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Copper-catalyzed trifluoromethylation-cyclization of enynes: highly regioselective construction of trifluoromethylated carbocycles and heterocycles.
Chemistry. 2013 Oct 18; 19(43):14420-4.C

Abstract

Regioselective trifluoromethylation-cyclization: A method for copper-catalyzed trifluoromethylation-cyclization of simple enynes using the CC triple bond as a nucleophile is reported for the first time. The reaction proceeds efficiently in a highly regioselective manner to give various 5- or 6-exo-dig carbocycles and heterocycles in moderate to high yields.

Links

Publisher Full Text (DOI)

Authors+Show Affiliations

Gao P
State key Laboratory of Applied Organic Chemistry lanzhou University, Lanzhou 730000 (P. R. China), Fax: (+86) 931-891-2582.
Yan XB
No affiliation info available
Tao T
No affiliation info available
Yang F
No affiliation info available
He T
No affiliation info available
Song XR
No affiliation info available
Liu XY
No affiliation info available
Liang YM
No affiliation info available

MeSH

AlkynesCarbonCatalysisCopperCyclizationFluorineHeterocyclic CompoundsMethylationStereoisomerism

Pub Type(s)

Journal Article
Research Support, U.S. Gov't, Non-P.H.S.

Language

eng

PubMed ID

24114879

Citation

Gao, Pin, et al. "Copper-catalyzed Trifluoromethylation-cyclization of Enynes: Highly Regioselective Construction of Trifluoromethylated Carbocycles and Heterocycles." Chemistry (Weinheim an Der Bergstrasse, Germany), vol. 19, no. 43, 2013, pp. 14420-4.
Gao P, Yan XB, Tao T, et al. Copper-catalyzed trifluoromethylation-cyclization of enynes: highly regioselective construction of trifluoromethylated carbocycles and heterocycles. Chemistry. 2013;19(43):14420-4.
Gao, P., Yan, X. B., Tao, T., Yang, F., He, T., Song, X. R., Liu, X. Y., & Liang, Y. M. (2013). Copper-catalyzed trifluoromethylation-cyclization of enynes: highly regioselective construction of trifluoromethylated carbocycles and heterocycles. Chemistry (Weinheim an Der Bergstrasse, Germany), 19(43), 14420-4. https://doi.org/10.1002/chem.201303025
Gao P, et al. Copper-catalyzed Trifluoromethylation-cyclization of Enynes: Highly Regioselective Construction of Trifluoromethylated Carbocycles and Heterocycles. Chemistry. 2013 Oct 18;19(43):14420-4. PubMed PMID: 24114879.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Copper-catalyzed trifluoromethylation-cyclization of enynes: highly regioselective construction of trifluoromethylated carbocycles and heterocycles. AU - Gao,Pin, AU - Yan,Xiao-Biao, AU - Tao,Tao, AU - Yang,Fan, AU - He,Ting, AU - Song,Xian-Rong, AU - Liu,Xue-Yuan, AU - Liang,Yong-Min, Y1 - 2013/09/23/ PY - 2013/07/31/received PY - 2013/10/12/entrez PY - 2013/10/12/pubmed PY - 2014/5/16/medline KW - copper KW - cyclization KW - enynes KW - regioselectivity KW - trifluoromethylation SP - 14420 EP - 4 JF - Chemistry (Weinheim an der Bergstrasse, Germany) JO - Chemistry VL - 19 IS - 43 N2 - Regioselective trifluoromethylation-cyclization: A method for copper-catalyzed trifluoromethylation-cyclization of simple enynes using the CC triple bond as a nucleophile is reported for the first time. The reaction proceeds efficiently in a highly regioselective manner to give various 5- or 6-exo-dig carbocycles and heterocycles in moderate to high yields. SN - 1521-3765 UR - https://www.unboundmedicine.com/medline/citation/24114879/Copper_catalyzed_trifluoromethylation_cyclization_of_enynes:_highly_regioselective_construction_of_trifluoromethylated_carbocycles_and_heterocycles_ L2 - https://doi.org/10.1002/chem.201303025 DB - PRIME DP - Unbound Medicine ER -