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Prevalence of H. pylori infection and atrophic gastritis among symptomatic and dyspeptic adults in Kazakhstan. A hospital-based screening study using a panel of serum biomarkers.
Anticancer Res. 2013 Oct; 33(10):4595-602.AR

Abstract

BACKGROUND

Health authorities of Kazakhstan are seeking for effective measures to interrupt the untoward trend, projected to increase the current number of gastric cancer (GC) cases (n=3,316) by 50% until the year 2030.

OBJECTIVE

Use of a non-invasive blood test with four stomach-specific biomarkers [Pepsinogen-I (PG-I) and -II (PG-II), amidated gastrin-17 (G-17), and Helicobacter pylori (HP) IgG antibodies], to assess for the prevalence of stomach conditions: Helicobacter pylori (HP) infection and atrophic gastritis (AG), both known to increase GC risk of in Kazakhstan.

MATERIALS AND METHODS

A cohort of 835 (symptomatic and asymptomatic) cases (473 women and 362 men)(median age 46.8 years; range 13.6-74.8) was examined with a panel of biomarkers. Results were assigned in five categories: 1) Healthy stomach, 2) HP infection, 3) atrophic gastritis (AG) of the antrum, 4) AG of the corpus, and 5) AG of both antrum and corpus (pangastritis).

RESULTS

The distribution in these five categories was identical in both sexes (p=0.259). Healthy stomach was detected only in 196 (23.5%) subjects, whereas the vast majority, 62.3% (n=519) had HP infection (with no AG). In 118 (14.1%) subjects, results were consistent with AG; in antrum (n=72), corpus (n=42) or pangastritis (n=4). Prevalence of AG increased with patient's age in both sexes. There was no age-related pattern in biomarker levels, and only slight differences between the genders.

CONCLUSION

While capable of detecting the subjects at risk for GC (HP or AG), GP seems to be a cost-effective means to intervene the current ominous trend in GC incidence in Kazakhstan.

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Publisher Full Text

Authors+Show Affiliations

Benberin V
Department of Gastroenterology, Astana Medical University. 49, Beybitshilik Str., 010000 Astana, Kazakhstan. rbektaeva@bk.ru.
Bektayeva R
No affiliation info available
Karabayeva R
No affiliation info available
Lebedev A
No affiliation info available
Akemeyeva K
No affiliation info available
Paloheimo L
No affiliation info available
Syrjänen K
No affiliation info available

MeSH

AdolescentAdultAgedAntibodies, BacterialBiomarkersDyspepsiaFemaleGastrinsGastritis, AtrophicHelicobacter InfectionsHelicobacter pyloriHumansKazakhstanMaleMiddle AgedPepsinogen APepsinogen CPhenotypePrevalenceSex DistributionYoung Adult

Pub Type(s)

Journal Article

Language

eng

PubMed ID

24123036

Citation

Benberin, Valery, et al. "Prevalence of H. Pylori Infection and Atrophic Gastritis Among Symptomatic and Dyspeptic Adults in Kazakhstan. a Hospital-based Screening Study Using a Panel of Serum Biomarkers." Anticancer Research, vol. 33, no. 10, 2013, pp. 4595-602.
Benberin V, Bektayeva R, Karabayeva R, et al. Prevalence of H. pylori infection and atrophic gastritis among symptomatic and dyspeptic adults in Kazakhstan. A hospital-based screening study using a panel of serum biomarkers. Anticancer Res. 2013;33(10):4595-602.
Benberin, V., Bektayeva, R., Karabayeva, R., Lebedev, A., Akemeyeva, K., Paloheimo, L., & Syrjänen, K. (2013). Prevalence of H. pylori infection and atrophic gastritis among symptomatic and dyspeptic adults in Kazakhstan. A hospital-based screening study using a panel of serum biomarkers. Anticancer Research, 33(10), 4595-602.
Benberin V, et al. Prevalence of H. Pylori Infection and Atrophic Gastritis Among Symptomatic and Dyspeptic Adults in Kazakhstan. a Hospital-based Screening Study Using a Panel of Serum Biomarkers. Anticancer Res. 2013;33(10):4595-602. PubMed PMID: 24123036.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Prevalence of H. pylori infection and atrophic gastritis among symptomatic and dyspeptic adults in Kazakhstan. A hospital-based screening study using a panel of serum biomarkers. AU - Benberin,Valery, AU - Bektayeva,Roza, AU - Karabayeva,Raushan, AU - Lebedev,Aleksandr, AU - Akemeyeva,Kenzhekhan, AU - Paloheimo,Lea, AU - Syrjänen,Kari, PY - 2013/10/15/entrez PY - 2013/10/15/pubmed PY - 2013/12/16/medline KW - Gastric cancer KW - Helicobacter pylori KW - achlorhydria KW - antrum KW - atrophic gastritis KW - biomarker panel KW - blood test KW - corpus KW - gastrin-17 KW - pepsinogens KW - risk factors SP - 4595 EP - 602 JF - Anticancer research JO - Anticancer Res VL - 33 IS - 10 N2 - BACKGROUND: Health authorities of Kazakhstan are seeking for effective measures to interrupt the untoward trend, projected to increase the current number of gastric cancer (GC) cases (n=3,316) by 50% until the year 2030. OBJECTIVE: Use of a non-invasive blood test with four stomach-specific biomarkers [Pepsinogen-I (PG-I) and -II (PG-II), amidated gastrin-17 (G-17), and Helicobacter pylori (HP) IgG antibodies], to assess for the prevalence of stomach conditions: Helicobacter pylori (HP) infection and atrophic gastritis (AG), both known to increase GC risk of in Kazakhstan. MATERIALS AND METHODS: A cohort of 835 (symptomatic and asymptomatic) cases (473 women and 362 men)(median age 46.8 years; range 13.6-74.8) was examined with a panel of biomarkers. Results were assigned in five categories: 1) Healthy stomach, 2) HP infection, 3) atrophic gastritis (AG) of the antrum, 4) AG of the corpus, and 5) AG of both antrum and corpus (pangastritis). RESULTS: The distribution in these five categories was identical in both sexes (p=0.259). Healthy stomach was detected only in 196 (23.5%) subjects, whereas the vast majority, 62.3% (n=519) had HP infection (with no AG). In 118 (14.1%) subjects, results were consistent with AG; in antrum (n=72), corpus (n=42) or pangastritis (n=4). Prevalence of AG increased with patient's age in both sexes. There was no age-related pattern in biomarker levels, and only slight differences between the genders. CONCLUSION: While capable of detecting the subjects at risk for GC (HP or AG), GP seems to be a cost-effective means to intervene the current ominous trend in GC incidence in Kazakhstan. SN - 1791-7530 UR - https://www.unboundmedicine.com/medline/citation/24123036/Prevalence_of_H__pylori_infection_and_atrophic_gastritis_among_symptomatic_and_dyspeptic_adults_in_Kazakhstan__A_hospital_based_screening_study_using_a_panel_of_serum_biomarkers_ L2 - http://ar.iiarjournals.org/cgi/pmidlookup?view=long&pmid=24123036 DB - PRIME DP - Unbound Medicine ER -