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Serum levels of vitamin E forms and risk of cognitive impairment in a Finnish cohort of older adults.

Abstract

BACKGROUND

Vitamin E includes eight natural antioxidant compounds (four tocopherols and four tocotrienols), but α-tocopherol has been the main focus of investigation in studies of cognitive impairment and Alzheimer's disease.

OBJECTIVE

To investigate the association between serum levels of tocopherols and tocotrienols, markers of vitamin E oxidative/nitrosative damage (α-tocopherylquinone, 5-nitro-γ-tocopherol) and incidence of cognitive impairment in a population-based study.

DESIGN

A sample of 140 non-cognitively impaired elderly subjects derived from the Cardiovascular Risk Factors, Aging, and Dementia (CAIDE) study was followed-up for 8years to detect cognitive impairment, defined as development of mild cognitive impairment (MCI) or Alzheimer's dementia. The association between baseline serum vitamin E and cognitive impairment was analyzed with multiple logistic regression after adjusting for several confounders.

RESULTS

The risk of cognitive impairment was lower in subjects in the middle tertile of the γ-tocopherol/cholesterol ratio than in those in the lowest tertile: the multiadjusted odds ratio (OR) with 95% confidence interval (CI) was 0.27 (0.10-0.78). Higher incidence of cognitive impairment was found in the middle [OR (95% CI): 3.41 (1.29-9.06)] and highest [OR (95% CI): 2.89 (1.05-7.97)] tertiles of the 5-NO2-γ-tocopherol/γ-tocopherol ratio. Analyses of absolute serum levels of vitamin E showed lower risk of cognitive impairment in subjects with higher levels of γ-tocopherol, β-tocotrienol, and total tocotrienols.

CONCLUSIONS

Elevated levels of tocopherol and tocotrienol forms are associated with reduced risk of cognitive impairment in older adults. The association is modulated by concurrent cholesterol concentration. Various vitamin E forms might play a role in cognitive impairment, and their evaluation can provide a more accurate measure of vitamin E status in humans.

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  • Authors+Show Affiliations

    ,

    Aging Research Center, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet and Stockholm University, Stockholm, Sweden; Institute of Gerontology and Geriatrics, Department of Clinical and Experimental Medicine, University of Perugia, Perugia, Italy. Electronic address: francesca.mangialasche@ki.se.

    , , , , , , , ,

    Source

    Experimental gerontology 48:12 2013 Dec pg 1428-35

    MeSH

    Age Factors
    Aged
    Aging
    Alzheimer Disease
    Biomarkers
    Chi-Square Distribution
    Cholesterol
    Cognition
    Cognitive Dysfunction
    Disease Progression
    Female
    Finland
    Humans
    Incidence
    Linear Models
    Logistic Models
    Male
    Odds Ratio
    Oxidative Stress
    Prospective Studies
    Risk Factors
    Time Factors
    Tocopherols
    Tocotrienols
    Vitamin E

    Pub Type(s)

    Journal Article
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    24113154

    Citation

    Mangialasche, Francesca, et al. "Serum Levels of Vitamin E Forms and Risk of Cognitive Impairment in a Finnish Cohort of Older Adults." Experimental Gerontology, vol. 48, no. 12, 2013, pp. 1428-35.
    Mangialasche F, Solomon A, Kåreholt I, et al. Serum levels of vitamin E forms and risk of cognitive impairment in a Finnish cohort of older adults. Exp Gerontol. 2013;48(12):1428-35.
    Mangialasche, F., Solomon, A., Kåreholt, I., Hooshmand, B., Cecchetti, R., Fratiglioni, L., ... Kivipelto, M. (2013). Serum levels of vitamin E forms and risk of cognitive impairment in a Finnish cohort of older adults. Experimental Gerontology, 48(12), pp. 1428-35. doi:10.1016/j.exger.2013.09.006.
    Mangialasche F, et al. Serum Levels of Vitamin E Forms and Risk of Cognitive Impairment in a Finnish Cohort of Older Adults. Exp Gerontol. 2013;48(12):1428-35. PubMed PMID: 24113154.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Serum levels of vitamin E forms and risk of cognitive impairment in a Finnish cohort of older adults. AU - Mangialasche,Francesca, AU - Solomon,Alina, AU - Kåreholt,Ingemar, AU - Hooshmand,Babak, AU - Cecchetti,Roberta, AU - Fratiglioni,Laura, AU - Soininen,Hilkka, AU - Laatikainen,Tiina, AU - Mecocci,Patrizia, AU - Kivipelto,Miia, Y1 - 2013/10/07/ PY - 2013/04/25/received PY - 2013/09/25/revised PY - 2013/09/26/accepted PY - 2013/10/12/entrez PY - 2013/10/12/pubmed PY - 2014/7/31/medline KW - 5-NO(2)-γ-tocopherol KW - 5-nitro-γ-tocopherol KW - AD KW - APOE KW - Alzheimer's disease KW - Apolipoprotein E KW - BMI KW - Body mass index KW - CAIDE KW - CDR KW - CERAD KW - CI KW - CNS KW - CV KW - Cardiovascular Risk Factors, Aging, and Dementia study KW - Central nervous system KW - Clinical Dementia Rating Scale KW - Coefficient of variation KW - Cognitive impairment KW - Confidence interval KW - Consortium to Establish a Registry for Alzheimer's Disease KW - DSM-IV KW - Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition KW - HDL KW - HPLC KW - High Performance Liquid Chromatography KW - High-density lipoprotein KW - LDL KW - Low-density lipoprotein KW - MCI KW - MMSE KW - MRI KW - Magnetic resonance imaging KW - Mini-Mental State Examination KW - NINCDS-ADRDA KW - NS KW - National Institute of Neurologic and Communicative Disorders and Stroke–Alzheimer's Disease and Related Disorders Association KW - Nitrosative stress KW - OR KW - OS KW - Odds ratio KW - Oxidative stress KW - Oxidative/nitrosative stress KW - RNS KW - Reactive nitrogen species KW - SD KW - Standard deviation KW - Tocopherol KW - Tocotrienol KW - Vitamin E KW - mild cognitive impairment KW - α-Tocopherylquinone KW - αTQ SP - 1428 EP - 35 JF - Experimental gerontology JO - Exp. Gerontol. VL - 48 IS - 12 N2 - BACKGROUND: Vitamin E includes eight natural antioxidant compounds (four tocopherols and four tocotrienols), but α-tocopherol has been the main focus of investigation in studies of cognitive impairment and Alzheimer's disease. OBJECTIVE: To investigate the association between serum levels of tocopherols and tocotrienols, markers of vitamin E oxidative/nitrosative damage (α-tocopherylquinone, 5-nitro-γ-tocopherol) and incidence of cognitive impairment in a population-based study. DESIGN: A sample of 140 non-cognitively impaired elderly subjects derived from the Cardiovascular Risk Factors, Aging, and Dementia (CAIDE) study was followed-up for 8years to detect cognitive impairment, defined as development of mild cognitive impairment (MCI) or Alzheimer's dementia. The association between baseline serum vitamin E and cognitive impairment was analyzed with multiple logistic regression after adjusting for several confounders. RESULTS: The risk of cognitive impairment was lower in subjects in the middle tertile of the γ-tocopherol/cholesterol ratio than in those in the lowest tertile: the multiadjusted odds ratio (OR) with 95% confidence interval (CI) was 0.27 (0.10-0.78). Higher incidence of cognitive impairment was found in the middle [OR (95% CI): 3.41 (1.29-9.06)] and highest [OR (95% CI): 2.89 (1.05-7.97)] tertiles of the 5-NO2-γ-tocopherol/γ-tocopherol ratio. Analyses of absolute serum levels of vitamin E showed lower risk of cognitive impairment in subjects with higher levels of γ-tocopherol, β-tocotrienol, and total tocotrienols. CONCLUSIONS: Elevated levels of tocopherol and tocotrienol forms are associated with reduced risk of cognitive impairment in older adults. The association is modulated by concurrent cholesterol concentration. Various vitamin E forms might play a role in cognitive impairment, and their evaluation can provide a more accurate measure of vitamin E status in humans. SN - 1873-6815 UR - https://www.unboundmedicine.com/medline/citation/24113154/Serum_levels_of_vitamin_E_forms_and_risk_of_cognitive_impairment_in_a_Finnish_cohort_of_older_adults_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0531-5565(13)00287-8 DB - PRIME DP - Unbound Medicine ER -