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Study of corneal copper deposits in Wilson's disease by in vivo confocal microscopy.
Ophthalmologica 2014; 231(3):147-52O

Abstract

PURPOSE

To study corneal copper deposits in Wilson's disease (WD) patients by traditional biomicroscopy and in vivo laser scanning confocal microscopy (LSCM).

METHODS

Twenty WD patients and 20 matched controls underwent an ophthalmic examination in one eye randomly chosen, including slit lamp biomicroscopy with Goldmann's three-mirror contact lens examination and LSCM, in order to evaluate copper deposits in the peripheral cornea.

RESULTS

No control subjects had corneal changes at both traditional biomicroscopy and LSCM. Only 25% of WD patients had detectable slit lamp changes, compared with 75% with LSCM examination. All cases detected by slit lamp were detected by LSCM. A significant correlation (p < 0.01) was found between deposit intensity at LSCM and daily urinary copper excretion.

CONCLUSION

LSCM could detect copper deposition in WD corneas in more patients than traditional examination; it may therefore provide important information in cases of suspected WD diagnosis.

Authors+Show Affiliations

Università degli Studi di Milano, U.O. Oculistica, Dipartimento di Medicina, Chirurgia e Odontoiatria, Azienda Ospedaliera San Paolo, Milano, Italia.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

24107714

Citation

Ceresara, Gaia, et al. "Study of Corneal Copper Deposits in Wilson's Disease By in Vivo Confocal Microscopy." Ophthalmologica. Journal International D'ophtalmologie. International Journal of Ophthalmology. Zeitschrift Fur Augenheilkunde, vol. 231, no. 3, 2014, pp. 147-52.
Ceresara G, Fogagnolo P, Zuin M, et al. Study of corneal copper deposits in Wilson's disease by in vivo confocal microscopy. Ophthalmologica. 2014;231(3):147-52.
Ceresara, G., Fogagnolo, P., Zuin, M., Zatelli, S., Bovet, J., & Rossetti, L. (2014). Study of corneal copper deposits in Wilson's disease by in vivo confocal microscopy. Ophthalmologica. Journal International D'ophtalmologie. International Journal of Ophthalmology. Zeitschrift Fur Augenheilkunde, 231(3), pp. 147-52. doi:10.1159/000355090.
Ceresara G, et al. Study of Corneal Copper Deposits in Wilson's Disease By in Vivo Confocal Microscopy. Ophthalmologica. 2014;231(3):147-52. PubMed PMID: 24107714.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Study of corneal copper deposits in Wilson's disease by in vivo confocal microscopy. AU - Ceresara,Gaia, AU - Fogagnolo,Paolo, AU - Zuin,Massimo, AU - Zatelli,Stefania, AU - Bovet,Jerôme, AU - Rossetti,Luca, Y1 - 2013/10/02/ PY - 2013/02/05/received PY - 2013/08/03/accepted PY - 2013/10/11/entrez PY - 2013/10/11/pubmed PY - 2014/10/23/medline SP - 147 EP - 52 JF - Ophthalmologica. Journal international d'ophtalmologie. International journal of ophthalmology. Zeitschrift fur Augenheilkunde JO - Ophthalmologica VL - 231 IS - 3 N2 - PURPOSE: To study corneal copper deposits in Wilson's disease (WD) patients by traditional biomicroscopy and in vivo laser scanning confocal microscopy (LSCM). METHODS: Twenty WD patients and 20 matched controls underwent an ophthalmic examination in one eye randomly chosen, including slit lamp biomicroscopy with Goldmann's three-mirror contact lens examination and LSCM, in order to evaluate copper deposits in the peripheral cornea. RESULTS: No control subjects had corneal changes at both traditional biomicroscopy and LSCM. Only 25% of WD patients had detectable slit lamp changes, compared with 75% with LSCM examination. All cases detected by slit lamp were detected by LSCM. A significant correlation (p < 0.01) was found between deposit intensity at LSCM and daily urinary copper excretion. CONCLUSION: LSCM could detect copper deposition in WD corneas in more patients than traditional examination; it may therefore provide important information in cases of suspected WD diagnosis. SN - 1423-0267 UR - https://www.unboundmedicine.com/medline/citation/24107714/Study_of_corneal_copper_deposits_in_Wilson's_disease_by_in_vivo_confocal_microscopy_ L2 - https://www.karger.com?DOI=10.1159/000355090 DB - PRIME DP - Unbound Medicine ER -