Tags

Type your tag names separated by a space and hit enter

Depression and serotonin metabolism: rationale for neurotransmitter precursor treatment.
J Clin Psychopharmacol 1985; 5(4):191-206JC

Abstract

The authors review evidence suggesting that some depressed patients have disturbances in serotonin metabolism. Research supporting the serotonin hypothesis includes: cerebrospinal fluid studies; postmortem examination of neurotransmitters, their metabolites, and their receptors; platelet studies; neuropharmacologic data; neuroendocrine perturbations; and reports that serotonin precursor compounds (tryptophan and 5-hydroxytryptophan) may benefit some depressed patients. The authors conclude that better designed studies are needed to test whether serotonin precursor compounds have antidepressant properties.

Authors

No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

2410463

Citation

Byerley, W F., and S C. Risch. "Depression and Serotonin Metabolism: Rationale for Neurotransmitter Precursor Treatment." Journal of Clinical Psychopharmacology, vol. 5, no. 4, 1985, pp. 191-206.
Byerley WF, Risch SC. Depression and serotonin metabolism: rationale for neurotransmitter precursor treatment. J Clin Psychopharmacol. 1985;5(4):191-206.
Byerley, W. F., & Risch, S. C. (1985). Depression and serotonin metabolism: rationale for neurotransmitter precursor treatment. Journal of Clinical Psychopharmacology, 5(4), pp. 191-206.
Byerley WF, Risch SC. Depression and Serotonin Metabolism: Rationale for Neurotransmitter Precursor Treatment. J Clin Psychopharmacol. 1985;5(4):191-206. PubMed PMID: 2410463.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Depression and serotonin metabolism: rationale for neurotransmitter precursor treatment. AU - Byerley,W F, AU - Risch,S C, PY - 1985/8/1/pubmed PY - 1985/8/1/medline PY - 1985/8/1/entrez SP - 191 EP - 206 JF - Journal of clinical psychopharmacology JO - J Clin Psychopharmacol VL - 5 IS - 4 N2 - The authors review evidence suggesting that some depressed patients have disturbances in serotonin metabolism. Research supporting the serotonin hypothesis includes: cerebrospinal fluid studies; postmortem examination of neurotransmitters, their metabolites, and their receptors; platelet studies; neuropharmacologic data; neuroendocrine perturbations; and reports that serotonin precursor compounds (tryptophan and 5-hydroxytryptophan) may benefit some depressed patients. The authors conclude that better designed studies are needed to test whether serotonin precursor compounds have antidepressant properties. SN - 0271-0749 UR - https://www.unboundmedicine.com/medline/citation/2410463/Depression_and_serotonin_metabolism:_rationale_for_neurotransmitter_precursor_treatment_ L2 - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&PAGE=linkout&SEARCH=2410463.ui DB - PRIME DP - Unbound Medicine ER -