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Peroral pancreatoscopy using the SpyGlass system for the assessment of intraductal papillary mucinous neoplasm of the pancreas.
J Hepatobiliary Pancreat Sci. 2014 Jun; 21(6):410-7.JH

Abstract

BACKGROUND

Peroral pancreatoscopy (POPS) using a mother-baby endoscope system is often useful for assessment of intraductal papillary mucinous neoplasm (IPMN) of the pancreas with main pancreatic duct (MPD) involvement, but is not widely used for several reasons. The aim of this study was to evaluate the usefulness of the SpyGlass Direct Visualization System for assessment of IPMN.

METHODS

Seventeen patients diagnosed with possible IPMN with MPD dilation underwent peroral pancreatoscopy using the SpyGlass system at our institution. The quality of visualization and the sensitivities of cytological and pathological investigations for diagnosing malignant lesions were evaluated.

RESULTS

Peroral pancreatoscopy was performed using the SpyScope in 12 patients and an endoscopic retrograde cholangiopancreatography (ERCP) catheter in five patients. Sufficient visualization was achieved in 92% of cases using the SpyScope and 40% of cases using the ERCP catheter. Biopsy under direct visualization was successful in seven patients. Biopsy specimens showed adenocarcinoma in one patient, benign neoplastic epithelium in five patients, and regenerative changes in one patient; and had 25% sensitivity and 100% specificity for detecting malignancy. SpyGlass pancreatoscopy with irrigation cytology had 100% sensitivity and 100% specificity for detecting malignancy. SpyGlass pancreatoscopy was useful for determining the operative excision line in three patients. There were no severe procedure-related adverse events.

CONCLUSIONS

Peroral pancreatoscopy using the SpyGlass system seems to be feasible and useful for assessment of IPMN with a dilated MPD.

Authors+Show Affiliations

Department of Surgery and Oncology, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka, 812-8582, Japan.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

24123930

Citation

Nagayoshi, Yosuke, et al. "Peroral Pancreatoscopy Using the SpyGlass System for the Assessment of Intraductal Papillary Mucinous Neoplasm of the Pancreas." Journal of Hepato-biliary-pancreatic Sciences, vol. 21, no. 6, 2014, pp. 410-7.
Nagayoshi Y, Aso T, Ohtsuka T, et al. Peroral pancreatoscopy using the SpyGlass system for the assessment of intraductal papillary mucinous neoplasm of the pancreas. J Hepatobiliary Pancreat Sci. 2014;21(6):410-7.
Nagayoshi, Y., Aso, T., Ohtsuka, T., Kono, H., Ideno, N., Igarashi, H., Takahata, S., Oda, Y., Ito, T., & Tanaka, M. (2014). Peroral pancreatoscopy using the SpyGlass system for the assessment of intraductal papillary mucinous neoplasm of the pancreas. Journal of Hepato-biliary-pancreatic Sciences, 21(6), 410-7. https://doi.org/10.1002/jhbp.44
Nagayoshi Y, et al. Peroral Pancreatoscopy Using the SpyGlass System for the Assessment of Intraductal Papillary Mucinous Neoplasm of the Pancreas. J Hepatobiliary Pancreat Sci. 2014;21(6):410-7. PubMed PMID: 24123930.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Peroral pancreatoscopy using the SpyGlass system for the assessment of intraductal papillary mucinous neoplasm of the pancreas. AU - Nagayoshi,Yosuke, AU - Aso,Teppei, AU - Ohtsuka,Takao, AU - Kono,Hiroshi, AU - Ideno,Noboru, AU - Igarashi,Hisato, AU - Takahata,Shunichi, AU - Oda,Yoshinao, AU - Ito,Tetsuhide, AU - Tanaka,Masao, Y1 - 2013/10/14/ PY - 2013/10/15/entrez PY - 2013/10/15/pubmed PY - 2015/6/17/medline KW - Intraductal papillary mucinous neoplasm KW - Pancreatoscopy KW - SpyGlass SP - 410 EP - 7 JF - Journal of hepato-biliary-pancreatic sciences JO - J Hepatobiliary Pancreat Sci VL - 21 IS - 6 N2 - BACKGROUND: Peroral pancreatoscopy (POPS) using a mother-baby endoscope system is often useful for assessment of intraductal papillary mucinous neoplasm (IPMN) of the pancreas with main pancreatic duct (MPD) involvement, but is not widely used for several reasons. The aim of this study was to evaluate the usefulness of the SpyGlass Direct Visualization System for assessment of IPMN. METHODS: Seventeen patients diagnosed with possible IPMN with MPD dilation underwent peroral pancreatoscopy using the SpyGlass system at our institution. The quality of visualization and the sensitivities of cytological and pathological investigations for diagnosing malignant lesions were evaluated. RESULTS: Peroral pancreatoscopy was performed using the SpyScope in 12 patients and an endoscopic retrograde cholangiopancreatography (ERCP) catheter in five patients. Sufficient visualization was achieved in 92% of cases using the SpyScope and 40% of cases using the ERCP catheter. Biopsy under direct visualization was successful in seven patients. Biopsy specimens showed adenocarcinoma in one patient, benign neoplastic epithelium in five patients, and regenerative changes in one patient; and had 25% sensitivity and 100% specificity for detecting malignancy. SpyGlass pancreatoscopy with irrigation cytology had 100% sensitivity and 100% specificity for detecting malignancy. SpyGlass pancreatoscopy was useful for determining the operative excision line in three patients. There were no severe procedure-related adverse events. CONCLUSIONS: Peroral pancreatoscopy using the SpyGlass system seems to be feasible and useful for assessment of IPMN with a dilated MPD. SN - 1868-6982 UR - https://www.unboundmedicine.com/medline/citation/24123930/Peroral_pancreatoscopy_using_the_SpyGlass_system_for_the_assessment_of_intraductal_papillary_mucinous_neoplasm_of_the_pancreas_ L2 - https://doi.org/10.1002/jhbp.44 DB - PRIME DP - Unbound Medicine ER -