TY - JOUR T1 - Protective effect of cytomegalovirus reactivation on relapse after allogeneic hematopoietic cell transplantation in acute myeloid leukemia patients is influenced by conditioning regimen. AU - Manjappa,Shivaprasad, AU - Bhamidipati,Pavan Kumar, AU - Stokerl-Goldstein,Keith E, AU - DiPersio,John F, AU - Uy,Geoffrey L, AU - Westervelt,Peter, AU - Liu,Jingxia, AU - Schroeder,Mark A, AU - Vij,Ravi, AU - Abboud,Camille N, AU - Fehniger,Todd A, AU - Cashen,Amanda F, AU - Pusic,Iskra, AU - Jacoby,Meagan, AU - Meera,Srinidhi J, AU - Romee,Rizwan, Y1 - 2013/10/10/ PY - 2013/08/27/received PY - 2013/10/02/accepted PY - 2013/10/15/entrez PY - 2013/10/15/pubmed PY - 2014/8/13/medline KW - Acute myeloid leukemia KW - Allogeneic hematopoietic cell transplantation KW - CMV KW - Myeloablative KW - Reduced intensity KW - Relapse SP - 46 EP - 52 JF - Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation JO - Biol Blood Marrow Transplant VL - 20 IS - 1 N2 - Cytomegalovirus (CMV) reactivation after allogeneic hematopoietic cell transplant (allo-HCT) has been associated with a reduced risk of relapse in patients with acute myeloid leukemia (AML). However, the influence of the conditioning regimen on this protective effect of CMV reactivation after allo-HCT is relatively unexplored. To address this, we evaluated the risk of relapse in 264 AML patients who received T cell-replete, 6/6 HLA matched sibling or 10/10 HLA matched unrelated donor transplantation at a single institution between 2006 and 2011. Of these 264 patients, 206 received myeloablative (MA) and 58 received reduced-intensity conditioning (RIC) regimens. CMV reactivation was observed in 88 patients with MA conditioning and 37 patients with RIC. At a median follow-up of 299 days, CMV reactivation was associated with significantly lower risk of relapse in patients who received MA conditioning both in univariate (P = .01) and multivariate analyses (hazard ratio, .5246; P = .006); however, CMV reactivation did not significantly affect the risk of relapse in our RIC cohort. These results confirm the protective effect of CMV reactivation on relapse in AML patients after allo-HCT reported by previous studies but suggest this protective effect of CMV reactivation on relapse is influenced by the conditioning regimen used with the transplant. SN - 1523-6536 UR - https://www.unboundmedicine.com/medline/citation/24120526/Protective_effect_of_cytomegalovirus_reactivation_on_relapse_after_allogeneic_hematopoietic_cell_transplantation_in_acute_myeloid_leukemia_patients_is_influenced_by_conditioning_regimen_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1083-8791(13)00449-7 DB - PRIME DP - Unbound Medicine ER -