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Female neuregulin 1 heterozygous mice require repeated exposure to Δ⁹-tetrahydrocannabinol to alter sensorimotor gating function.
Pharmacopsychiatry. 2013 Nov; 46(7):286-91.P

Abstract

INTRODUCTION

The schizophrenia susceptibility gene neuregulin 1 (NRG1) confers vulnerability to the neurobehavioural eff ects of cannabinoids differently across sexes. Male but not female Nrg1 heterozygous (HET) mice display facilitation of prepulse inhibition (PPI) to acute Δ⁹-tetrahydrocannabinol (THC) exposure compared to WT controls. We aim to observe whether repeated administration of THC may overcome the acute insensitivity of female Nrg1 HET mice to THC exposure.

METHODS

Female Nrg1 HET mice and WT controls were administered THC daily for 21 days, with PPI and anxiety-related behaviour in the light-dark test (LD) examined on the fi rst and last day of treatment and 21 days after cessation of dosing.

RESULTS

Following repeated, but not acute THC exposure, female Nrg1 HET mice displayed THC-induced facilitation of PPI which was not observed in WT mice treated with THC. There were no residual eff ects of THC on PPI in either genotype when assessed 21 days following the final THC dose. An anxiogenic response to THC was evident following repeated, but not acute, administration in the LD test in both genotypes.

DISCUSSION

These findings show that the acute insensitivity of female Nrg1 HET mice to THC-induced PPI facilitation may be overcome following repeated THC exposure.

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Authors+Show Affiliations

Spencer JR
Discipline of Pharmacology, University of Sydney, Sydney, NSW, Australia.
Chohan TW
No affiliation info available
Karl T
No affiliation info available
Arnold JC
No affiliation info available

MeSH

AnimalsAnxietyDronabinolFemaleGenotypeHeterozygoteMiceNeuregulin-1Sensory Gating

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

24105081

Citation

Spencer, J R., et al. "Female Neuregulin 1 Heterozygous Mice Require Repeated Exposure to Δ⁹-tetrahydrocannabinol to Alter Sensorimotor Gating Function." Pharmacopsychiatry, vol. 46, no. 7, 2013, pp. 286-91.
Spencer JR, Chohan TW, Karl T, et al. Female neuregulin 1 heterozygous mice require repeated exposure to Δ⁹-tetrahydrocannabinol to alter sensorimotor gating function. Pharmacopsychiatry. 2013;46(7):286-91.
Spencer, J. R., Chohan, T. W., Karl, T., & Arnold, J. C. (2013). Female neuregulin 1 heterozygous mice require repeated exposure to Δ⁹-tetrahydrocannabinol to alter sensorimotor gating function. Pharmacopsychiatry, 46(7), 286-91. https://doi.org/10.1055/s-0033-1355390
Spencer JR, et al. Female Neuregulin 1 Heterozygous Mice Require Repeated Exposure to Δ⁹-tetrahydrocannabinol to Alter Sensorimotor Gating Function. Pharmacopsychiatry. 2013;46(7):286-91. PubMed PMID: 24105081.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Female neuregulin 1 heterozygous mice require repeated exposure to Δ⁹-tetrahydrocannabinol to alter sensorimotor gating function. AU - Spencer,J R, AU - Chohan,T W, AU - Karl,T, AU - Arnold,J C, Y1 - 2013/10/08/ PY - 2013/10/10/entrez PY - 2013/10/10/pubmed PY - 2014/11/16/medline SP - 286 EP - 91 JF - Pharmacopsychiatry JO - Pharmacopsychiatry VL - 46 IS - 7 N2 - INTRODUCTION: The schizophrenia susceptibility gene neuregulin 1 (NRG1) confers vulnerability to the neurobehavioural eff ects of cannabinoids differently across sexes. Male but not female Nrg1 heterozygous (HET) mice display facilitation of prepulse inhibition (PPI) to acute Δ⁹-tetrahydrocannabinol (THC) exposure compared to WT controls. We aim to observe whether repeated administration of THC may overcome the acute insensitivity of female Nrg1 HET mice to THC exposure. METHODS: Female Nrg1 HET mice and WT controls were administered THC daily for 21 days, with PPI and anxiety-related behaviour in the light-dark test (LD) examined on the fi rst and last day of treatment and 21 days after cessation of dosing. RESULTS: Following repeated, but not acute THC exposure, female Nrg1 HET mice displayed THC-induced facilitation of PPI which was not observed in WT mice treated with THC. There were no residual eff ects of THC on PPI in either genotype when assessed 21 days following the final THC dose. An anxiogenic response to THC was evident following repeated, but not acute, administration in the LD test in both genotypes. DISCUSSION: These findings show that the acute insensitivity of female Nrg1 HET mice to THC-induced PPI facilitation may be overcome following repeated THC exposure. SN - 1439-0795 UR - https://www.unboundmedicine.com/medline/citation/24105081/Female_neuregulin_1_heterozygous_mice_require_repeated_exposure_to_�����_tetrahydrocannabinol_to_alter_sensorimotor_gating_function_ L2 - http://www.thieme-connect.com/DOI/DOI?10.1055/s-0033-1355390 DB - PRIME DP - Unbound Medicine ER -