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Pronociception from the dorsomedial nucleus of the hypothalamus is mediated by the rostral ventromedial medulla in healthy controls but is absent in arthritic animals.
Brain Res Bull. 2013 Oct; 99:100-8.BR

Abstract

The dorsomedial nucleus of the hypothalamus (DMH) has been proposed to participate in stress-induced hyperalgesia through facilitation of pronociceptive cells in the rostroventromedial medulla (RVM). We hypothesized that the DMH participates in hyperalgesia induced by arthritis. The DMH was pharmacologically manipulated while assessing heat-evoked nociceptive behavior or the discharge rates of pronociceptive RVM ON- and antinociceptive RVM OFF-like cells in NAIVE, SHAM and monoarthritic (ARTH) animals. In NAIVE and SHAM animals, the changes in nociceptive behavior induced by activation of the DMH by glutamate and inhibition by lidocaine were in line with earlier evidence indicating that the DMH has a nociceptive facilitating role. However, in ARTH animals, neither activation nor inhibition of the DMH influenced pain-like behavior evoked by stimulation of an uninflamed skin region (paw and tail). In accordance with these behavioral results, activation or inhibition of the DMH induced pronociceptive changes in the discharge rates of RVM cells in NAIVE and SHAM animals, which suggests that the DMH has a pronociceptive role mediated by the RVM in normal animals. However, in ARTH animals, both glutamate and lidocaine in the DMH failed to influence either pain-like behavior or noxious stimulation-evoked responses of RVM cells, while blocking the DMH increased spontaneous activity in the pronociceptive RVM ON cells. Our data indicate that the DMH participates in descending facilitation of cutaneous nociception in healthy controls, but it is not engaged in the regulation of cutaneous nociception in monoarthritic animals, while a minor role in tonic suppression of nociception in arthritis cannot be discarded.

Authors+Show Affiliations

Life and Health Sciences Research Institute (ICVS), School of Health Sciences (ECS), Campus of Gualtar, University of Minho, 4750-057 Braga, Portugal; ICVS/3B's - PT Government Associate Laboratory, Braga/Guimarães, Portugal.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

24121166

Citation

Pinto-Ribeiro, Filipa, et al. "Pronociception From the Dorsomedial Nucleus of the Hypothalamus Is Mediated By the Rostral Ventromedial Medulla in Healthy Controls but Is Absent in Arthritic Animals." Brain Research Bulletin, vol. 99, 2013, pp. 100-8.
Pinto-Ribeiro F, Amorim D, David-Pereira A, et al. Pronociception from the dorsomedial nucleus of the hypothalamus is mediated by the rostral ventromedial medulla in healthy controls but is absent in arthritic animals. Brain Res Bull. 2013;99:100-8.
Pinto-Ribeiro, F., Amorim, D., David-Pereira, A., Monteiro, A. M., Costa, P., Pertovaara, A., & Almeida, A. (2013). Pronociception from the dorsomedial nucleus of the hypothalamus is mediated by the rostral ventromedial medulla in healthy controls but is absent in arthritic animals. Brain Research Bulletin, 99, 100-8. https://doi.org/10.1016/j.brainresbull.2013.10.001
Pinto-Ribeiro F, et al. Pronociception From the Dorsomedial Nucleus of the Hypothalamus Is Mediated By the Rostral Ventromedial Medulla in Healthy Controls but Is Absent in Arthritic Animals. Brain Res Bull. 2013;99:100-8. PubMed PMID: 24121166.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Pronociception from the dorsomedial nucleus of the hypothalamus is mediated by the rostral ventromedial medulla in healthy controls but is absent in arthritic animals. AU - Pinto-Ribeiro,Filipa, AU - Amorim,Diana, AU - David-Pereira,Ana, AU - Monteiro,Ana Maria, AU - Costa,Patricio, AU - Pertovaara,Antti, AU - Almeida,Armando, Y1 - 2013/10/09/ PY - 2013/04/16/received PY - 2013/09/27/revised PY - 2013/10/01/accepted PY - 2013/10/15/entrez PY - 2013/10/15/pubmed PY - 2014/7/16/medline KW - ARTH KW - Arthritic pain KW - CTRL KW - DMH KW - Descending pain modulation KW - Dorsomedial hypothalamic nucleus (DMH) KW - GLU KW - H KW - HPA KW - LIDO KW - MS KW - NPS KW - ON-like cells KW - P KW - PAG KW - PW KW - Pronociception KW - RVM KW - Rostral ventromedial medulla (RVM) KW - SAL KW - TF KW - TS KW - arthritic animals/arthritis KW - control animals/controls KW - dorsomedial nucleus of the hypothalamus KW - glutamate KW - hypothalamus–pituitary–adrenal axis KW - lidocaine KW - mechanical stimulation KW - noxious peripheral stimulation KW - paw-withdrawal KW - periaqueductal gray matter KW - peripheral noxious heat stimulation KW - peripheral noxious mechanical stimulation KW - rostral ventromedial medulla KW - saline solution KW - tail-flick KW - thermal stimulation SP - 100 EP - 8 JF - Brain research bulletin JO - Brain Res Bull VL - 99 N2 - The dorsomedial nucleus of the hypothalamus (DMH) has been proposed to participate in stress-induced hyperalgesia through facilitation of pronociceptive cells in the rostroventromedial medulla (RVM). We hypothesized that the DMH participates in hyperalgesia induced by arthritis. The DMH was pharmacologically manipulated while assessing heat-evoked nociceptive behavior or the discharge rates of pronociceptive RVM ON- and antinociceptive RVM OFF-like cells in NAIVE, SHAM and monoarthritic (ARTH) animals. In NAIVE and SHAM animals, the changes in nociceptive behavior induced by activation of the DMH by glutamate and inhibition by lidocaine were in line with earlier evidence indicating that the DMH has a nociceptive facilitating role. However, in ARTH animals, neither activation nor inhibition of the DMH influenced pain-like behavior evoked by stimulation of an uninflamed skin region (paw and tail). In accordance with these behavioral results, activation or inhibition of the DMH induced pronociceptive changes in the discharge rates of RVM cells in NAIVE and SHAM animals, which suggests that the DMH has a pronociceptive role mediated by the RVM in normal animals. However, in ARTH animals, both glutamate and lidocaine in the DMH failed to influence either pain-like behavior or noxious stimulation-evoked responses of RVM cells, while blocking the DMH increased spontaneous activity in the pronociceptive RVM ON cells. Our data indicate that the DMH participates in descending facilitation of cutaneous nociception in healthy controls, but it is not engaged in the regulation of cutaneous nociception in monoarthritic animals, while a minor role in tonic suppression of nociception in arthritis cannot be discarded. SN - 1873-2747 UR - https://www.unboundmedicine.com/medline/citation/24121166/Pronociception_from_the_dorsomedial_nucleus_of_the_hypothalamus_is_mediated_by_the_rostral_ventromedial_medulla_in_healthy_controls_but_is_absent_in_arthritic_animals_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0361-9230(13)00151-2 DB - PRIME DP - Unbound Medicine ER -