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Dendritic cells in IBD pathogenesis: an area of therapeutic opportunity?
J Pathol. 2014 Jan; 232(2):112-20.JP

Abstract

Dysfunction of the mucosal immune system plays an important role in inflammatory bowel disease (IBD) pathogenesis. Dendritic cells are emerging as central players based on both our increasing understanding of how genetic susceptibility impacts the mucosal immune system and the key role of dendritic cells in regulating response to gut microflora. We discuss areas of therapeutic opportunity in this evolving landscape.

Authors+Show Affiliations

Genentech, Inc, South San Francisco, CA, 94080, USA.No affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

24122796

Citation

Bates, Jennifer, and Lauri Diehl. "Dendritic Cells in IBD Pathogenesis: an Area of Therapeutic Opportunity?" The Journal of Pathology, vol. 232, no. 2, 2014, pp. 112-20.
Bates J, Diehl L. Dendritic cells in IBD pathogenesis: an area of therapeutic opportunity? J Pathol. 2014;232(2):112-20.
Bates, J., & Diehl, L. (2014). Dendritic cells in IBD pathogenesis: an area of therapeutic opportunity? The Journal of Pathology, 232(2), 112-20. https://doi.org/10.1002/path.4277
Bates J, Diehl L. Dendritic Cells in IBD Pathogenesis: an Area of Therapeutic Opportunity. J Pathol. 2014;232(2):112-20. PubMed PMID: 24122796.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Dendritic cells in IBD pathogenesis: an area of therapeutic opportunity? AU - Bates,Jennifer, AU - Diehl,Lauri, PY - 2013/09/03/received PY - 2013/09/03/revised PY - 2013/09/22/accepted PY - 2013/10/15/entrez PY - 2013/10/15/pubmed PY - 2014/2/8/medline KW - Crohn's disease KW - colitis KW - dendritic cell KW - inflammation KW - inflammatory bowel disease KW - mucosal immunity SP - 112 EP - 20 JF - The Journal of pathology JO - J. Pathol. VL - 232 IS - 2 N2 - Dysfunction of the mucosal immune system plays an important role in inflammatory bowel disease (IBD) pathogenesis. Dendritic cells are emerging as central players based on both our increasing understanding of how genetic susceptibility impacts the mucosal immune system and the key role of dendritic cells in regulating response to gut microflora. We discuss areas of therapeutic opportunity in this evolving landscape. SN - 1096-9896 UR - https://www.unboundmedicine.com/medline/citation/24122796/Dendritic_cells_in_IBD_pathogenesis:_an_area_of_therapeutic_opportunity L2 - https://doi.org/10.1002/path.4277 DB - PRIME DP - Unbound Medicine ER -