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Association between antidepressant prescribing and suicide rates in OECD countries: an ecological study.
Pharmacopsychiatry. 2014 Jan; 47(1):18-21.P

Abstract

INTRODUCTION

We have conducted an ecological study to assess the association between antidepressant prescribing and suicide rates using the Organisation for Economic Co-operation and Development (OECD) health data, making this the largest ecological study in recent times.

METHOD

Data were derived for the years 1995-2008 from the OECD health data set. The residuals for all variables were adjusted for country and year within each country. These were then analysed to identify predictors of suicide rate. Pearson's rank correlation coefficient and linear regression model were employed to assess associations and identify significant predictors of suicide rate.

RESULTS

Suicide rate has significant positive correlations with antidepressant rates (p=0.031) and unemployment (p=0.028). It also has a significant negative correlation with inpatient psychiatric beds (p=0.039). The actual coefficients are less than ±0.16, indicating weak relationships. After adjusting for other variables, the only variable that is a statistically significant predictor of suicide rate is antidepressant prescribing (p=0.005, r²=0.09).

DISCUSSION

Our analysis using this large data set suggests a statistically significant, albeit weak positive, association between antidepressant prescribing and suicide rates.

Authors+Show Affiliations

Department of Psychiatry, Belfast City Hospital, Belfast HSC Trust, U.K.Department of Psychiatry, Belfast City Hospital, Belfast HSC Trust, U.K.Department of Psychiatry, Belfast City Hospital, Belfast HSC Trust, U.K.Northern Ireland Clinical Research Support Centre, Belfast, U.K.Department of Psychiatry, Belfast City Hospital, Belfast HSC Trust, U.K.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

24105079

Citation

Kamat, M A., et al. "Association Between Antidepressant Prescribing and Suicide Rates in OECD Countries: an Ecological Study." Pharmacopsychiatry, vol. 47, no. 1, 2014, pp. 18-21.
Kamat MA, Edgar L, Niblock P, et al. Association between antidepressant prescribing and suicide rates in OECD countries: an ecological study. Pharmacopsychiatry. 2014;47(1):18-21.
Kamat, M. A., Edgar, L., Niblock, P., McDowell, C., & Kelly, C. B. (2014). Association between antidepressant prescribing and suicide rates in OECD countries: an ecological study. Pharmacopsychiatry, 47(1), 18-21. https://doi.org/10.1055/s-0033-1357183
Kamat MA, et al. Association Between Antidepressant Prescribing and Suicide Rates in OECD Countries: an Ecological Study. Pharmacopsychiatry. 2014;47(1):18-21. PubMed PMID: 24105079.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Association between antidepressant prescribing and suicide rates in OECD countries: an ecological study. AU - Kamat,M A, AU - Edgar,L, AU - Niblock,P, AU - McDowell,C, AU - Kelly,C B, Y1 - 2013/10/08/ PY - 2013/10/10/entrez PY - 2013/10/10/pubmed PY - 2014/9/4/medline SP - 18 EP - 21 JF - Pharmacopsychiatry JO - Pharmacopsychiatry VL - 47 IS - 1 N2 - INTRODUCTION: We have conducted an ecological study to assess the association between antidepressant prescribing and suicide rates using the Organisation for Economic Co-operation and Development (OECD) health data, making this the largest ecological study in recent times. METHOD: Data were derived for the years 1995-2008 from the OECD health data set. The residuals for all variables were adjusted for country and year within each country. These were then analysed to identify predictors of suicide rate. Pearson's rank correlation coefficient and linear regression model were employed to assess associations and identify significant predictors of suicide rate. RESULTS: Suicide rate has significant positive correlations with antidepressant rates (p=0.031) and unemployment (p=0.028). It also has a significant negative correlation with inpatient psychiatric beds (p=0.039). The actual coefficients are less than ±0.16, indicating weak relationships. After adjusting for other variables, the only variable that is a statistically significant predictor of suicide rate is antidepressant prescribing (p=0.005, r²=0.09). DISCUSSION: Our analysis using this large data set suggests a statistically significant, albeit weak positive, association between antidepressant prescribing and suicide rates. SN - 1439-0795 UR - https://www.unboundmedicine.com/medline/citation/24105079/Association_between_antidepressant_prescribing_and_suicide_rates_in_OECD_countries:_an_ecological_study_ L2 - http://www.thieme-connect.com/DOI/DOI?10.1055/s-0033-1357183 DB - PRIME DP - Unbound Medicine ER -