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Acceleration of dermal wound healing by using electrospun curcumin-loaded poly(ε-caprolactone)-poly(ethylene glycol)-poly(ε-caprolactone) fibrous mats.

Abstract

This study prepared a composite scaffold composed of curcumin and poly(ε-caprolactone)-poly(ethylene glycol)-poly(ε-caprolactone) (PCL-PEG-PCL, PCEC) copolymer using coelectrospinning technology. Incorporation of curcumin into the polymeric matrix had an obvious effect on the morphology and dimension of PCEC/curcumin fibers. The results of in vitro anti-oxidant tests and of the cytotoxicity assay demonstrated that the curcumin-loaded PCEC fibrous mats had significant anti-oxidant efficacy and low cytotoxicity. Curcumin could be sustainably released from the fibrous scaffolds. More importantly, in vivo efficacy in enhancing wound repair was also investigated based on a full-thickness dermal defect model for Wistar rats. The results indicated that the PCEC/curcumin fibrous mats had a significant advantage in promoting wound healing. At 21 days post-operation, the dermal defect was basically recovered to its normal condition. A percentage of wound closure reached up to 93.3 ± 5.6% compared with 76.9 ± 4.9% of the untreated control (p < 0.05). Therefore, the as-prepared PCEC/curcumin composite mats are a promising candidate for use as wound dressing.

Authors+Show Affiliations

Department of Oncology, the Affiliated Hospital of Luzhou Medical College, Luzhou, 646000, China.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

24115465

Citation

Fu, Shao-Zhi, et al. "Acceleration of Dermal Wound Healing By Using Electrospun Curcumin-loaded Poly(ε-caprolactone)-poly(ethylene Glycol)-poly(ε-caprolactone) Fibrous Mats." Journal of Biomedical Materials Research. Part B, Applied Biomaterials, vol. 102, no. 3, 2014, pp. 533-42.
Fu SZ, Meng XH, Fan J, et al. Acceleration of dermal wound healing by using electrospun curcumin-loaded poly(ε-caprolactone)-poly(ethylene glycol)-poly(ε-caprolactone) fibrous mats. J Biomed Mater Res Part B Appl Biomater. 2014;102(3):533-42.
Fu, S. Z., Meng, X. H., Fan, J., Yang, L. L., Wen, Q. L., Ye, S. J., ... Li, Z. (2014). Acceleration of dermal wound healing by using electrospun curcumin-loaded poly(ε-caprolactone)-poly(ethylene glycol)-poly(ε-caprolactone) fibrous mats. Journal of Biomedical Materials Research. Part B, Applied Biomaterials, 102(3), pp. 533-42. doi:10.1002/jbm.b.33032.
Fu SZ, et al. Acceleration of Dermal Wound Healing By Using Electrospun Curcumin-loaded Poly(ε-caprolactone)-poly(ethylene Glycol)-poly(ε-caprolactone) Fibrous Mats. J Biomed Mater Res Part B Appl Biomater. 2014;102(3):533-42. PubMed PMID: 24115465.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Acceleration of dermal wound healing by using electrospun curcumin-loaded poly(ε-caprolactone)-poly(ethylene glycol)-poly(ε-caprolactone) fibrous mats. AU - Fu,Shao-Zhi, AU - Meng,Xiao-Hang, AU - Fan,Juan, AU - Yang,Ling-Lin, AU - Wen,Qing-Lian, AU - Ye,Su-Juan, AU - Lin,Sheng, AU - Wang,Bi-Qiong, AU - Chen,Lan-Lan, AU - Wu,Jing-Bo, AU - Chen,Yue, AU - Fan,Jun-Ming, AU - Li,Zhi, Y1 - 2013/09/20/ PY - 2013/04/15/received PY - 2013/08/12/revised PY - 2013/08/18/accepted PY - 2013/10/12/entrez PY - 2013/10/12/pubmed PY - 2014/11/13/medline KW - PCL-PEG-PCL KW - curcumin KW - dermal defect KW - fibrous mats KW - wound healing SP - 533 EP - 42 JF - Journal of biomedical materials research. Part B, Applied biomaterials JO - J. Biomed. Mater. Res. Part B Appl. Biomater. VL - 102 IS - 3 N2 - This study prepared a composite scaffold composed of curcumin and poly(ε-caprolactone)-poly(ethylene glycol)-poly(ε-caprolactone) (PCL-PEG-PCL, PCEC) copolymer using coelectrospinning technology. Incorporation of curcumin into the polymeric matrix had an obvious effect on the morphology and dimension of PCEC/curcumin fibers. The results of in vitro anti-oxidant tests and of the cytotoxicity assay demonstrated that the curcumin-loaded PCEC fibrous mats had significant anti-oxidant efficacy and low cytotoxicity. Curcumin could be sustainably released from the fibrous scaffolds. More importantly, in vivo efficacy in enhancing wound repair was also investigated based on a full-thickness dermal defect model for Wistar rats. The results indicated that the PCEC/curcumin fibrous mats had a significant advantage in promoting wound healing. At 21 days post-operation, the dermal defect was basically recovered to its normal condition. A percentage of wound closure reached up to 93.3 ± 5.6% compared with 76.9 ± 4.9% of the untreated control (p < 0.05). Therefore, the as-prepared PCEC/curcumin composite mats are a promising candidate for use as wound dressing. SN - 1552-4981 UR - https://www.unboundmedicine.com/medline/citation/24115465/Acceleration_of_dermal_wound_healing_by_using_electrospun_curcumin_loaded_poly_ε_caprolactone__poly_ethylene_glycol__poly_ε_caprolactone__fibrous_mats_ L2 - https://doi.org/10.1002/jbm.b.33032 DB - PRIME DP - Unbound Medicine ER -