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Specific splice variants are associated with Parkinson's disease.
Mov Disord. 2013 Oct; 28(12):1724-7.MD

Abstract

BACKGROUND

Diagnosis of Parkinson's disease (PD) currently relies on assessment of motor symptoms. Recently, sensitive, specific, and readily available splice variant-specific biomarkers were identified in peripheral blood from participants in the Diagnostic and Prognostic Biomarkers in Parkinson Disease study.

METHODS

Here we test for an association between candidate splice variant biomarkers and PD in blood of an independent population of cases and controls nested in the Harvard NeuroDiscovery Center Biomarker Study.

RESULTS

Expression of 7 out of 13 candidate biomarkers was dysregulated in whole cellular blood of patients with PD.

CONCLUSIONS

These results support the view that differential expression of a subset of splice-variant markers in blood is associated with PD. Further evaluation in untreated, de novo patients and at-risk subjects is warranted.

Authors+Show Affiliations

Department of Cellular and Molecular Pharmacology, The Chicago Medical School, Rosalind Franklin University of Medicine and Science, North Chicago, Illinois, USA.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.

Language

eng

PubMed ID

24108702

Citation

Santiago, Jose A., et al. "Specific Splice Variants Are Associated With Parkinson's Disease." Movement Disorders : Official Journal of the Movement Disorder Society, vol. 28, no. 12, 2013, pp. 1724-7.
Santiago JA, Scherzer CR, Harvard Biomarker Study, et al. Specific splice variants are associated with Parkinson's disease. Mov Disord. 2013;28(12):1724-7.
Santiago, J. A., Scherzer, C. R., & Potashkin, J. A. (2013). Specific splice variants are associated with Parkinson's disease. Movement Disorders : Official Journal of the Movement Disorder Society, 28(12), 1724-7. https://doi.org/10.1002/mds.25635
Santiago JA, et al. Specific Splice Variants Are Associated With Parkinson's Disease. Mov Disord. 2013;28(12):1724-7. PubMed PMID: 24108702.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Specific splice variants are associated with Parkinson's disease. AU - Santiago,Jose A, AU - Scherzer,Clemens R, AU - ,, AU - Potashkin,Judith A, Y1 - 2013/09/20/ PY - 2013/03/22/received PY - 2013/05/14/revised PY - 2013/07/14/accepted PY - 2013/10/11/entrez PY - 2013/10/11/pubmed PY - 2014/6/21/medline KW - Parkinson's disease KW - biomarker KW - gene expression KW - neurodegeneration KW - splicing SP - 1724 EP - 7 JF - Movement disorders : official journal of the Movement Disorder Society JO - Mov Disord VL - 28 IS - 12 N2 - BACKGROUND: Diagnosis of Parkinson's disease (PD) currently relies on assessment of motor symptoms. Recently, sensitive, specific, and readily available splice variant-specific biomarkers were identified in peripheral blood from participants in the Diagnostic and Prognostic Biomarkers in Parkinson Disease study. METHODS: Here we test for an association between candidate splice variant biomarkers and PD in blood of an independent population of cases and controls nested in the Harvard NeuroDiscovery Center Biomarker Study. RESULTS: Expression of 7 out of 13 candidate biomarkers was dysregulated in whole cellular blood of patients with PD. CONCLUSIONS: These results support the view that differential expression of a subset of splice-variant markers in blood is associated with PD. Further evaluation in untreated, de novo patients and at-risk subjects is warranted. SN - 1531-8257 UR - https://www.unboundmedicine.com/medline/citation/24108702/Specific_splice_variants_are_associated_with_Parkinson's_disease_ L2 - https://doi.org/10.1002/mds.25635 DB - PRIME DP - Unbound Medicine ER -