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Functional connectivity changes differ in early and late-onset Alzheimer's disease.
Hum Brain Mapp 2014; 35(7):2978-94HB

Abstract

At a similar stage, patients with early onset Alzheimer's disease (EOAD) have greater neocortical but less medial temporal lobe dysfunction and atrophy than the late-onset form of the disease (LOAD). Whether the organization of neural networks also differs has never been investigated. This study aims at characterizing basal functional connectivity (FC) patterns of EOAD and LOAD in two groups of 14 patients matched for disease duration and severity, relative to age-matched controls. All subjects underwent an extensive neuropsychological assessment. Magnetic resonance imaging was used to quantify atrophy and resting-state FC focusing on : the default mode network (DMN), found impaired in earlier studies on AD, and the anterior temporal network (ATN) and dorso-lateral prefrontal network (DLPFN), respectively involved in declarative memory and executive functions. Patterns of atrophy and cognitive impairment in EOAD and LOAD were in accordance with previous reports. FC within the DMN was similarly decreased in both EOAD and LOAD relative to controls. However, a double-dissociated pattern of FC changes in ATN and DLPFN was found. EOAD exhibited decreased FC in the DLPFN and increased FC in the ATN relative to controls, while the reverse pattern was found in LOAD. In addition, ATN and DLPFN connectivity correlated respectively with memory and executive performances, suggesting that increased FC is here likely to reflect compensatory mechanisms. Thus, large-scale neural network changes in EOAD and LOAD endorse both common features and differences, probably related to a distinct distribution of pathological changes.

Authors+Show Affiliations

Aix-Marseille Université, CNRS, CRMBM UMR 7339, 13385, Marseille, France; Aix-Marseille Université, INSERM, Institut des Neurosciences des Systèmes (INS) UMR 1106, 13385, Marseille, France; APHM, Hôpitaux de la Timone, Service de Neurologie et Neuropsychologie, 13385, Marseille, France; APHM, Hôpitaux de la Timone, CEMEREM, 13385, Marseille, France.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

24123475

Citation

Gour, Natalina, et al. "Functional Connectivity Changes Differ in Early and Late-onset Alzheimer's Disease." Human Brain Mapping, vol. 35, no. 7, 2014, pp. 2978-94.
Gour N, Felician O, Didic M, et al. Functional connectivity changes differ in early and late-onset Alzheimer's disease. Hum Brain Mapp. 2014;35(7):2978-94.
Gour, N., Felician, O., Didic, M., Koric, L., Gueriot, C., Chanoine, V., ... Ranjeva, J. P. (2014). Functional connectivity changes differ in early and late-onset Alzheimer's disease. Human Brain Mapping, 35(7), pp. 2978-94. doi:10.1002/hbm.22379.
Gour N, et al. Functional Connectivity Changes Differ in Early and Late-onset Alzheimer's Disease. Hum Brain Mapp. 2014;35(7):2978-94. PubMed PMID: 24123475.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Functional connectivity changes differ in early and late-onset Alzheimer's disease. AU - Gour,Natalina, AU - Felician,Olivier, AU - Didic,Mira, AU - Koric,Lejla, AU - Gueriot,Claude, AU - Chanoine,Valérie, AU - Confort-Gouny,Sylviane, AU - Guye,Maxime, AU - Ceccaldi,Mathieu, AU - Ranjeva,Jean Philippe, Y1 - 2013/10/05/ PY - 2013/02/19/received PY - 2013/06/04/revised PY - 2013/07/11/accepted PY - 2013/10/15/entrez PY - 2013/10/15/pubmed PY - 2015/1/23/medline KW - early onset Alzheimer disease KW - executive function KW - late onset Alzheimer disease KW - magnetic resonance imaging KW - memory KW - neural networks SP - 2978 EP - 94 JF - Human brain mapping JO - Hum Brain Mapp VL - 35 IS - 7 N2 - At a similar stage, patients with early onset Alzheimer's disease (EOAD) have greater neocortical but less medial temporal lobe dysfunction and atrophy than the late-onset form of the disease (LOAD). Whether the organization of neural networks also differs has never been investigated. This study aims at characterizing basal functional connectivity (FC) patterns of EOAD and LOAD in two groups of 14 patients matched for disease duration and severity, relative to age-matched controls. All subjects underwent an extensive neuropsychological assessment. Magnetic resonance imaging was used to quantify atrophy and resting-state FC focusing on : the default mode network (DMN), found impaired in earlier studies on AD, and the anterior temporal network (ATN) and dorso-lateral prefrontal network (DLPFN), respectively involved in declarative memory and executive functions. Patterns of atrophy and cognitive impairment in EOAD and LOAD were in accordance with previous reports. FC within the DMN was similarly decreased in both EOAD and LOAD relative to controls. However, a double-dissociated pattern of FC changes in ATN and DLPFN was found. EOAD exhibited decreased FC in the DLPFN and increased FC in the ATN relative to controls, while the reverse pattern was found in LOAD. In addition, ATN and DLPFN connectivity correlated respectively with memory and executive performances, suggesting that increased FC is here likely to reflect compensatory mechanisms. Thus, large-scale neural network changes in EOAD and LOAD endorse both common features and differences, probably related to a distinct distribution of pathological changes. SN - 1097-0193 UR - https://www.unboundmedicine.com/medline/citation/24123475/Functional_connectivity_changes_differ_in_early_and_late_onset_Alzheimer's_disease_ L2 - https://doi.org/10.1002/hbm.22379 DB - PRIME DP - Unbound Medicine ER -