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Protection against hepatitis E virus infection by naturally acquired and vaccine-induced immunity.
Clin Microbiol Infect 2014; 20(6):O397-405CM

Abstract

Immunity acquired from infection or vaccination protects humans from symptomatic hepatitis E. However, whether the risk of hepatitis E virus (HEV) infection is reduced by the immunity remains unknown. To understand this issue, a cohort with 12 409 participants randomized to receive the hepatitis E vaccine Hecolin(®) or placebo were serologically followed up for 2 years after vaccination. About half (47%) of participants were initially seropositive. A total of 139 infection episodes, evidenced by four-fold or greater rise of anti-HEV level or positive seroconversion, occurred in participants who received three doses of treatment. Risk of infection was highest among the baseline seronegative placebo group participants (2.04%). Pre-existing immunity and vaccine-induced immunity lower the risk significantly, to 0.52% and 0.30%, respectively. In conclusion, both vaccine-induced and naturally acquired immunity can effectively protect against HEV infection.

Authors+Show Affiliations

National Institute of Diagnostics and Vaccine Development in Infectious Diseases, School of Public Health, Xiamen University, Xiamen, China.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

24118636

Citation

Zhang, J, et al. "Protection Against Hepatitis E Virus Infection By Naturally Acquired and Vaccine-induced Immunity." Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases, vol. 20, no. 6, 2014, pp. O397-405.
Zhang J, Zhang XF, Zhou C, et al. Protection against hepatitis E virus infection by naturally acquired and vaccine-induced immunity. Clin Microbiol Infect. 2014;20(6):O397-405.
Zhang, J., Zhang, X. F., Zhou, C., Wang, Z. Z., Huang, S. J., Yao, X., ... Xia, N. S. (2014). Protection against hepatitis E virus infection by naturally acquired and vaccine-induced immunity. Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases, 20(6), pp. O397-405. doi:10.1111/1469-0691.12419.
Zhang J, et al. Protection Against Hepatitis E Virus Infection By Naturally Acquired and Vaccine-induced Immunity. Clin Microbiol Infect. 2014;20(6):O397-405. PubMed PMID: 24118636.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Protection against hepatitis E virus infection by naturally acquired and vaccine-induced immunity. AU - Zhang,J, AU - Zhang,X-F, AU - Zhou,C, AU - Wang,Z-Z, AU - Huang,S-J, AU - Yao,X, AU - Liang,Z-L, AU - Wu,T, AU - Li,J-X, AU - Yan,Q, AU - Yang,C-L, AU - Jiang,H-M, AU - Huang,H-J, AU - Xian,Y-L, AU - Shih,J W-K, AU - Ng,M-H, AU - Li,Y-M, AU - Wang,J-Z, AU - Zhu,F-C, AU - Xia,N-S, Y1 - 2013/11/18/ PY - 2013/07/03/received PY - 2013/09/08/revised PY - 2013/09/29/accepted PY - 2013/10/15/entrez PY - 2013/10/15/pubmed PY - 2015/3/31/medline KW - Antibody level KW - hepatitis E virus KW - immunity KW - infection KW - vaccine SP - O397 EP - 405 JF - Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases JO - Clin. Microbiol. Infect. VL - 20 IS - 6 N2 - Immunity acquired from infection or vaccination protects humans from symptomatic hepatitis E. However, whether the risk of hepatitis E virus (HEV) infection is reduced by the immunity remains unknown. To understand this issue, a cohort with 12 409 participants randomized to receive the hepatitis E vaccine Hecolin(®) or placebo were serologically followed up for 2 years after vaccination. About half (47%) of participants were initially seropositive. A total of 139 infection episodes, evidenced by four-fold or greater rise of anti-HEV level or positive seroconversion, occurred in participants who received three doses of treatment. Risk of infection was highest among the baseline seronegative placebo group participants (2.04%). Pre-existing immunity and vaccine-induced immunity lower the risk significantly, to 0.52% and 0.30%, respectively. In conclusion, both vaccine-induced and naturally acquired immunity can effectively protect against HEV infection. SN - 1469-0691 UR - https://www.unboundmedicine.com/medline/citation/24118636/Protection_against_hepatitis_E_virus_infection_by_naturally_acquired_and_vaccine_induced_immunity_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1198-743X(14)64170-7 DB - PRIME DP - Unbound Medicine ER -