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[Cellular and intracellular transport of vitamin C. The physiologic aspects].
Orv Hetil. 2013 Oct 20; 154(42):1651-6.OH

Abstract

Vitamin C requirement is satisfied by natural sources and vitamin C supplements in the ordinary human diet. The two major forms of vitamin C in the diet are L-ascorbic acid and L-dehydroascorbic acid. Both ascorbate and dehydroascorbate are absorbed along the entire length of the human intestine. The reduced form, L-ascorbic acid is imported by an active mechanism, requiring two sodium-dependent vitamin C transporters (SVCT1 and SVCT2). The transport of the oxidized form, dehydroascorbate is mediated by glucose transporters GLUT1, GLUT3 and possibly GLUT4. Initial rate of uptake of both ascorbate and dehydroascorbate is saturable with increasing external substrate concentration. Vitamin C plasma concentrations are tightly controlled when the vitamin is taken orally. It has two simple reasons, on the one hand, the capacity of the transporters is limited, on the other hand the two Na+-dependent transporters can be down-regulated by an elevated level of ascorbate.

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Authors+Show Affiliations

Szarka A
Semmelweis Egyetem, Általános Orvostudományi Kar Orvosi Vegytani Molekuláris Biológiai és Patobiokémiai Intézet Budapest Tűzoltó u. 34-47. 1097 Budapesti Műszaki és Gazdaságtudományi Egyetem Alkalmazott Biotechnológia és Élelmiszer-tudományi Tanszék, Biokémiai és Molekuláris Biológiai Laboratórium Budapest.
Lőrincz T
No affiliation info available

MeSH

AntioxidantsAscorbic AcidBiological TransportCell MembraneDehydroascorbic AcidEndoplasmic ReticulumGlucose Transporter Type 1Glucose Transporter Type 3Glucose Transporter Type 4HumansIntestinal AbsorptionMitochondriaSodium-Coupled Vitamin C TransportersVitamins

Pub Type(s)

English Abstract
Journal Article
Review

Language

hun

PubMed ID

24121217

Citation

Szarka, András, and Tamás Lőrincz. "[Cellular and Intracellular Transport of Vitamin C. the Physiologic Aspects]." Orvosi Hetilap, vol. 154, no. 42, 2013, pp. 1651-6.
Szarka A, Lőrincz T. [Cellular and intracellular transport of vitamin C. The physiologic aspects]. Orv Hetil. 2013;154(42):1651-6.
Szarka, A., & Lőrincz, T. (2013). [Cellular and intracellular transport of vitamin C. The physiologic aspects]. Orvosi Hetilap, 154(42), 1651-6. https://doi.org/10.1556/OH.2013.29712
Szarka A, Lőrincz T. [Cellular and Intracellular Transport of Vitamin C. the Physiologic Aspects]. Orv Hetil. 2013 Oct 20;154(42):1651-6. PubMed PMID: 24121217.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Cellular and intracellular transport of vitamin C. The physiologic aspects]. AU - Szarka,András, AU - Lőrincz,Tamás, PY - 2013/10/15/entrez PY - 2013/10/15/pubmed PY - 2014/3/29/medline KW - C-vitamin KW - napi ajánlott bevitel KW - recommended daily allowance KW - transport KW - transzport KW - vitamin C SP - 1651 EP - 6 JF - Orvosi hetilap JO - Orv Hetil VL - 154 IS - 42 N2 - Vitamin C requirement is satisfied by natural sources and vitamin C supplements in the ordinary human diet. The two major forms of vitamin C in the diet are L-ascorbic acid and L-dehydroascorbic acid. Both ascorbate and dehydroascorbate are absorbed along the entire length of the human intestine. The reduced form, L-ascorbic acid is imported by an active mechanism, requiring two sodium-dependent vitamin C transporters (SVCT1 and SVCT2). The transport of the oxidized form, dehydroascorbate is mediated by glucose transporters GLUT1, GLUT3 and possibly GLUT4. Initial rate of uptake of both ascorbate and dehydroascorbate is saturable with increasing external substrate concentration. Vitamin C plasma concentrations are tightly controlled when the vitamin is taken orally. It has two simple reasons, on the one hand, the capacity of the transporters is limited, on the other hand the two Na+-dependent transporters can be down-regulated by an elevated level of ascorbate. SN - 0030-6002 UR - https://www.unboundmedicine.com/medline/citation/24121217/[Cellular_and_intracellular_transport_of_vitamin_C__The_physiologic_aspects]_ L2 - https://akjournals.com/doi/10.1556/OH.2013.29712 DB - PRIME DP - Unbound Medicine ER -