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Effects of the motor cortical quadripulse transcranial magnetic stimulation (QPS) on the contralateral motor cortex and interhemispheric interactions.
J Neurophysiol. 2014 Jan; 111(1):26-35.JN

Abstract

Corpus callosum connects the bilateral primary motor cortices (M1s) and plays an important role in motor control. Using the paired-pulse transcranial magnetic stimulation (TMS) paradigm, we can measure interhemispheric inhibition (IHI) and interhemispheric facilitation (IHF) as indexes of the interhemispheric interactions in humans. We investigated how quadripulse transcranial magnetic stimulation (QPS), one form of repetitive TMS (rTMS), on M1 affects the contralateral M1 and the interhemispheric interactions. QPS is able to induce bidirectional plastic changes in M1 depending on the interstimulus intervals (ISIs) of TMS pulses: long-term potentiation (LTP)-like effect by QPS-5 protocol, and long-term depression-like effect by QPS-50, whose numbers indicate the ISI (ms). Twelve healthy subjects were enrolled. We applied QPS over the left M1 and recorded several parameters before and 30 min after QPS. QPS-5, which increased motor-evoked potentials (MEPs) induced by left M1 activation, also increased MEPs induced by right M1 activation. Meanwhile, QPS-50, which decreased MEPs elicited by left M1 activation, did not induce any significant changes in MEPs elicited by right M1 activation. None of the resting motor threshold, active motor threshold, short-interval intracortical inhibition, long-interval intracortical inhibition, intracortical facilitation, and short-interval intracortical inhibition in right M1 were affected by QPS. IHI and IHF from left to right M1 significantly increased after left M1 QPS-5. The degree of left first dorsal interosseous MEP amplitude change by QPS-5 significantly correlated with the degree of IHF change. We suppose that the LTP-like effect on the contralateral M1 may be produced by some interhemispheric interactions through the corpus callosum.

Authors+Show Affiliations

Department of Neurology, Division of Neuroscience, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan; and.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

24108795

Citation

Tsutsumi, Ryosuke, et al. "Effects of the Motor Cortical Quadripulse Transcranial Magnetic Stimulation (QPS) On the Contralateral Motor Cortex and Interhemispheric Interactions." Journal of Neurophysiology, vol. 111, no. 1, 2014, pp. 26-35.
Tsutsumi R, Hanajima R, Terao Y, et al. Effects of the motor cortical quadripulse transcranial magnetic stimulation (QPS) on the contralateral motor cortex and interhemispheric interactions. J Neurophysiol. 2014;111(1):26-35.
Tsutsumi, R., Hanajima, R., Terao, Y., Shirota, Y., Ohminami, S., Shimizu, T., Tanaka, N., & Ugawa, Y. (2014). Effects of the motor cortical quadripulse transcranial magnetic stimulation (QPS) on the contralateral motor cortex and interhemispheric interactions. Journal of Neurophysiology, 111(1), 26-35. https://doi.org/10.1152/jn.00515.2013
Tsutsumi R, et al. Effects of the Motor Cortical Quadripulse Transcranial Magnetic Stimulation (QPS) On the Contralateral Motor Cortex and Interhemispheric Interactions. J Neurophysiol. 2014;111(1):26-35. PubMed PMID: 24108795.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effects of the motor cortical quadripulse transcranial magnetic stimulation (QPS) on the contralateral motor cortex and interhemispheric interactions. AU - Tsutsumi,Ryosuke, AU - Hanajima,Ritsuko, AU - Terao,Yasuo, AU - Shirota,Yuichiro, AU - Ohminami,Shinya, AU - Shimizu,Takahiro, AU - Tanaka,Nobuyuki, AU - Ugawa,Yoshikazu, Y1 - 2013/10/09/ PY - 2013/10/11/entrez PY - 2013/10/11/pubmed PY - 2014/8/12/medline KW - corpus callosum KW - interhemispheric facilitation KW - interhemispheric inhibition KW - plasticity KW - repetitive transcranial magnetic stimulation SP - 26 EP - 35 JF - Journal of neurophysiology JO - J. Neurophysiol. VL - 111 IS - 1 N2 - Corpus callosum connects the bilateral primary motor cortices (M1s) and plays an important role in motor control. Using the paired-pulse transcranial magnetic stimulation (TMS) paradigm, we can measure interhemispheric inhibition (IHI) and interhemispheric facilitation (IHF) as indexes of the interhemispheric interactions in humans. We investigated how quadripulse transcranial magnetic stimulation (QPS), one form of repetitive TMS (rTMS), on M1 affects the contralateral M1 and the interhemispheric interactions. QPS is able to induce bidirectional plastic changes in M1 depending on the interstimulus intervals (ISIs) of TMS pulses: long-term potentiation (LTP)-like effect by QPS-5 protocol, and long-term depression-like effect by QPS-50, whose numbers indicate the ISI (ms). Twelve healthy subjects were enrolled. We applied QPS over the left M1 and recorded several parameters before and 30 min after QPS. QPS-5, which increased motor-evoked potentials (MEPs) induced by left M1 activation, also increased MEPs induced by right M1 activation. Meanwhile, QPS-50, which decreased MEPs elicited by left M1 activation, did not induce any significant changes in MEPs elicited by right M1 activation. None of the resting motor threshold, active motor threshold, short-interval intracortical inhibition, long-interval intracortical inhibition, intracortical facilitation, and short-interval intracortical inhibition in right M1 were affected by QPS. IHI and IHF from left to right M1 significantly increased after left M1 QPS-5. The degree of left first dorsal interosseous MEP amplitude change by QPS-5 significantly correlated with the degree of IHF change. We suppose that the LTP-like effect on the contralateral M1 may be produced by some interhemispheric interactions through the corpus callosum. SN - 1522-1598 UR - https://www.unboundmedicine.com/medline/citation/24108795/Effects_of_the_motor_cortical_quadripulse_transcranial_magnetic_stimulation__QPS__on_the_contralateral_motor_cortex_and_interhemispheric_interactions_ L2 - http://www.physiology.org/doi/full/10.1152/jn.00515.2013?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -