TY - JOUR T1 - Serum levels of vitamin E forms and risk of cognitive impairment in a Finnish cohort of older adults. AU - Mangialasche,Francesca, AU - Solomon,Alina, AU - Kåreholt,Ingemar, AU - Hooshmand,Babak, AU - Cecchetti,Roberta, AU - Fratiglioni,Laura, AU - Soininen,Hilkka, AU - Laatikainen,Tiina, AU - Mecocci,Patrizia, AU - Kivipelto,Miia, Y1 - 2013/10/07/ PY - 2013/04/25/received PY - 2013/09/25/revised PY - 2013/09/26/accepted PY - 2013/10/12/entrez PY - 2013/10/12/pubmed PY - 2014/7/31/medline KW - 5-NO(2)-γ-tocopherol KW - 5-nitro-γ-tocopherol KW - AD KW - APOE KW - Alzheimer's disease KW - Apolipoprotein E KW - BMI KW - Body mass index KW - CAIDE KW - CDR KW - CERAD KW - CI KW - CNS KW - CV KW - Cardiovascular Risk Factors, Aging, and Dementia study KW - Central nervous system KW - Clinical Dementia Rating Scale KW - Coefficient of variation KW - Cognitive impairment KW - Confidence interval KW - Consortium to Establish a Registry for Alzheimer's Disease KW - DSM-IV KW - Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition KW - HDL KW - HPLC KW - High Performance Liquid Chromatography KW - High-density lipoprotein KW - LDL KW - Low-density lipoprotein KW - MCI KW - MMSE KW - MRI KW - Magnetic resonance imaging KW - Mini-Mental State Examination KW - NINCDS-ADRDA KW - NS KW - National Institute of Neurologic and Communicative Disorders and Stroke–Alzheimer's Disease and Related Disorders Association KW - Nitrosative stress KW - OR KW - OS KW - Odds ratio KW - Oxidative stress KW - Oxidative/nitrosative stress KW - RNS KW - Reactive nitrogen species KW - SD KW - Standard deviation KW - Tocopherol KW - Tocotrienol KW - Vitamin E KW - mild cognitive impairment KW - α-Tocopherylquinone KW - αTQ SP - 1428 EP - 35 JF - Experimental gerontology JO - Exp Gerontol VL - 48 IS - 12 N2 - BACKGROUND: Vitamin E includes eight natural antioxidant compounds (four tocopherols and four tocotrienols), but α-tocopherol has been the main focus of investigation in studies of cognitive impairment and Alzheimer's disease. OBJECTIVE: To investigate the association between serum levels of tocopherols and tocotrienols, markers of vitamin E oxidative/nitrosative damage (α-tocopherylquinone, 5-nitro-γ-tocopherol) and incidence of cognitive impairment in a population-based study. DESIGN: A sample of 140 non-cognitively impaired elderly subjects derived from the Cardiovascular Risk Factors, Aging, and Dementia (CAIDE) study was followed-up for 8years to detect cognitive impairment, defined as development of mild cognitive impairment (MCI) or Alzheimer's dementia. The association between baseline serum vitamin E and cognitive impairment was analyzed with multiple logistic regression after adjusting for several confounders. RESULTS: The risk of cognitive impairment was lower in subjects in the middle tertile of the γ-tocopherol/cholesterol ratio than in those in the lowest tertile: the multiadjusted odds ratio (OR) with 95% confidence interval (CI) was 0.27 (0.10-0.78). Higher incidence of cognitive impairment was found in the middle [OR (95% CI): 3.41 (1.29-9.06)] and highest [OR (95% CI): 2.89 (1.05-7.97)] tertiles of the 5-NO2-γ-tocopherol/γ-tocopherol ratio. Analyses of absolute serum levels of vitamin E showed lower risk of cognitive impairment in subjects with higher levels of γ-tocopherol, β-tocotrienol, and total tocotrienols. CONCLUSIONS: Elevated levels of tocopherol and tocotrienol forms are associated with reduced risk of cognitive impairment in older adults. The association is modulated by concurrent cholesterol concentration. Various vitamin E forms might play a role in cognitive impairment, and their evaluation can provide a more accurate measure of vitamin E status in humans. SN - 1873-6815 UR - https://www.unboundmedicine.com/medline/citation/24113154/Serum_levels_of_vitamin_E_forms_and_risk_of_cognitive_impairment_in_a_Finnish_cohort_of_older_adults_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0531-5565(13)00287-8 DB - PRIME DP - Unbound Medicine ER -