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Double-blind, randomized, controlled clinical trial of the effects of diosmectite and basic fibroblast growth factor paste on the treatment of minor recurrent aphthous stomatitis.

Abstract

OBJECTIVE

This study investigated the effectiveness and safety of topical application of diosmectite (DS) and basic fibroblast growth factor (bFGF) paste in the treatment of minor recurrent aphthous stomatitis.

STUDY DESIGN

Four pastes, containing bFGF and DS, DS alone, bFGF alone, and vehicle only, were consecutively applied 4 times per day for 5 days. Pain levels and the amount of ulcer amelioration were evaluated.

RESULTS

A total of 129 participants completed the study. DS+bFGF paste released bFGF continuously and significantly lowered ulcer pain scores (P < .05 for days 3, 4, 5, and 6) compared with the other pastes. The ulcer size was significantly reduced (P < .05 for days 2, 4, and 6) in the DS+bFGF paste group compared with the other groups. No obvious adverse drug effects were observed.

CONCLUSIONS

DS+bFGF paste was effective in alleviating ulcer pain and promoting healing without significant side effects in the treatment of minor recurrent aphthous stomatitis.

Authors+Show Affiliations

Department of Stomatology, First People's Hospital of Chenzhou and University of South China, Chenzhou, Hunan, China; Institute of Translation Medicine, University of South China, Chenzhou, Hunan, China. Electronic address: jxw0927@yahoo.com.cn.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

24119521

Citation

Jiang, Xiao-Wen, et al. "Double-blind, Randomized, Controlled Clinical Trial of the Effects of Diosmectite and Basic Fibroblast Growth Factor Paste On the Treatment of Minor Recurrent Aphthous Stomatitis." Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology, vol. 116, no. 5, 2013, pp. 570-5.
Jiang XW, Zhang Y, Zhang H, et al. Double-blind, randomized, controlled clinical trial of the effects of diosmectite and basic fibroblast growth factor paste on the treatment of minor recurrent aphthous stomatitis. Oral Surg Oral Med Oral Pathol Oral Radiol. 2013;116(5):570-5.
Jiang, X. W., Zhang, Y., Zhang, H., Lu, K., Yang, S. K., & Sun, G. L. (2013). Double-blind, randomized, controlled clinical trial of the effects of diosmectite and basic fibroblast growth factor paste on the treatment of minor recurrent aphthous stomatitis. Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology, 116(5), 570-5. https://doi.org/10.1016/j.oooo.2013.07.003
Jiang XW, et al. Double-blind, Randomized, Controlled Clinical Trial of the Effects of Diosmectite and Basic Fibroblast Growth Factor Paste On the Treatment of Minor Recurrent Aphthous Stomatitis. Oral Surg Oral Med Oral Pathol Oral Radiol. 2013;116(5):570-5. PubMed PMID: 24119521.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Double-blind, randomized, controlled clinical trial of the effects of diosmectite and basic fibroblast growth factor paste on the treatment of minor recurrent aphthous stomatitis. AU - Jiang,Xiao-Wen, AU - Zhang,Yi, AU - Zhang,Hao, AU - Lu,Kun, AU - Yang,Shou-Kang, AU - Sun,Guo-Liang, PY - 2013/03/13/received PY - 2013/07/03/revised PY - 2013/07/07/accepted PY - 2013/10/15/entrez PY - 2013/10/15/pubmed PY - 2014/7/2/medline SP - 570 EP - 5 JF - Oral surgery, oral medicine, oral pathology and oral radiology JO - Oral Surg Oral Med Oral Pathol Oral Radiol VL - 116 IS - 5 N2 - OBJECTIVE: This study investigated the effectiveness and safety of topical application of diosmectite (DS) and basic fibroblast growth factor (bFGF) paste in the treatment of minor recurrent aphthous stomatitis. STUDY DESIGN: Four pastes, containing bFGF and DS, DS alone, bFGF alone, and vehicle only, were consecutively applied 4 times per day for 5 days. Pain levels and the amount of ulcer amelioration were evaluated. RESULTS: A total of 129 participants completed the study. DS+bFGF paste released bFGF continuously and significantly lowered ulcer pain scores (P < .05 for days 3, 4, 5, and 6) compared with the other pastes. The ulcer size was significantly reduced (P < .05 for days 2, 4, and 6) in the DS+bFGF paste group compared with the other groups. No obvious adverse drug effects were observed. CONCLUSIONS: DS+bFGF paste was effective in alleviating ulcer pain and promoting healing without significant side effects in the treatment of minor recurrent aphthous stomatitis. SN - 2212-4411 UR - https://www.unboundmedicine.com/medline/citation/24119521/Double_blind_randomized_controlled_clinical_trial_of_the_effects_of_diosmectite_and_basic_fibroblast_growth_factor_paste_on_the_treatment_of_minor_recurrent_aphthous_stomatitis_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S2212-4403(13)00386-6 DB - PRIME DP - Unbound Medicine ER -