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Dietary patterns and breast cancer risk in the California Teachers Study cohort.
Am J Clin Nutr. 2013 Dec; 98(6):1524-32.AJ

Abstract

BACKGROUND

Evidence that diet is associated with breast cancer risk is inconsistent. Most studies have examined risks associated with specific foods and nutrients, rather than measures of overall diet.

OBJECTIVE

This study aimed to evaluate dietary patterns and their relation to breast cancer risk in a large cohort of women.

DESIGN

Data from 91,779 women in the California Teachers Study cohort were analyzed, including data from 4140 women with a diagnosis of invasive breast cancer made between 1995 and 2009. Five predominant dietary patterns were identified by using principal components factor analysis: a plant-based diet, high in fruit and vegetables; a high-protein, high-fat diet, high in meats, eggs, fried foods, and high-fat condiments; a high-carbohydrate diet, high in convenience foods, pasta, and bread products; an ethnic diet, high in legumes, soy-based foods, rice, and dark-green leafy vegetables; and a salad and wine diet, high in lettuce, fish, wine, low-fat salad dressing, and coffee and tea.

RESULTS

The plant-based pattern was associated with a reduction in breast cancer risk (RR: 0.85; 95% CI: 0.76, 0.95 for the highest compared with the lowest consumption quintile; P-trend = 0.003); risk reduction was greater for estrogen receptor-negative progesterone receptor-negative (ER-PR-) tumors (RR: 0.66; 95% CI: 0.48, 0.91; P-trend = 0.03). The salad and wine pattern was associated with an increased risk of estrogen receptor-positive progesterone receptor-positive tumors (RR: 1.29; 95% CI: 1.12, 1.49); this effect was only slightly attenuated after adjustment for alcohol consumption.

CONCLUSION

The finding that greater consumption of a plant-based dietary pattern is associated with a reduced breast cancer risk, particularly for ER-PR- tumors, offers a potential avenue for prevention.

Authors+Show Affiliations

From Cancer Epidemiology, Mailman School of Public Health, Columbia University, New York, NY (LBL); the Cancer Prevention Institute of California, Fremont, CA (AJC, CAC, and PLH-R); the Department of Health Research and Policy, Stanford University School of Medicine, Stanford, CA (CAC and PLH-R); the Division of Cancer Etiology, Department of Population Sciences, Beckman Research Institute, City of Hope, Duarte, CA (LB); the Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA (DOS and GU); the Cancer Registry of Norway, Oslo, Norway (GU); and the Department of Nutrition, University of Oslo, Oslo, Norway (GU).No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

24108781

Citation

Link, Lilli B., et al. "Dietary Patterns and Breast Cancer Risk in the California Teachers Study Cohort." The American Journal of Clinical Nutrition, vol. 98, no. 6, 2013, pp. 1524-32.
Link LB, Canchola AJ, Bernstein L, et al. Dietary patterns and breast cancer risk in the California Teachers Study cohort. Am J Clin Nutr. 2013;98(6):1524-32.
Link, L. B., Canchola, A. J., Bernstein, L., Clarke, C. A., Stram, D. O., Ursin, G., & Horn-Ross, P. L. (2013). Dietary patterns and breast cancer risk in the California Teachers Study cohort. The American Journal of Clinical Nutrition, 98(6), 1524-32. https://doi.org/10.3945/ajcn.113.061184
Link LB, et al. Dietary Patterns and Breast Cancer Risk in the California Teachers Study Cohort. Am J Clin Nutr. 2013;98(6):1524-32. PubMed PMID: 24108781.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Dietary patterns and breast cancer risk in the California Teachers Study cohort. AU - Link,Lilli B, AU - Canchola,Alison J, AU - Bernstein,Leslie, AU - Clarke,Christina A, AU - Stram,Daniel O, AU - Ursin,Giske, AU - Horn-Ross,Pamela L, Y1 - 2013/10/09/ PY - 2013/10/11/entrez PY - 2013/10/11/pubmed PY - 2014/4/8/medline SP - 1524 EP - 32 JF - The American journal of clinical nutrition JO - Am J Clin Nutr VL - 98 IS - 6 N2 - BACKGROUND: Evidence that diet is associated with breast cancer risk is inconsistent. Most studies have examined risks associated with specific foods and nutrients, rather than measures of overall diet. OBJECTIVE: This study aimed to evaluate dietary patterns and their relation to breast cancer risk in a large cohort of women. DESIGN: Data from 91,779 women in the California Teachers Study cohort were analyzed, including data from 4140 women with a diagnosis of invasive breast cancer made between 1995 and 2009. Five predominant dietary patterns were identified by using principal components factor analysis: a plant-based diet, high in fruit and vegetables; a high-protein, high-fat diet, high in meats, eggs, fried foods, and high-fat condiments; a high-carbohydrate diet, high in convenience foods, pasta, and bread products; an ethnic diet, high in legumes, soy-based foods, rice, and dark-green leafy vegetables; and a salad and wine diet, high in lettuce, fish, wine, low-fat salad dressing, and coffee and tea. RESULTS: The plant-based pattern was associated with a reduction in breast cancer risk (RR: 0.85; 95% CI: 0.76, 0.95 for the highest compared with the lowest consumption quintile; P-trend = 0.003); risk reduction was greater for estrogen receptor-negative progesterone receptor-negative (ER-PR-) tumors (RR: 0.66; 95% CI: 0.48, 0.91; P-trend = 0.03). The salad and wine pattern was associated with an increased risk of estrogen receptor-positive progesterone receptor-positive tumors (RR: 1.29; 95% CI: 1.12, 1.49); this effect was only slightly attenuated after adjustment for alcohol consumption. CONCLUSION: The finding that greater consumption of a plant-based dietary pattern is associated with a reduced breast cancer risk, particularly for ER-PR- tumors, offers a potential avenue for prevention. SN - 1938-3207 UR - https://www.unboundmedicine.com/medline/citation/24108781/Dietary_patterns_and_breast_cancer_risk_in_the_California_Teachers_Study_cohort_ L2 - https://academic.oup.com/ajcn/article-lookup/doi/10.3945/ajcn.113.061184 DB - PRIME DP - Unbound Medicine ER -