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Mood disorders after traumatic brain injury in adolescents and young adults: a nationwide population-based cohort study.
J Pediatr 2014; 164(1):136-141.e1JPed

Abstract

OBJECTIVE

To delineate the relationship between traumatic brain injury (TBI) and mood disorders from population-based data in Taiwan.

STUDY DESIGN

This prospectively followed cohort study involved a subset of the National Health Insurance Research Database containing complete inpatient and outpatient data of 1 million randomly drawn beneficiaries. We included 10- to 24-year-old patients (n = 15,203) receiving the diagnosis of TBI in ambulatory visits or hospitalization from 2000-2004 and their age- and sex-matched comparison insureds using health service in the same year (n = 76,015). Diagnosis of mood disorders was recorded within 5 years after the traumatic event or index use of health service. Baseline demographics, clinical characteristics, and premorbid psychiatric conditions were compared using χ(2) analysis. Increased risk during the 5-year follow-up period was represented by crude and adjusted hazard ratios with 95% CI using a Cox proportional hazard regression.

RESULTS

A total of 451/15,203 patients with TBI (2.97%) received a diagnosis of mood disorders in the 5-year follow-up period compared with 1153/97,445 individuals (1.52%) without antecedent TBI. After adjusting for select premorbid comorbidities, TBI remained a significant predisposing factor with a 1.96-fold (95% CI 1.74-2.22) increase in risk of mood disorders.

CONCLUSIONS

Our findings show a higher likelihood of manifesting mood disorders in adolescents and young adults who sustained a prior TBI. Health professionals should carefully monitor both the physical and psychological impacts of head trauma.

Authors+Show Affiliations

Institute of Clinical Medicine, National Cheng Kung University, Tainan, Taiwan; Department of Pediatrics, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan.Institute of Clinical Medicine, National Cheng Kung University, Tainan, Taiwan.Institute of Clinical Medicine, National Cheng Kung University, Tainan, Taiwan; Department of Neurosurgery, E-Da Hospital, I-Shou University, Kaohsiung, Taiwan.Institute of Clinical Medicine, National Cheng Kung University, Tainan, Taiwan; Department of Neurology, National Cheng Kung University Hospital, Tainan, Taiwan.Institute of Clinical Medicine, National Cheng Kung University, Tainan, Taiwan; Department of Neurology, Chi Mei Medical Center, Liouying, Tainan, Taiwan.Institute of Clinical Medicine, National Cheng Kung University, Tainan, Taiwan; Department of Neurology, Yuan's General Hospital, Kaohsiung, Taiwan.Institute of Clinical Medicine, National Cheng Kung University, Tainan, Taiwan. Electronic address: shlin922@mail.ncku.edu.tw.

Pub Type(s)

Comparative Study
Journal Article
Multicenter Study
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

24112864

Citation

Tsai, Meng-Che, et al. "Mood Disorders After Traumatic Brain Injury in Adolescents and Young Adults: a Nationwide Population-based Cohort Study." The Journal of Pediatrics, vol. 164, no. 1, 2014, pp. 136-141.e1.
Tsai MC, Tsai KJ, Wang HK, et al. Mood disorders after traumatic brain injury in adolescents and young adults: a nationwide population-based cohort study. J Pediatr. 2014;164(1):136-141.e1.
Tsai, M. C., Tsai, K. J., Wang, H. K., Sung, P. S., Wu, M. H., Hung, K. W., & Lin, S. H. (2014). Mood disorders after traumatic brain injury in adolescents and young adults: a nationwide population-based cohort study. The Journal of Pediatrics, 164(1), pp. 136-141.e1. doi:10.1016/j.jpeds.2013.08.042.
Tsai MC, et al. Mood Disorders After Traumatic Brain Injury in Adolescents and Young Adults: a Nationwide Population-based Cohort Study. J Pediatr. 2014;164(1):136-141.e1. PubMed PMID: 24112864.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Mood disorders after traumatic brain injury in adolescents and young adults: a nationwide population-based cohort study. AU - Tsai,Meng-Che, AU - Tsai,Kuen-Jer, AU - Wang,Hao-Kuang, AU - Sung,Pi-Shan, AU - Wu,Ming-Hsiu, AU - Hung,Kuo-Wei, AU - Lin,Sheng-Hsiang, Y1 - 2013/10/08/ PY - 2013/02/08/received PY - 2013/07/02/revised PY - 2013/08/21/accepted PY - 2013/10/12/entrez PY - 2013/10/12/pubmed PY - 2014/2/19/medline KW - EC KW - Enrollee category KW - HR KW - Hazard ratio KW - ICD-9-CM KW - International Classification of Diseases, Ninth Revision, Clinically Modified KW - NHI KW - National Health Insurance KW - TBI KW - Traumatic brain injury SP - 136 EP - 141.e1 JF - The Journal of pediatrics JO - J. Pediatr. VL - 164 IS - 1 N2 - OBJECTIVE: To delineate the relationship between traumatic brain injury (TBI) and mood disorders from population-based data in Taiwan. STUDY DESIGN: This prospectively followed cohort study involved a subset of the National Health Insurance Research Database containing complete inpatient and outpatient data of 1 million randomly drawn beneficiaries. We included 10- to 24-year-old patients (n = 15,203) receiving the diagnosis of TBI in ambulatory visits or hospitalization from 2000-2004 and their age- and sex-matched comparison insureds using health service in the same year (n = 76,015). Diagnosis of mood disorders was recorded within 5 years after the traumatic event or index use of health service. Baseline demographics, clinical characteristics, and premorbid psychiatric conditions were compared using χ(2) analysis. Increased risk during the 5-year follow-up period was represented by crude and adjusted hazard ratios with 95% CI using a Cox proportional hazard regression. RESULTS: A total of 451/15,203 patients with TBI (2.97%) received a diagnosis of mood disorders in the 5-year follow-up period compared with 1153/97,445 individuals (1.52%) without antecedent TBI. After adjusting for select premorbid comorbidities, TBI remained a significant predisposing factor with a 1.96-fold (95% CI 1.74-2.22) increase in risk of mood disorders. CONCLUSIONS: Our findings show a higher likelihood of manifesting mood disorders in adolescents and young adults who sustained a prior TBI. Health professionals should carefully monitor both the physical and psychological impacts of head trauma. SN - 1097-6833 UR - https://www.unboundmedicine.com/medline/citation/24112864/Mood_disorders_after_traumatic_brain_injury_in_adolescents_and_young_adults:_a_nationwide_population_based_cohort_study_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0022-3476(13)01070-6 DB - PRIME DP - Unbound Medicine ER -