pub Type(s)

Case Reports
Journal Article

Language

eng

PubMed ID

24100128

Citation

Ayuk, John, and Neil J L. Gittoes. "Treatment of Hypomagnesemia." American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation, vol. 63, no. 4, 2014, pp. 691-5.
Ayuk J, Gittoes NJ. Treatment of hypomagnesemia. Am J Kidney Dis. 2014;63(4):691-5.
Ayuk, J., & Gittoes, N. J. (2014). Treatment of hypomagnesemia. American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation, 63(4), pp. 691-5. doi:10.1053/j.ajkd.2013.07.025.
Ayuk J, Gittoes NJ. Treatment of Hypomagnesemia. Am J Kidney Dis. 2014;63(4):691-5. PubMed PMID: 24100128.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Treatment of hypomagnesemia. AU - Ayuk,John, AU - Gittoes,Neil J L, Y1 - 2013/10/04/ PY - 2012/11/26/received PY - 2013/07/12/accepted PY - 2013/10/9/entrez PY - 2013/10/9/pubmed PY - 2014/5/20/medline KW - Hypomagnesemia KW - intravenous magnesium sulfate KW - oral magnesium salts KW - proton pump inhibitor KW - treatment SP - 691 EP - 5 JF - American journal of kidney diseases : the official journal of the National Kidney Foundation JO - Am. J. Kidney Dis. VL - 63 IS - 4 N2 - Serum magnesium concentration is determined by the interplay of intestinal absorption and renal excretion. Hypomagnesemia can occur as a result of insufficient magnesium intake, increased gastrointestinal or renal loss, or redistribution from extracellular to intracellular compartments. A number of drugs are known to cause hypomagnesemia, including proton pump inhibitors (PPIs). We report the case of a patient with symptomatic hypomagnesemia due to short bowel syndrome and PPI therapy. Investigations revealed low 24-hour urinary magnesium excretion and secondary hypocalcemia. PPI treatment was withdrawn and the patient was managed with intravenous and oral magnesium and calcium replacement. This teaching case provides an evidence-based discussion of the treatment of hypomagnesemia. SN - 1523-6838 UR - https://www.unboundmedicine.com/medline/citation/24100128/Treatment_of_hypomagnesemia_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0272-6386(13)01181-5 DB - PRIME DP - Unbound Medicine ER -