Citation
Mangialasche, Francesca, et al. "Serum Levels of Vitamin E Forms and Risk of Cognitive Impairment in a Finnish Cohort of Older Adults." Experimental Gerontology, vol. 48, no. 12, 2013, pp. 1428-35.
Mangialasche F, Solomon A, Kåreholt I, et al. Serum levels of vitamin E forms and risk of cognitive impairment in a Finnish cohort of older adults. Exp Gerontol. 2013;48(12):1428-35.
Mangialasche, F., Solomon, A., Kåreholt, I., Hooshmand, B., Cecchetti, R., Fratiglioni, L., Soininen, H., Laatikainen, T., Mecocci, P., & Kivipelto, M. (2013). Serum levels of vitamin E forms and risk of cognitive impairment in a Finnish cohort of older adults. Experimental Gerontology, 48(12), 1428-35. https://doi.org/10.1016/j.exger.2013.09.006
Mangialasche F, et al. Serum Levels of Vitamin E Forms and Risk of Cognitive Impairment in a Finnish Cohort of Older Adults. Exp Gerontol. 2013;48(12):1428-35. PubMed PMID: 24113154.
TY - JOUR
T1 - Serum levels of vitamin E forms and risk of cognitive impairment in a Finnish cohort of older adults.
AU - Mangialasche,Francesca,
AU - Solomon,Alina,
AU - Kåreholt,Ingemar,
AU - Hooshmand,Babak,
AU - Cecchetti,Roberta,
AU - Fratiglioni,Laura,
AU - Soininen,Hilkka,
AU - Laatikainen,Tiina,
AU - Mecocci,Patrizia,
AU - Kivipelto,Miia,
Y1 - 2013/10/07/
PY - 2013/04/25/received
PY - 2013/09/25/revised
PY - 2013/09/26/accepted
PY - 2013/10/12/entrez
PY - 2013/10/12/pubmed
PY - 2014/7/31/medline
KW - 5-NO(2)-γ-tocopherol
KW - 5-nitro-γ-tocopherol
KW - AD
KW - APOE
KW - Alzheimer's disease
KW - Apolipoprotein E
KW - BMI
KW - Body mass index
KW - CAIDE
KW - CDR
KW - CERAD
KW - CI
KW - CNS
KW - CV
KW - Cardiovascular Risk Factors, Aging, and Dementia study
KW - Central nervous system
KW - Clinical Dementia Rating Scale
KW - Coefficient of variation
KW - Cognitive impairment
KW - Confidence interval
KW - Consortium to Establish a Registry for Alzheimer's Disease
KW - DSM-IV
KW - Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition
KW - HDL
KW - HPLC
KW - High Performance Liquid Chromatography
KW - High-density lipoprotein
KW - LDL
KW - Low-density lipoprotein
KW - MCI
KW - MMSE
KW - MRI
KW - Magnetic resonance imaging
KW - Mini-Mental State Examination
KW - NINCDS-ADRDA
KW - NS
KW - National Institute of Neurologic and Communicative Disorders and Stroke–Alzheimer's Disease and Related Disorders Association
KW - Nitrosative stress
KW - OR
KW - OS
KW - Odds ratio
KW - Oxidative stress
KW - Oxidative/nitrosative stress
KW - RNS
KW - Reactive nitrogen species
KW - SD
KW - Standard deviation
KW - Tocopherol
KW - Tocotrienol
KW - Vitamin E
KW - mild cognitive impairment
KW - α-Tocopherylquinone
KW - αTQ
SP - 1428
EP - 35
JF - Experimental gerontology
JO - Exp Gerontol
VL - 48
IS - 12
N2 - BACKGROUND: Vitamin E includes eight natural antioxidant compounds (four tocopherols and four tocotrienols), but α-tocopherol has been the main focus of investigation in studies of cognitive impairment and Alzheimer's disease. OBJECTIVE: To investigate the association between serum levels of tocopherols and tocotrienols, markers of vitamin E oxidative/nitrosative damage (α-tocopherylquinone, 5-nitro-γ-tocopherol) and incidence of cognitive impairment in a population-based study. DESIGN: A sample of 140 non-cognitively impaired elderly subjects derived from the Cardiovascular Risk Factors, Aging, and Dementia (CAIDE) study was followed-up for 8years to detect cognitive impairment, defined as development of mild cognitive impairment (MCI) or Alzheimer's dementia. The association between baseline serum vitamin E and cognitive impairment was analyzed with multiple logistic regression after adjusting for several confounders. RESULTS: The risk of cognitive impairment was lower in subjects in the middle tertile of the γ-tocopherol/cholesterol ratio than in those in the lowest tertile: the multiadjusted odds ratio (OR) with 95% confidence interval (CI) was 0.27 (0.10-0.78). Higher incidence of cognitive impairment was found in the middle [OR (95% CI): 3.41 (1.29-9.06)] and highest [OR (95% CI): 2.89 (1.05-7.97)] tertiles of the 5-NO2-γ-tocopherol/γ-tocopherol ratio. Analyses of absolute serum levels of vitamin E showed lower risk of cognitive impairment in subjects with higher levels of γ-tocopherol, β-tocotrienol, and total tocotrienols. CONCLUSIONS: Elevated levels of tocopherol and tocotrienol forms are associated with reduced risk of cognitive impairment in older adults. The association is modulated by concurrent cholesterol concentration. Various vitamin E forms might play a role in cognitive impairment, and their evaluation can provide a more accurate measure of vitamin E status in humans.
SN - 1873-6815
UR - https://www.unboundmedicine.com/medline/citation/24113154/Serum_levels_of_vitamin_E_forms_and_risk_of_cognitive_impairment_in_a_Finnish_cohort_of_older_adults_
L2 - https://linkinghub.elsevier.com/retrieve/pii/S0531-5565(13)00287-8
DB - PRIME
DP - Unbound Medicine
ER -