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Helicobacter pylori infection and esophageal cancer risk: an updated meta-analysis.
World J Gastroenterol. 2013 Sep 28; 19(36):6098-107.WJ

Abstract

AIM

To clarify the association between Helicobacter pylori (H. pylori) infection and the risk of esophageal carcinoma through a meta-analysis of published data.

METHODS

Studies which reported the association between H. pylori infection and esophageal cancer published up to June 2013 were included. The odds ratios (ORs) and corresponding 95%CIs of H. pylori infection on esophageal cancer with respect to health control groups were evaluated. Data were extracted independently by two investigators and discrepancies were resolved by discussion with a third investigator. The statistical software, STATA (version 12.0), was applied to investigate heterogeneity among individual studies and to summarize the studies. A meta-analysis was performed using a fixed-effect or random-effect method, depending on the absence or presence of significant heterogeneity.

RESULTS

No significant association between H. pylori infection and esophageal squamous cell carcinoma (ESCC) risk was found in the pooled overall population (OR = 0.97, 95%CI: 0.76-1.24). However, significant associations between H. pylori infection and ESCC risk were found in Eastern subjects (OR = 0.66, 95%CI: 0.43-0.89). Similarly, cytotoxin-associated gene-A (CagA) positive strains of infection may decrease the risk of ESCC in Eastern subjects (OR = 0.77, 95%CI: 0.65-0.92), however, these associations were not statistically significant in Western subjects (OR = 1.26, 95%CI: 0.97-1.63). For esophageal adenocarcinoma (EAC) the summary OR for H. pylori infection and CagA positive strains of infection were 0.59 (95%CI: 0.51-0.68) and 0.56 (95%CI: 0.45-0.70), respectively.

CONCLUSION

H. pylori infection is associated with a decreased risk of ESCC in Eastern populations and a decreased risk of EAC in the overall population.

Authors+Show Affiliations

Fa-Jun Xie, Yi-Ping Zhang, Lan Shao, Xin-Min Yu, Department of Medical Oncology, Zhejiang Cancer Hospital, Hangzhou 310022, Zhejiang Province, China.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Meta-Analysis
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

24106412

Citation

Xie, Fa-Jun, et al. "Helicobacter Pylori Infection and Esophageal Cancer Risk: an Updated Meta-analysis." World Journal of Gastroenterology, vol. 19, no. 36, 2013, pp. 6098-107.
Xie FJ, Zhang YP, Zheng QQ, et al. Helicobacter pylori infection and esophageal cancer risk: an updated meta-analysis. World J Gastroenterol. 2013;19(36):6098-107.
Xie, F. J., Zhang, Y. P., Zheng, Q. Q., Jin, H. C., Wang, F. L., Chen, M., Shao, L., Zou, D. H., Yu, X. M., & Mao, W. M. (2013). Helicobacter pylori infection and esophageal cancer risk: an updated meta-analysis. World Journal of Gastroenterology, 19(36), 6098-107. https://doi.org/10.3748/wjg.v19.i36.6098
Xie FJ, et al. Helicobacter Pylori Infection and Esophageal Cancer Risk: an Updated Meta-analysis. World J Gastroenterol. 2013 Sep 28;19(36):6098-107. PubMed PMID: 24106412.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Helicobacter pylori infection and esophageal cancer risk: an updated meta-analysis. AU - Xie,Fa-Jun, AU - Zhang,Yi-Ping, AU - Zheng,Qiu-Qing, AU - Jin,Hong-Chuan, AU - Wang,Fa-Liang, AU - Chen,Ming, AU - Shao,Lan, AU - Zou,De-Hong, AU - Yu,Xin-Min, AU - Mao,Wei-Min, PY - 2013/06/14/received PY - 2013/07/29/revised PY - 2013/08/12/accepted PY - 2013/10/10/entrez PY - 2013/10/10/pubmed PY - 2014/3/14/medline KW - Cancer risk KW - Esophageal carcinoma KW - Helicobacter pylori KW - Meta-analysis SP - 6098 EP - 107 JF - World journal of gastroenterology JO - World J Gastroenterol VL - 19 IS - 36 N2 - AIM: To clarify the association between Helicobacter pylori (H. pylori) infection and the risk of esophageal carcinoma through a meta-analysis of published data. METHODS: Studies which reported the association between H. pylori infection and esophageal cancer published up to June 2013 were included. The odds ratios (ORs) and corresponding 95%CIs of H. pylori infection on esophageal cancer with respect to health control groups were evaluated. Data were extracted independently by two investigators and discrepancies were resolved by discussion with a third investigator. The statistical software, STATA (version 12.0), was applied to investigate heterogeneity among individual studies and to summarize the studies. A meta-analysis was performed using a fixed-effect or random-effect method, depending on the absence or presence of significant heterogeneity. RESULTS: No significant association between H. pylori infection and esophageal squamous cell carcinoma (ESCC) risk was found in the pooled overall population (OR = 0.97, 95%CI: 0.76-1.24). However, significant associations between H. pylori infection and ESCC risk were found in Eastern subjects (OR = 0.66, 95%CI: 0.43-0.89). Similarly, cytotoxin-associated gene-A (CagA) positive strains of infection may decrease the risk of ESCC in Eastern subjects (OR = 0.77, 95%CI: 0.65-0.92), however, these associations were not statistically significant in Western subjects (OR = 1.26, 95%CI: 0.97-1.63). For esophageal adenocarcinoma (EAC) the summary OR for H. pylori infection and CagA positive strains of infection were 0.59 (95%CI: 0.51-0.68) and 0.56 (95%CI: 0.45-0.70), respectively. CONCLUSION: H. pylori infection is associated with a decreased risk of ESCC in Eastern populations and a decreased risk of EAC in the overall population. SN - 2219-2840 UR - https://www.unboundmedicine.com/medline/citation/24106412/Helicobacter_pylori_infection_and_esophageal_cancer_risk:_an_updated_meta_analysis_ L2 - https://www.wjgnet.com/1007-9327/full/v19/i36/6098.htm DB - PRIME DP - Unbound Medicine ER -