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Adverse reactions to equine-derived F(ab')2 -antivenin in 54 dogs envenomated by Vipera berus berus.
J Vet Emerg Crit Care (San Antonio). 2013 Sep-Oct; 23(5):532-7.JV

Abstract

OBJECTIVE

To describe the occurrence of acute and delayed adverse reactions following the administration of an equine-derived F(ab')2 -antivenin in dogs with Vipera berus berus envenomation.

DESIGN

Prospective study (2006-2009).

SETTING

Private small animal clinics and university small animal teaching hospital in Norway.

ANIMALS

Fifty-four dogs with Vipera berus berus envenomation treated with F(ab')2 -antivenin.

INTERVENTIONS

Administration of equine-derived antivenin for treatment of Vipera berus berus envenomation in dogs.

MEASUREMENTS AND MAIN RESULTS

Acute adverse reactions to antivenin administration occurred in 4/54 dogs (7%), and facial swelling occurred in 2/54 dogs (4%), sudden respiratory distress in 1 dog, and vomiting occurred in 1 dog. The adverse reactions were self-limiting in 3 of the dogs, while 1 dog was treated with corticosteroids to reduce the facial swelling that occurred during administration of antivenin. No delayed adverse reactions believed to be associated with the antivenin administration were noted.

CONCLUSIONS

An occurrence of adverse effects comparable to the numbers reported in human medicine (10%) should be expected when administering F(ab')2 -antivenin to dogs with Vipera berus berus envenomation. The results are also comparable with rates of adverse effects reported with antivenin administration for crotalid-envenomated dogs. Further research is required to determine whether there is a relationship between adverse and the number of vials administered or repeated use in the same patient.

Authors+Show Affiliations

Departments of Companion Animal Clinical Sciences, Norwegian School of Veterinary Science, Oslo, Norway.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

24102941

Citation

Lund, Heidi S., et al. "Adverse Reactions to Equine-derived F(ab')2 -antivenin in 54 Dogs Envenomated By Vipera Berus Berus." Journal of Veterinary Emergency and Critical Care (San Antonio, Tex. : 2001), vol. 23, no. 5, 2013, pp. 532-7.
Lund HS, Kristiansen V, Eggertsdóttir AV, et al. Adverse reactions to equine-derived F(ab')2 -antivenin in 54 dogs envenomated by Vipera berus berus. J Vet Emerg Crit Care (San Antonio). 2013;23(5):532-7.
Lund, H. S., Kristiansen, V., Eggertsdóttir, A. V., Skancke, E., & Ranheim, B. (2013). Adverse reactions to equine-derived F(ab')2 -antivenin in 54 dogs envenomated by Vipera berus berus. Journal of Veterinary Emergency and Critical Care (San Antonio, Tex. : 2001), 23(5), 532-7. https://doi.org/10.1111/vec.12099
Lund HS, et al. Adverse Reactions to Equine-derived F(ab')2 -antivenin in 54 Dogs Envenomated By Vipera Berus Berus. J Vet Emerg Crit Care (San Antonio). 2013 Sep-Oct;23(5):532-7. PubMed PMID: 24102941.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Adverse reactions to equine-derived F(ab')2 -antivenin in 54 dogs envenomated by Vipera berus berus. AU - Lund,Heidi S, AU - Kristiansen,Veronica, AU - Eggertsdóttir,Anna V, AU - Skancke,Ellen, AU - Ranheim,Birgit, Y1 - 2013/09/19/ PY - 2012/04/20/received PY - 2013/08/04/accepted PY - 2013/10/10/entrez PY - 2013/10/10/pubmed PY - 2014/8/19/medline KW - adverse drug reaction KW - canine KW - viper envenomation SP - 532 EP - 7 JF - Journal of veterinary emergency and critical care (San Antonio, Tex. : 2001) JO - J Vet Emerg Crit Care (San Antonio) VL - 23 IS - 5 N2 - OBJECTIVE: To describe the occurrence of acute and delayed adverse reactions following the administration of an equine-derived F(ab')2 -antivenin in dogs with Vipera berus berus envenomation. DESIGN: Prospective study (2006-2009). SETTING: Private small animal clinics and university small animal teaching hospital in Norway. ANIMALS: Fifty-four dogs with Vipera berus berus envenomation treated with F(ab')2 -antivenin. INTERVENTIONS: Administration of equine-derived antivenin for treatment of Vipera berus berus envenomation in dogs. MEASUREMENTS AND MAIN RESULTS: Acute adverse reactions to antivenin administration occurred in 4/54 dogs (7%), and facial swelling occurred in 2/54 dogs (4%), sudden respiratory distress in 1 dog, and vomiting occurred in 1 dog. The adverse reactions were self-limiting in 3 of the dogs, while 1 dog was treated with corticosteroids to reduce the facial swelling that occurred during administration of antivenin. No delayed adverse reactions believed to be associated with the antivenin administration were noted. CONCLUSIONS: An occurrence of adverse effects comparable to the numbers reported in human medicine (10%) should be expected when administering F(ab')2 -antivenin to dogs with Vipera berus berus envenomation. The results are also comparable with rates of adverse effects reported with antivenin administration for crotalid-envenomated dogs. Further research is required to determine whether there is a relationship between adverse and the number of vials administered or repeated use in the same patient. SN - 1476-4431 UR - https://www.unboundmedicine.com/medline/citation/24102941/Adverse_reactions_to_equine_derived_F_ab'_2__antivenin_in_54_dogs_envenomated_by_Vipera_berus_berus_ L2 - https://doi.org/10.1111/vec.12099 DB - PRIME DP - Unbound Medicine ER -